Results 1 to 10 of about 18,064 (218)

The Consequences of GBA Deficiency in the Autophagy–Lysosome System in Parkinson’s Disease Associated with GBA

Cells, 2023
GBA gene variants were the first genetic risk factor for Parkinson’s disease. GBA encodes the lysosomal enzyme glucocerebrosidase (GBA), which is involved in sphingolipid metabolism.
Marta Martínez-Vicente, Martínez-Vicente Marta   +1 more
exaly   +6 more sources

Modelling cholinergic and dopaminergic function over time in Parkinson’s disease with and without GBA1 variants [PDF]

npj Parkinson's Disease
Parkinson’s Disease (PD) patients carrying GBA1-variants (GBA-PD) often show a faster cognitive decline, suggesting accelerated cholinergic degeneration.
Sofie Slingerland, Eline K. R. de Meyer, Harm J. van der Horn, Giulia Carli, Anne C. Slomp, Emile d’Angremont, Jeffrey M. Boertien, Ingeborg Goethals, Sanne K. Meles, Sygrid van der Zee, Teus van Laar   +10 more
doaj   +2 more sources

A Multi-Target Detection Method Based on Improved U-Net for UWB MIMO Through-Wall Radar

Remote Sensing, 2023
Ultra-wideband (UWB) multiple-input multiple-output (MIMO) through-wall radar is widely used in through-wall human target detection for its good penetration characteristics and resolution.
Jun Pan, Zhijie Zheng, Di Zhao, Kun Yan, Jinliang Nie, Bin Zhou, Guangyou Fang   +6 more
doaj   +1 more source

The Usage of GIS Tools on Vintage Aerogeophysical Data for Simple and Fast Processing with a Focus on Fault Interpretation: An Austrian Case Study

Geosciences, 2022
The reuse of vintage datasets which were acquired in the 20th century can pose challenges for modern geophysical modeling due to missing detailed preprocessing information, significant uncertainties, or lack of precise tracking, etc.
Ingrid Schattauer, Esther Hintersberger, Christian Ullrich, Robert Supper, Klaus Motschka   +4 more
doaj   +1 more source

Gene Expression of Lysosomal Membrane Proteins in Parkinson Disease, Associated with Mutations in the Glucocerebrosidase Gene (GBA)

Анналы клинической и экспериментальной неврологии, 2020
Introduction. In carriers of a mutation in the lysosomal enzyme glucocerebrosidase (GBA) gene, the risk of Parkinson disease (PD) is increased by 78 times. However, not all carriers of the GBA gene mutations develop PD during their lifetime.
Tatiana S. Usenko, Anastasia I. Bezrukova, Darya A. Bogdanova, Mikhail A. Nikolaev, Irina V. Miliukhina, Elizaveta V. Gracheva, Konstantin A. Senkevich, Ekaterina Yu. Zakharova, Anton K. Emelyanov, Sofya N. Pchelina   +9 more
doaj   +1 more source

Three-Dimensional Motion Compensation Method Based on Sparse Array Designed for Time-Division Multiplexing Multiple-Input-Multiple-Output Through-Wall Radar

Applied Sciences, 2023
A large-aperture radar composed of a multiple-input-multiple-output (MIMO) planar array can complete 3D through-wall imaging (TWI), but the simultaneous work of the multiple transceiver channels leads to difficulties in designing the hardware.
Jun Pan, Xiao Liang, Shiyou Wu, Di Zhao, Kun Yan, Jinliang Nie, Jianmin Hu, Bin Zhou, Guangyou Fang   +8 more
doaj   +1 more source

Solving Color Reproducibility between Digital Devices: A Robust Approach of Smartphones Color Management for Chemical (Bio)Sensors

Biosensors, 2022
In the past twelve years, digital image colorimetry (DIC) on smartphones has acquired great importance as an alternative to the most common analytical techniques.
Pablo Cebrián, Leticia Pérez-Sienes, Isabel Sanz-Vicente, Ángel López-Molinero, Susana de Marcos, Javier Galbán   +5 more
doaj   +1 more source

Cognition as a mediator for gait and balance impairments in GBA-related Parkinson’s disease

npj Parkinson's Disease, 2022
The extent to which the heterogeneity of gait and balance problems in PD may be explained by genetic variation is unknown. Variants in the glucocerebrosidase (GBA) gene are the strongest known genetic risk factor for PD and are associated with greater ...
Rosie Morris, Douglas N. Martini, Katrina Ramsey, Valerie E. Kelly, Katrijn Smulders, Amie Hiller, Kathryn A. Chung, Shu-Ching Hu, Cyrus P. Zabetian, Kathleen L. Poston, Ignacio F. Mata, Karen L. Edwards, Jodi Lapidus, Brenna Cholerton, Thomas J. Montine, Joseph F. Quinn, Fay Horak   +16 more
doaj   +1 more source

Cognitive Functioning of Glucocerebrosidase (GBA) Non-manifesting Carriers

Frontiers in Neurology, 2021
Mutations and variants in the glucocerebrosidase (GBA) gene are among the most common genetic risk factors for the development of Parkinson's disease (PD).
Eileen E. Moran, Eileen E. Moran, Susan B. Bressman, Susan B. Bressman, Roberto A. Ortega, Roberto A. Ortega, Deborah Raymond, Deborah Raymond, William C. Nichols, Christina A. Palmese, Christina A. Palmese, Sonya Elango, Sonya Elango, Matthew Swan, Matthew Swan, Vicki Shanker, Vicki Shanker, Imali Perera, Cuiling Wang, Molly E. Zimmerman, Rachel Saunders-Pullman, Rachel Saunders-Pullman   +21 more
doaj   +1 more source

Fibroblasts from idiopathic Parkinson’s disease exhibit deficiency of lysosomal glucocerebrosidase activity associated with reduced levels of the trafficking receptor LIMP2

Molecular Brain, 2021
Lysosomal dysfunction is a central pathway associated with Parkinson’s disease (PD) pathogenesis. Haploinsufficiency of the lysosomal hydrolase GBA (encoding glucocerebrosidase (GCase)) is one of the largest genetic risk factors for developing PD ...
Ria Thomas, Elizabeth B. Moloney, Zachary K. Macbain, Penelope J. Hallett, Ole Isacson   +4 more
doaj   +1 more source