Results 111 to 120 of about 772,485 (319)

Inhibition of acyl‐CoA synthetase long‐chain isozymes decreases multiple myeloma cell proliferation and causes mitochondrial dysfunction

Molecular Oncology, EarlyView.
Triacsin C inhibition of the acyl‐CoA synthetase long chain (ACSL) family decreases multiple myeloma cell survival, proliferation, mitochondrial respiration, and membrane potential. Made with Biorender.com. Multiple myeloma (MM) is an incurable cancer of plasma cells with a 5‐year survival rate of 59%.
Connor S. Murphy, Heather Fairfield, Victoria E. DeMambro, Samaa Fadel, Carlos A. Gartner, Michelle Karam, Christian Potts, Princess Rodriguez, Ya‐Wei Qiang, Habib Hamidi, Xiangnan Guan, Calvin P. H. Vary, Michaela R. Reagan   +12 more
wiley   +1 more source

Cold atoms meet lattice gauge theory. [PDF]

Philos Trans A Math Phys Eng Sci, 2022
Aidelsburger M, Barbiero L, Bermudez A, Chanda T, Dauphin A, González-Cuadra D, Grzybowski PR, Hands S, Jendrzejewski F, Jünemann J, Juzeliūnas G, Kasper V, Piga A, Ran SJ, Rizzi M, Sierra G, Tagliacozzo L, Tirrito E, Zache TV, Zakrzewski J, Zohar E, Lewenstein M.   +21 more
europepmc   +1 more source

Cystatin A promotes the antitumor activity of T helper type 1 cells and dendritic cells in murine models of pancreatic cancer

Molecular Oncology, EarlyView.
Pancreatic ductal adenocarcinoma (PDAC) is a disease with very poor prognosis due to therapeutic limitations. We investigated the antitumor effects of cystatin A (CSTA) in PDAC murine models. We are first to confirm that CSTA enhances T helper type 1‐mediated antitumor effects through promotion of dendritic cells and M1 macrophage activity. CSTA can be
Alessandro Nasti, Shingo Inagaki, Tuyen Thuy Bich Ho, Akihiro Seki, Keiko Yoshida, Kosuke Satomura, Yoshio Sakai, Shuichi Kaneko, Taro Yamashita   +8 more
wiley   +1 more source

Freezing and BPS jumping

Journal of High Energy Physics
We report a novel BPS jumping phenomenon of 5d N $$ \mathcal{N} $$ = 1 supersymmetric gauge theories whose brane configuration is equipped with an O7-plane.
Sung-Soo Kim, Xiaobin Li, Satoshi Nawata, Futoshi Yagi   +3 more
doaj   +1 more source

Peripheral blood leukocyte signatures as biomarkers in relapsed ovarian cancer patients receiving combined anti‐CD73/anti‐PD‐L1 immunotherapy in arm A of the NSGO‐OV‐UMB1/ENGOT‐OV30 trial

Molecular Oncology, EarlyView.
Using mass cytometry, we analyzed serial blood samples from patients with relapsed epithelial ovarian cancer (EOC) treated with oleclumab–durvalumab combination immunotherapy in the NSGO‐OV‐UMB1/ENGOT‐OV30 trial. Our analysis identified potential predictive, monitoring, and response biomarkers detectable through liquid biopsy. These findings facilitate
Luka Tandaric, Annika Auranen, Katrin Kleinmanns, René DePont Christensen, Liv Cecilie Vestrheim Thomsen, Cara Ellen Wogsland, Emmet McCormack, Johanna Mäenpää, Kristine Madsen, Karen Stampe Petersson, Mansoor Raza Mirza, Line Bjørge   +11 more
wiley   +1 more source

Molecular and functional profiling unravels targetable vulnerabilities in colorectal cancer

Molecular Oncology, EarlyView.
We used whole exome and RNA‐sequencing to profile divergent genomic and transcriptomic landscapes of microsatellite stable (MSS) and microsatellite instable (MSI) colorectal cancer. Alterations were classified using a computational score for integrative cancer variant annotation and prioritization.
Efstathios‐Iason Vlachavas, Konstantinos Voutetakis, Vivian Kosmidou, Spyridon Tsikalakis, Spyridon Roditis, Konstantinos Pateas, Ryangguk Kim, Kymberleigh Pagel, Stephan Wolf, Gregor Warsow, Antonia Dimitrakopoulou‐Strauss, Georgios N. Zografos, Alexander Pintzas, Johannes Betge, Olga Papadodima, Stefan Wiemann   +15 more
wiley   +1 more source

Unification of Non-Abelian SU(N) Gauge Theory and Gravitational Gauge Theory [PDF]

Commun.Theor.Phys.38:455-460,2002, 2003
In this paper, a general theory on unification of non-Abelian SU(N) gauge interactions and gravitational gauge interactions is discussed. SU(N) gauge interactions and gravitational gauge interactions are formulated on the similar basis and are unified in a semi-direct product group GSU(N).
arxiv  

Targeting PRAME directly or via EZH2 inhibition overcomes retinoid resistance and represents a novel therapy for keratinocyte carcinoma

Molecular Oncology, EarlyView.
The study evaluated the function and therapeutic implications of PRAME in basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). The findings demonstrate that PRAME impairs keratinocyte differentiation pathways. Furthermore, PRAME impairs anticancer response to retinoid compounds in BCC and SCC cells.
Brandon Ramchatesingh, Amelia Martinez Villarreal, Philippe Lefrançois, Jennifer Gantchev, Sriraam Sivachandran, Samy Abou Setah, Ivan V. Litvinov   +6 more
wiley   +1 more source

Topology of 3-dimensional manifolds [PDF]

ریاضی و جامعه
This is the second paper from a trio which reviews some of the progress in low dimensional topology in the past century. Starting with the work of Poincare in the last years of 19th century and first few years of 20th century, we review the major steps ...
Eaman Eftekhary
doaj   +1 more source

The problem of gauge invariance in Dirac field theory [PDF]

arXiv, 2003
Quantum field theory is assumed to be gauge invariant. However it is well known that when certain quantities are calculated using perturbation theory the results are not gauge invariant. The non-gauge invariant terms have to be removed in order to obtain a physically correct result.
arxiv