Results 61 to 70 of about 27,932 (316)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Non-invertible global symmetries and completeness of the spectrum

open access: yesJournal of High Energy Physics, 2021
It is widely believed that consistent theories of quantum gravity satisfy two basic kinematic constraints: they are free from any global symmetry, and they contain a complete spectrum of gauge charges.
Ben Heidenreich   +5 more
doaj   +1 more source

Holism and Structuralism in U(1) Gauge Theory [PDF]

open access: yes, 2004
After decades of neglect philosophers of physics have discovered gauge theories--arguably the paradigm of modern field physics--as a genuine topic for foundational and philosophical research.
Lyre, Holger
core  

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

open access: yesFEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Automatic Peccei–Quinn symmetry

open access: yesEuropean Physical Journal C: Particles and Fields, 2019
We present a dynamical (composite) axion model where the Peccei–Quinn (PQ) symmetry arises automatically as a consequence of chirality and gauge symmetry. The Standard Model is simply extended by a confining and chiral SU(5) gauge symmetry.
M. B. Gavela   +3 more
doaj   +1 more source

Scattering Amplitudes of Massive N=2 Gauge Theories in Three Dimensions [PDF]

open access: yes, 2013
We study the scattering amplitudes of mass-deformed Chern-Simons theories and Yang-Mills-Chern-Simons theories with N=2 supersymmetry in three dimensions. In particular, we derive the on-shell supersymmetry algebras which underlie the scattering matrices
Agarwal, Abhishek   +6 more
core   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

open access: yesFEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill   +4 more
wiley   +1 more source

Emergent gauge symmetries: making symmetry as well as breaking it [PDF]

open access: yesPhilosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences, 2021
Gauge symmetries play an essential role in determining the interactions of particle physics. Where do they come from? Might the gauge symmetries of the Standard Model unify in the ultraviolet or might they be emergent in the infrared, below some large scale close to the Planck scale?
openaire   +3 more sources

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

open access: yesFEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose   +9 more
wiley   +1 more source

Gauge Theories and Holisms [PDF]

open access: yes, 2004
Those looking for holism in contemporary physics have focused their attention primarily on quantum entanglement. But some gauge theories arguably also manifest the related phenomenon of nonseparability.
Healey, Richard
core  

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