Results 51 to 60 of about 247,705 (346)
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
Dignity and Social Meaning: \u3ci\u3eObergefell\u3c/i\u3e, \u3ci\u3eWindsor\u3c/i\u3e, and \u3ci\u3eLawrence\u3c/i\u3e as Constitutional Dialogue [PDF]
, 2019 The U.S. Supreme Court’s three most important gay and lesbian rights decisions—Obergefell v. Hodges, United States v. Windsor, and Lawrence v. Texas—are united by the principle that gays and lesbians are entitled to dignity.
Sanders, Steve
core +1 more source
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
In/Visibility of LGBTQ People in the Arab Spring: Making LGBTQ Voices Heard [PDF]
, 2012 LGBTQ use of the internet is a growing area of study. However most studies focus mainly on the US and the UK, and none pays much (if any) attention to the experience of LGBTQ people in countries where it is illegal to be LGBTQ.
Kreps, David
core
The Role Of Doctors And Nurses In Hiv/Aids Handling Efforts Of The Gays
Soepra: Jurnal Hukum Kesehatan, 2018 Health was one of the important and main elements in improving community’s welfare. Doctors and nurses were part of health workers providing health services to the community to improve their health status, including in HIV/AIDS handling efforts.
Ludgardis Ramni +2 more
doaj +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Saúde e Sociedade, 2015 Pretendeu-se com a pesquisa realizada estudar e comparar padrões de testagem em relação ao VIH; resultados do teste para o VIH; e comportamentos sexuais preventivos de homens homo, hetero e bissexuais. Os dados foram recolhidos através de um questionário
Nuno Nodin +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad +12 more
wiley +1 more source
, 2019 Existing research suggests that supporters of gay rights have outmobilized their opponents, leading to policy changes in advanced industrialized democracies.
Ayoub, Phillip M., Page, Douglas D.
core +2 more sources
VIOLÊNCIA NA INTIMIDADE NOS RELACIONAMENTOS HOMOSSEXUAIS GAYS E LÉSBICOS
Psicologia & SociedadeResumo O presente estudo teve como objetivo estudar a prevalência da violência na intimidade nos relacionamentos homossexuais, gays e lésbicos. A amostra foi constituída por 48 participantes de nacionalidade portuguesa, com idades compreendidas entre os ...
Lúcia Osório +2 more
doaj +1 more source