Results 1 to 10 of about 385 (69)

Early life infection and proinflammatory, atherogenic metabolomic and lipidomic profiles in infancy: a population-based cohort study [PDF]

eLife, 2022
Background: The risk of adult onset cardiovascular and metabolic (cardiometabolic) disease accrues from early life. Infection is ubiquitous in infancy and induces inflammation, a key cardiometabolic risk factor, but the relationship between infection ...
Toby Mansell, Richard Saffery, Satvika Burugupalli, Anne-Louise Ponsonby, Mimi LK Tang, Martin O'Hely, Siroon Bekkering, Adam Alexander T Smith, Rebecca Rowland, Sarath Ranganathan, Peter D Sly, Peter Vuillermin, Fiona Collier, Peter Meikle, David Burgner, Barwon Infant Study Investigator Group   +15 more
doaj   +4 more sources

Global Lipidome Profiling Revealed Multifaceted Role of Lipid Species in Hepatitis C Virus Replication, Assembly, and Host Antiviral Response

Viruses, 2023
Hepatitis C virus (HCV) is a major human pathogen that requires a better understanding of its interaction with host cells. There is a close association of HCV life cycle with host lipid metabolism.
Khursheed Ul Islam, Saleem Anwar, Ayyub A. Patel, Mohammed Tarek Mirdad, Mahmoud Tarek Mirdad, Md Iqbal Azmi, Tanveer Ahmad, Zeeshan Fatima, Jawed Iqbal   +8 more
doaj   +2 more sources

Novel Relationship Between Plasmalogen Lipid Signatures and Carnosine in Humans

, 2021
INTRODUCTION: Carnosine is a naturally occurring dipeptide abundant in the skeletal and cardiac muscle and brain, which has been shown to improve glucose metabolism and cardiovascular risk.
Meikle, P, Naderpoor, N, Fernández-Real, JM, Mousa, A, de Courten, B, Mayneris-Perxachs, J   +5 more
core   +2 more sources

Structure of Trihexosylceramide Biosynthesized in Vitro

Journal of Biological Chemistry, 1973
Abstract Trihexosylceramide biosynthesized in vitro from lactosylceramide and UDP-galactose in the presence of a galactosyltransferase from rat spleen microsomes or bone marrow was shown by methylation to have the structure galactopyranosyl-α-(1 → 3)-galactopyranosyl-β-(1 → 4)-glucopyranosyl-β-(1 → 1)-ceramide.
P, Stoffyn, A, Stoffyn, G, Hauser
openaire   +4 more sources

Sulfated Trihexosylceramide from Gastric Mucosa Containing N-Acetylglucosamine [PDF]

European Journal of Biochemistry, 1980
A new sulfated glycosphingolipid containing N-acetylglucosamine has been isolated from hog gastric mucosa by extraction with sodium acetate. Based on the results of partial acid hydrolysis, sequential degradation with specific glycosidases, and methylation analysis of the native and desulfated compound, the structure of this glycolipid is proposed to ...
A, Slomiany, B L, Slomiany, C, Annese
openaire   +2 more sources

Change of isoforms' spectra of α-l-fucosidase from human skin fibroblasts in intracellular storage of nonhydrolyzable substances [PDF]

, 1995
The effect of exogenous and endogenous products storage in lysosomes on the activity and multiple forms of α-l-fucosidase from human skin fibroblasts was investigated.
Artykova, Gulbahar, Beyer, Elena, Ivleva, Tatiana, Wiederschain, German   +3 more
core   +1 more source

Mechanism for the biosynthesis of Forssman glycolipid from trihexosylceramide.

Journal of Biological Chemistry, 1980
The mechanism for the synthesis of Forssman glycolipid (GalNAc-alpha-GalNAc-beta-Gal-Gal-Glc-Cer) from trihexosylceramide (Gal-Gal-Glc-Cer, Hex3Cer) and radioactively labeled UDP-N-acetylgalactosamine catalyzed by particulate beta- and alpha-N-acetylgalactosaminyl-transferase of hamster NIL-2K cells was studied.
S, Kijimoto-Ochiai, N, Yokosawa, A, Makita   +2 more
openaire   +2 more sources

Ceramide metabolism alterations contribute to Tumor Necrosis Factor-induced melanoma dedifferentiation: from basic research to immunotherapy in advanced melanoma patients.

, 2023
International audienceAdvanced cutaneous melanoma is a poor prognosis skin cancer with high metastatic potential. During metastasis, melanoma cells may dedifferentiate towards an invasive phenotype, resulting in decreased expression of MITF-dependent ...
Mucher, Elodie, Meyer, Nicolas, Jung, Benjamin, Genais, Matthieu, Garcia, Virginie, Montfort, Anne, Medin, Jeffrey, A., Tosolini, Marie, Andrieu-Abadie, Nathalie, Clarke, Christopher, J, Pancaldi, Vera, Levade, Thierry, Dufau, Carine, Ségui, Bruno   +13 more
core   +1 more source

Ceramide metabolism alterations contribute to Tumor Necrosis Factor-induced melanoma dedifferentiation.

, 2023
International audienceAdvanced cutaneous melanoma is a poor-prognosis skin cancer with high metastatic potential. During metastatic spreading, melanoma cells can dedifferentiate towards an invasive phenotype, leading to a decreased expression of MITF ...
Mucher, Elodie, Meyer, Nicolas, Jung, Benjamin, Genais, Matthieu, Garcia, Virginie, Montfort, Anne, Medin, Jeffrey, A., Tosolini, Marie, Andrieu-Abadie, Nathalie, Clarke, Christopher, J, Pancaldi, Vera, Levade, Thierry, Dufau, Carine, Ségui, Bruno   +13 more
core   +1 more source

Effects of verocytotoxin-1 on nonadherent human monocytes: Binding characteristics, protein synthesis, and induction of cytokine release

, 1996
The epidemic form of the hemolytic uremic syndrome (HUS) has been associated with a verocytotoxin producing Escherichia coli infection. Endothelial cell damage of glomeruli and arterioles of the kidney plays a central role in the pathogenesis of HUS.
Verstraten, R.G.G., Heuvel, L.P.W.J. van den, Monnens, L.A.H., Hinsbergh, V.W.M. van, Setten, P.A. van   +4 more
core   +1 more source