Results 11 to 20 of about 401 (83)

Elevated lipid class concentrations in females with anorexia nervosa before and after intensive weight restoration treatment—A lipidomics study

International Journal of Eating Disorders, Volume 56, Issue 12, Page 2260-2272, December 2023., 2023
Abstract Objective To study the plasma lipidome of patients with anorexia nervosa (AN) before and after weight restoration treatment and report associations with AN subtypes and oral contraceptive pill (OCP) usage. Methods Quantitative shotgun lipidomics analysis was used to study plasma lipids of 50 female patients with AN before and after weight ...
Alia Arif Hussain, Mesut Bilgin, Jessica Carlsson, Mads Møller Foged, Erik Lykke Mortensen, Cynthia M. Bulik, René Klinkby Støving, Jan Magnus Sjögren   +7 more
wiley   +1 more source

Discovery of lipid profiles in plasma‐derived extracellular vesicles as biomarkers for breast cancer diagnosis

Cancer Science, Volume 114, Issue 10, Page 4020-4031, October 2023., 2023
This study investigated the use of lipid profiles in plasma‐derived extracellular vesicles as non‐invasive biomarkers for diagnosing, staging, and subtyping breast cancer. Lipid profiling effectively discriminated breast cancer progression and subtypes, suggesting its potential as a promising approach to breast cancer management.
Lin Liu, Masahiro Kawashima, Masahiro Sugimoto, Kazuhiro Sonomura, Fengling Pu, Wei Li, Masashi Takeda, Takayuki Goto, Kosuke Kawaguchi, Taka‐Aki Sato, Masakazu Toi   +10 more
wiley   +1 more source

Glycosphingolipids in human parasites

FEBS Open Bio, Volume 13, Issue 9, Page 1625-1635, September 2023., 2023
The parasites that infect humans and animals include protozoans and helminths (worms). Their secretions and cellular membranes contain complex glycomolecules including glycoproteins and glycolipids. A class of glycolipids shared between humans and parasites are the glycosphingolipids (GSLs) containing a lipid (ceramide) linked to a glycan ...
Richard D. Cummings
wiley   +1 more source

APOE ε2 resilience for Alzheimer's disease is mediated by plasma lipid species: Analysis of three independent cohort studies

Alzheimer's &Dementia, Volume 18, Issue 11, Page 2151-2166, November 2022., 2022
Abstract Introduction The apolipoprotein E (APOE) genotype is the strongest genetic risk factor for late‐onset Alzheimer's disease. However, its effect on lipid metabolic pathways, and their mediating effect on disease risk, is poorly understood. Methods We performed lipidomic analysis on three independent cohorts (the Australian Imaging, Biomarkers ...
Tingting Wang, Kevin Huynh, Corey Giles, Natalie A Mellett, Thy Duong, Anh Nguyen, Wei Ling Florence Lim, Alex AT Smith, Gavriel Olshansky, Gemma Cadby, Joseph Hung, Jennie Hui, John Beilby, Gerald F Watts, Pratishtha Chatterjee, Ian Martins, Simon M Laws, Ashley I Bush, Christopher C Rowe, Victor L Villemagne, David Ames, Colin L Masters, Kevin Taddei, Vincent Doré, Jürgen Fripp, Matthias Arnold, Gabi Kastenmüller, Kwangsik Nho, Andrew J Saykin, Rebecca Baillie, Xianlin Han, Ralph N Martins, Eric K Moses, Rima Kaddurah‐Daouk, Peter J Meikle   +34 more
wiley   +1 more source

Correlation between metabolomic profile constituents and feline pancreatic lipase immunoreactivity

Journal of Veterinary Internal Medicine, Volume 36, Issue 2, Page 473-481, March 2022., 2022
Abstract Background Feline pancreatic lipase immunoreactivity (fPLI) is commonly used to diagnose pancreatitis in cats (FP). Untargeted metabolomics has been extensively applied in human and veterinary medicine, but no metabolomic studies regarding FP have been conducted.
Magdalena Maria Krasztel, Michał Czopowicz, Olga Szaluś‐Jordanow, Agata Moroz, Marcin Mickiewicz, Jarosław Kaba   +5 more
wiley   +1 more source

