Results 171 to 180 of about 31,524 (206)

Total synthesis of globotriaosylceramide (Gb3) and lysoglobotriaosylceramide (lysoGb3)

Carbohydrate Research, 1990
We have recently reported a highly efficient and stereocontrolled synthesis of globotriaosylceramide (Gb3, 1) in optically pure form. Key to our synthetic strategy was the implementation of the two-stage activation of thioglycosides for formation of the glycosidic bonds and the utilization of (2S, 3S, 4E)-2-azido-3-O-(tert-butyldimethylsilyl)-4 ...
K C, Nicolaou, T J, Caulfield, H, Katoaka   +2 more
openaire   +2 more sources

Discovery and design of an aptamer that inhibits Shiga toxin type 2 activity by blocking Stx2 B subunit-Gb3 interaction.

International Journal of Biological Macromolecules
Shiga toxin (Stx) is the definitive virulence factor of Stx-producing Escherichia coli. This bacterial pathogen can contaminate food and threaten human health.
Mengxia Duan, Kexin Ren, Xiaowan Chen, Yuting Chang, Ziyu Lv, Zhouping Wang, Shijia Wu, Nuo Duan   +7 more
semanticscholar   +1 more source

Globotriaosylsphingosine (lyso-Gb3) and analogues in plasma and urine of patients with Fabry disease and correlations with long-term treatment and genotypes in a nationwide female Danish cohort

Journal of Medical Genetics, 2020
Introduction Recent studies showed the usefulness of globotriaosylsphingosine (lyso-Gb3) and related analogues, deacylated forms of globotriaosylceramide (Gb3), for high-risk screening, treatment monitoring and follow-up for patients with Fabry disease ...
G. Effraimidis, U. Feldt-Rasmussen, Å. Rasmussen, P. Lavoie, Mona Abaoui, Michel Boutin, C. Auray-Blais   +6 more
semanticscholar   +1 more source

MPEC 2023-H48 : 2023 GB3

2023
The Minor Planet Electronic Circulars contain information on unusual minor planets, routine data on comets and natural satellites, and occasional editorial announcements. They are published on behalf of Division F of the International Astronomical Union by the Minor Planet Center, Smithsonian Astrophysical Observatory, Cambridge, MA 02138, U.S.A.
openaire   +1 more source

Lose the lipid: renoprotection conferred by Gb3 synthase knockout

Kidney International, 2019
The ability of proximal tubule cells to internalize filtered proteins over a broad concentration range is essential for maintaining a protein-free urine but also renders these cells uniquely susceptible to cytotoxic damage. Morace et al. find that knockout of globotriaosylceramide synthase, an enzyme required for production of Gb3 and other members of ...
Anatália, Labilloy, Ora A, Weisz
openaire   +2 more sources

Falsely elevated urinary Gb3 (globotriaosylceramide, CTH, GL3)

Molecular Genetics and Metabolism, 2009
and C17-Gb3 as internal standards. Ten microliters are injected into a UPLC-MS/MS for the simultaneous determination of creatinine and Gb3. Urine of 100 healthy subjects from newborns to 65 years old was analyzed. The concentration of creatinine in urine varied widely due to diet or age: from less then 1 lmol/mL in infants and some adults to higher ...
Sabrina, Forni, Xiaowei, Fu, Raphael, Schiffmann, Lawrence, Sweetman   +3 more
openaire   +2 more sources

Kalinin, epiligrin and GB3 antigen: kalinepiligrinin-3?

Current Biology, 1992
Basement membranes are specialized sheets of extracelMar matrix that underlie the epithelia and endothelia and surround muscle and nerve cells. The adhesion of epithelial cells to basement membranes involves specialized junctions known as hemidesmosomes, which are not found in other tissues.
F M, Watt, N A, Hotchin
openaire   +2 more sources

Increased prevalence of CMV gB3 in marrow of patients with aplastic anemia

Blood, 2001
Various infectious agents have been implicated in causing aplastic anemia (AA), either by direct lytic infection or by inducing a pathophysiologic host immune response.[1][1] But little attention has been given to cytomegalovirus (CMV), even though the myelosuppressive potential of this virus ...
B, Torok-Storb, L, Bolles, M, Iwata, K, Doney, G E, Sale, T A, Gooley, R, Storb   +6 more
openaire   +2 more sources

Summary of the parallel session GB3

The Sixteenth Marcel Grossmann Meeting, 2023
G. V. Vereshchagin, D. Bégué
openaire   +1 more source

Novel Mechansims for Pk (Gb3) Inhibition of HIV Infection.

Blood, 2005
Abstract Many blood group antigens belong to a class of lipid-sugar conjugate molecules known as glycosphingolipids (GSLs), including ABH, Lewis and P blood group systems. GSLs are implicated in HIV-host cell fusion, and several bind to HIV-gp120 in vitro.
Donald R. Branch, Vered Yahalom, Cyril Levene, Martin L. Olsson, Jeffrey A. Medin, Clifford A. Lingwood, Nicole Lund   +6 more
openaire   +1 more source