Results 71 to 80 of about 320,134 (341)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

On higher spins and the tensionless limit of String Theory [PDF]

, 2003
We discuss string spectra in the low-tension limit using the BRST formalism, with emphasis on the role of triplets of totally symmetric tensors and spinor-tensors and their generalizations to cases with mixed symmetry and to (A)dS backgrounds.
A. Sagnotti, Angelantonj, Angelantonj, Angelantonj, Aragone, Banks, Batalin, Becchi, Becchi, Bekaert, Bengtsson, Bianchi, Bianchi, Blumenhagen, Bonelli, Bonelli, Buchbinder, Buchbinder, Buchbinder, Buchbinder, Buchbinder, Buchbinder, Burdik, Burdik, Damour, de Medeiros, de Wit, Deser, Deser, Deser, Deser, Deser, Dixon, Engquist, Engquist, Fang, Fang, Fradkin, Fradkin, Fradkin, Fradkin, Fradkin, Fradkin, Francia, Francia, Freedman, Fronsdal, Fronsdal, Girardello, Gubser, Gustafsson, Henneaux, Henneaux, Isberg, Karlhede, Kato, Kazama, Klebanov, Leigh, Leigh, Lindstrom, Lopatin, M. Tsulaia, Maldacena, Marcus, Metsaev, Neveu, Neveu, Ohta, Ohta, Pashnev, Pashnev, Sagnotti, Sagnotti, Schild, Schnitzer, Seiberg, Sezgin, Sezgin, Sezgin, Sezgin, Sezgin, Sezgin, Sezgin, Siegel, Siegel, Sundborg, Taylor, Thierry-Mieg, Vasiliev, Vasiliev, Vasiliev, Vasiliev, Vasiliev, Vasiliev, Vasiliev, Vasiliev, Witten, Witten, Zinoviev   +99 more
core   +2 more sources

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Natural R-Parity, \mu-term, and Fermion Mass Hierarchy From Discrete Gauge Symmetries [PDF]

, 2002
In the minimal supersymmetric Standard Model with seesaw neutrino masses we show how R-parity can emerge naturally as a discrete gauge symmetry. The same discrete symmetry explains the smallness of the \mu-term (the Higgsino mass parameter) via the ...
Abbot, Atick, Babu, Babu, Bajc, Banks, Berezhiani, Berezhiani, Binetruy, Binetruy, Binetruy, Chkareuli, Choi, Choudhuri, Chun, Coleman, Dienes, Dienes, Dienes, Dine, Dvali, Dvali, Feng, Font, Froggatt, Gell-Mann, Giddings, Giddings, Ginsparg, Gogoladze, Gomez, Green, Green, Green, Guidice, Hawking, Ibanez, Ibanez, Ibanez, Ibanez, Ibanez, Ibanez, Ilia Gogoladze, Joshipura, K.S. Babu, Kai Wang, Kakushadze, Kallosh, Krauss, Kurosawa, Lavrelashvili, Lopez, Ma, Ma, Maekawa, Maekawa, Martin, Mohapatra, Mohapatra, Mohapatra, Nir, Ohlsson, Preskill, Ramond, Shafi, Shafi, Shafi   +66 more
core   +2 more sources

(NON-)ALIGNED GAUGES AND GLOBAL GAUGE SYMMETRY BREAKING [PDF]

Modern Physics Letters A, 2012
The concept of (global) gauge symmetry breaking plays an important role in many areas of physics. Since the corresponding symmetry is a gauge symmetry, its breaking is actually gauge-dependent. Thus, it is possible to design gauges which restore the symmetry as good as possible.
openaire   +2 more sources

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

Gauge invariance and holographic renormalization

Physics Letters B, 2015
We study the gauge invariance of physical observables in holographic theories under the local diffeomorphism. We find that gauge invariance is intimately related to the holographic renormalization: the local counter terms defined in the boundary cancel ...
Keun-Young Kim, Kyung Kiu Kim, Yunseok Seo, Sang-Jin Sin   +3 more
doaj   +1 more source

Vector dark matter from a gauged SU(2) symmetry

Journal of High Energy Physics, 2021
We propose a scenario of dark sector described by a hidden SU(2) gauge symmetry which is broken by a vacuum expectation value(VEV) of a scalar multiplet.
Takaaki Nomura, Hiroshi Okada, Seokhoon Yun   +2 more
doaj   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Residual gauge symmetry and color confinement in the Yang–Mills theory

Nuclear Physics B
We examine the restoration of the residual gauge symmetry in the Yang–Mills theory to be regarded as a confinement criterion. For this purpose, we restrict the four-dimensional SU(2) Yang–Mills instantons to those with spatial spherical symmetry SO(3 ...
Naoki Fukushima, Kei-Ichi Kondo
doaj   +1 more source