HDL-mimetic peptide treatment reverses APOE4-induced transcriptomic and lipidomic alterations in the brain of humanized APOE mice. [PDF]

Alzheimers Dement
Abstract INTRODUCTION The apolipoprotein E4 (APOE4) allele is the strongest genetic risk factor for late‐onset Alzheimer's disease (AD). ApoE4 has reduced lipidation capacity and impaired lipid transport, disrupting neuronal maintenance. The high‐density lipoprotein (HDL)‐mimetic peptide 4F offers a potential therapeutic strategy.
Chang A, Kim M, Glittenberg M, Qu W, Li D, Li L.   +5 more
europepmc   +2 more sources

Metabolite Characteristics in Tongue Coating from Damp Phlegm Pattern in Patients with Gastric Precancerous Lesion

Evidence-Based Complementary and Alternative Medicine, Volume 2021, Issue 1, 2021., 2021
Objective. In this study, we analyzed the metabolite profile of the tongue coating of patients having gastric precancerous lesion (GPL) with damp phlegm pattern and proposed a mechanism of pathological transition. Methods. The changes in tongue‐coating metabolites in patients with GPL damp phlegm pattern were analyzed using GC‐TOF‐MS and UHPLC‐QE‐MS ...
Yifeng Xu, Renling Zhang, Robert Morris, Feng Cheng, Yiqin Wang, Zhujing Zhu, Yiming Hao, Yu CAI   +7 more
wiley   +1 more source

Small Extracellular Vesicle and Total Lipid Profiles Provide a Diagnostic Advantage Over CA‐125 Across Ovarian Cancer Subtypes

Journal of Extracellular Vesicles, Volume 15, Issue 9, September 2026.
Small extracellular vesicle (sEV) lipid profiles outperform CA‐125 across ovarian cancer histotypes, achieving accuracy up to 0.73 in differential diagnosis and 0.94 in screening. In patients with normal CA‐125 levels, sEV lipids maintain discriminative performance where CA‐125 alone fails. ABSTRACT Ovarian cancer remains the most lethal gynaecological
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Lewis Perrin, Rohan Lourie, Vaibhavi Joshi, Amy E. McCart Reed, Kaltin Ferguson, Aase Handberg, Andreas Möller, Carlos Salomon   +11 more
wiley   +1 more source

Role of Sphingolipids in the Pathobiology of Lung Inflammation

Mediators of Inflammation, Volume 2015, Issue 1, 2015., 2015
Sphingolipid bioactivities in the respiratory airways and the roles of the proteins that handle them have been extensively investigated. Gas or inhaled particles or microorganisms come into contact with mucus components, epithelial cells, blood barrier, and immune surveillance within the airways.
Riccardo Ghidoni, Anna Caretti, Paola Signorelli, Ashley Snider   +3 more
wiley   +1 more source

Mechanistic Landscape and Farm to Fork Control Strategies for Streptococcus suis: An Emerging Foodborne Threat

Transboundary and Emerging Diseases, Volume 2026, Issue 1, 2026.
Streptococcus suis (S. suis) is an emerging zoonotic agent that now rivals classical food‐borne pathogens in its global clinical burden of meningitis and septic shock. Recent epidemiological syntheses covering more than 30 countries now list over 1600 laboratory‐confirmed human cases with a pooled case‐fatality of about 12%, climbing beyond 18% in East
Wangyuan Yao, Meili Chen, Hongkai Ren, Qingqing Luo, Xuyuan Wang, Md. Akhtar, Zeeshan Ahmad Bhutta, Lianci Peng, Muhammad Yasir Nawaz, Mohammad Mehedi Hasan, Md. F. Kulyar, Rendong Fang, Zhong Peng   +12 more
wiley   +1 more source