Results 111 to 120 of about 798,500 (344)

Charges in Gauge Theories [PDF]

Symmetry, Integrability and Geometry: Methods and Applications, 2007
Recent progress in the construction of both electric, coloured and magnetic charges in gauge theories will be presented. The topological properties of the charged sectors will be highlighted as well as the applications of this work to confinement and infrared dynamics.
openaire   +4 more sources

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Topology of 3-dimensional manifolds [PDF]

ریاضی و جامعه
This is the second paper from a trio which reviews some of the progress in low dimensional topology in the past century. Starting with the work of Poincare in the last years of 19th century and first few years of 20th century, we review the major steps ...
Eaman Eftekhary
doaj   +1 more source

Inflation and Gauge Mediation in Supersymmetric Gauge Theory

, 2011
We propose a simple high-scale inflationary scenario based on a phenomenologically viable model with direct gauge mediation of low-scale supersymmetry breaking. Hybrid inflation is occurred in a hidden supersymmetry breaking sector. Two hierarchical mass
Nakai, Yuichiro, Sakai, Manabu
core   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Chiral gauge theory and gravity from unconventional supersymmetry

Journal of High Energy Physics, 2020
From a gauge SU (2, 2|2) model with broken supersymmetry, we construct an action for SU(2)×U (1) Yang-Mills theory coupled to gravity and matter in four dimensions. The connection components for AdS boosts and special conformal translations are auxiliary
Pedro D. Alvarez, Mauricio Valenzuela, Jorge Zanelli   +2 more
doaj   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

Fluid/p-form duality

Physics Letters B
In this study, we demonstrate that an inviscid fluid in a near-equilibrium state, when viewed in the Lagrangian picture in d+1 spacetime dimensions, can be reformulated as a (d−1)-form gauge theory.
V. Taghiloo, M.H. Vahidinia
doaj   +1 more source