Results 21 to 30 of about 19,114 (240)

Subthalamic Peak Beta Ratio Is Asymmetric in Glucocerebrosidase Mutation Carriers With Parkinson's Disease: A Pilot Study

Frontiers in Neurology, 2021
Introduction: Up to 27% of individuals undergoing subthalamic nucleus deep brain stimulation (STN-DBS) have a genetic form of Parkinson's disease (PD).
Fabian J. David, Miranda J. Munoz, Jay L. Shils, Michael W. Pauciulo, Philip T. Hale, William C. Nichols, Mitra Afshari, Sepehr Sani, Leo Verhagen Metman, Daniel M. Corcos, Gian D. Pal, Gian D. Pal   +11 more
doaj   +1 more source

Transcriptome deregulation of peripheral monocytes and whole blood in GBA-related Parkinson’s disease

Molecular Neurodegeneration, 2022
Background Genetic mutations in beta-glucocerebrosidase (GBA) represent the major genetic risk factor for Parkinson’s disease (PD). GBA participates in both the endo-lysosomal pathway and the immune response, two important mechanisms involved in the ...
Giulietta Maria Riboldi, Ricardo A. Vialle, Elisa Navarro, Evan Udine, Katia de Paiva Lopes, Jack Humphrey, Amanda Allan, Madison Parks, Brooklyn Henderson, Kelly Astudillo, Charalambos Argyrou, Maojuan Zhuang, Tamjeed Sikder, J. Oriol Narcis, Shilpa Dilip Kumar, William Janssen, Allison Sowa, Giacomo P. Comi, Alessio Di Fonzo, John F. Crary, Steven J. Frucht, Towfique Raj   +21 more
doaj   +1 more source

Production Logistics in Industry 3.X: Bibliometric Analysis, Frontier Case Study, and Future Directions

Systems, 2023
At present, the development of the global manufacturing industry is still in the transition stage from Industry 3.0 to Industry 4.0 (i.e., Industry 3.X), and the production logistics system is becoming more and more complex due to the individualization ...
Honglin Yi, Ting Qu, Kai Zhang, Mingxing Li, George Q. Huang, Zefeng Chen   +5 more
doaj   +1 more source

A NOVEL SYNTHETIC AND RECOMBINANT GLUCOCEREBROSIDASE FOR GAUCHER DISEASE: IN SILICO MOLECULAR EVOLUTION AND GENE THERAPY APPROACHES TO ENHANCE ENZYME ACTIVITY

Hematology, Transfusion and Cell Therapy, 2023
Background: Gaucher disease (GD) is a rare lysosomal storage disease caused by pathogenic variants in the glucocerebrosidase gene (GBA1) resulting in a markedly decreased activity of the lysosomal enzyme b-glucocerebrosidase (GCase).
LLS Figueiredo, LEB Souza, MD Orellana, DT Covas, F Lichtenstein, V Siciliano, KJ Abraham, R Weiss, SL Gerson, AM Fontes   +9 more
doaj   +1 more source

Targeted delivery of galbanic acid to colon cancer cells by PLGA nanoparticles incorporated into human mesenchymal stem cells [PDF]

Avicenna Journal of Phytomedicine, 2022
Objective: The aim of this study was to investigate the efficacy of mesenchyme stem cells (MSCs) derived from human adipose tissue (hMSCs) as carriers for delivery of galbanic acid (GBA), a potential anticancer agent, loaded into poly (lactic-co-glycolic
Mahboubeh Ebrahimian, Sanaz Shahgordi, Rezvan Yazdian-Robati, Leila Etemad, Maryam Hashemi, Zahra Salmasi   +5 more
doaj   +1 more source

The Consequences of GBA Deficiency in the Autophagy–Lysosome System in Parkinson’s Disease Associated with GBA

Cells, 2023
GBA gene variants were the first genetic risk factor for Parkinson’s disease. GBA encodes the lysosomal enzyme glucocerebrosidase (GBA), which is involved in sphingolipid metabolism.
Eddie Pradas, Marta Martinez-Vicente
doaj   +1 more source

α-Synuclein accumulation and GBA deficiency due to L444P GBA mutation contributes to MPTP-induced parkinsonism

Molecular Neurodegeneration, 2018
Background Mutations in glucocerebrosidase (GBA) cause Gaucher disease (GD) and increase the risk of developing Parkinson’s disease (PD) and Dementia with Lewy Bodies (DLB).
Seung Pil Yun, Donghoon Kim, Sangjune Kim, SangMin Kim, Senthilkumar S. Karuppagounder, Seung-Hwan Kwon, Saebom Lee, Tae-In Kam, Suhyun Lee, Sangwoo Ham, Jae Hong Park, Valina L. Dawson, Ted M. Dawson, Yunjong Lee, Han Seok Ko   +14 more
doaj   +1 more source

The Impact of Maternal Gut Microbiota during Pregnancy on Fetal Gut–Brain Axis Development and Life-Long Health Outcomes

Microorganisms, 2023
Gut microbiota plays a critical role in physiological regulation throughout life and is specifically modified to meet the demands of individual life stages and during pregnancy.
Elizabeth M. Sajdel-Sulkowska
doaj   +1 more source

Cloud-Edge-Terminal-Based Synchronized Decision-Making and Control System for Municipal Solid Waste Collection and Transportation

Mathematics, 2022
Due to dynamics caused by factors such as random collection and transportation requirements, vehicle failures, and traffic jams, it is difficult to implement regular waste collection and transportation schemes effectively.
Ming Wan, Ting Qu, Manna Huang, Xiaohua Qiu, George Q. Huang, Jinfu Zhu, Junrong Chen   +6 more
doaj   +1 more source

Unraveling neurotransmitter changes in de novo GBA-related and idiopathic Parkinson's disease

Neurobiology of Disease, 2023
Background: Presently, neurotransmitter deficits in GBA-related Parkinson's disease (GBA-PD) and relationships with cognitive impairment are poorly understood.
Jingru Ren, Lei Yan, Hao Zhou, Chenxi Pan, Chen Xue, Jun Wu, Weiguo Liu   +6 more
doaj   +1 more source