Results 1 to 10 of about 17,871 (218)

The Consequences of GBA Deficiency in the Autophagy–Lysosome System in Parkinson’s Disease Associated with GBA

Cells, 2023
GBA gene variants were the first genetic risk factor for Parkinson’s disease. GBA encodes the lysosomal enzyme glucocerebrosidase (GBA), which is involved in sphingolipid metabolism.
Marta Martínez-Vicente, Martínez-Vicente Marta   +1 more
exaly   +6 more sources

Association of GBA genotype with motor and cognitive decline in Chinese Parkinson’s disease patients

Frontiers in Aging Neuroscience, 2023
ObjectiveVariants in the glucocerebrosidase (GBA) gene are the most common and significant risk factor for Parkinson’s disease (PD). However, the impact of GBA variants on PD disease progression in the Chinese population remains unclear. This study aimed
Jingru Ren, Huifen Zheng, Ren Jingru
exaly   +3 more sources

Modelling cholinergic and dopaminergic function over time in Parkinson’s disease with and without GBA1 variants [PDF]

npj Parkinson's Disease
Parkinson’s Disease (PD) patients carrying GBA1-variants (GBA-PD) often show a faster cognitive decline, suggesting accelerated cholinergic degeneration.
Sofie Slingerland, Eline K. R. de Meyer, Harm J. van der Horn, Giulia Carli, Anne C. Slomp, Emile d’Angremont, Jeffrey M. Boertien, Ingeborg Goethals, Sanne K. Meles, Sygrid van der Zee, Teus van Laar   +10 more
doaj   +2 more sources

The SPID-GBA study [PDF]

Neurology Genetics, 2020
To provide a variant-specific estimate of incidence, penetrance, sex distribution, and association with dementia of the 4 most common Parkinson disease (PD)-associated GBA variants, we analyzed a large cohort of 4,923 Italian unrelated patients with primary degenerative parkinsonism (including 3,832 PD) enrolled in a single tertiary care center and 7 ...
Letizia Straniero, Rosanna Asselta, Salvatore Bonvegna, Valeria Rimoldi, Giada Melistaccio, Giulia Soldà, Massimo Aureli, Matteo Della Porta, Ugo Lucca, Alessio Di Fonzo, Anna Zecchinelli, Gianni Pezzoli, Roberto Cilia, Stefano Duga   +13 more
openaire   +2 more sources

A Multi-Target Detection Method Based on Improved U-Net for UWB MIMO Through-Wall Radar

Remote Sensing, 2023
Ultra-wideband (UWB) multiple-input multiple-output (MIMO) through-wall radar is widely used in through-wall human target detection for its good penetration characteristics and resolution.
Jun Pan, Zhijie Zheng, Di Zhao, Kun Yan, Jinliang Nie, Bin Zhou, Guangyou Fang   +6 more
doaj   +1 more source

The Usage of GIS Tools on Vintage Aerogeophysical Data for Simple and Fast Processing with a Focus on Fault Interpretation: An Austrian Case Study

Geosciences, 2022
The reuse of vintage datasets which were acquired in the 20th century can pose challenges for modern geophysical modeling due to missing detailed preprocessing information, significant uncertainties, or lack of precise tracking, etc.
Ingrid Schattauer, Esther Hintersberger, Christian Ullrich, Robert Supper, Klaus Motschka   +4 more
doaj   +1 more source

Gene Expression of Lysosomal Membrane Proteins in Parkinson Disease, Associated with Mutations in the Glucocerebrosidase Gene (GBA)

Анналы клинической и экспериментальной неврологии, 2020
Introduction. In carriers of a mutation in the lysosomal enzyme glucocerebrosidase (GBA) gene, the risk of Parkinson disease (PD) is increased by 78 times. However, not all carriers of the GBA gene mutations develop PD during their lifetime.
Tatiana S. Usenko, Anastasia I. Bezrukova, Darya A. Bogdanova, Mikhail A. Nikolaev, Irina V. Miliukhina, Elizaveta V. Gracheva, Konstantin A. Senkevich, Ekaterina Yu. Zakharova, Anton K. Emelyanov, Sofya N. Pchelina   +9 more
doaj   +1 more source

Solving Color Reproducibility between Digital Devices: A Robust Approach of Smartphones Color Management for Chemical (Bio)Sensors

Biosensors, 2022
In the past twelve years, digital image colorimetry (DIC) on smartphones has acquired great importance as an alternative to the most common analytical techniques.
Pablo Cebrián, Leticia Pérez-Sienes, Isabel Sanz-Vicente, Ángel López-Molinero, Susana de Marcos, Javier Galbán   +5 more
doaj   +1 more source

Three-Dimensional Motion Compensation Method Based on Sparse Array Designed for Time-Division Multiplexing Multiple-Input-Multiple-Output Through-Wall Radar

Applied Sciences, 2023
A large-aperture radar composed of a multiple-input-multiple-output (MIMO) planar array can complete 3D through-wall imaging (TWI), but the simultaneous work of the multiple transceiver channels leads to difficulties in designing the hardware.
Jun Pan, Xiao Liang, Shiyou Wu, Di Zhao, Kun Yan, Jinliang Nie, Jianmin Hu, Bin Zhou, Guangyou Fang   +8 more
doaj   +1 more source

Cognitive Functioning of Glucocerebrosidase (GBA) Non-manifesting Carriers

Frontiers in Neurology, 2021
Mutations and variants in the glucocerebrosidase (GBA) gene are among the most common genetic risk factors for the development of Parkinson's disease (PD).
Eileen E. Moran, Eileen E. Moran, Susan B. Bressman, Susan B. Bressman, Roberto A. Ortega, Roberto A. Ortega, Deborah Raymond, Deborah Raymond, William C. Nichols, Christina A. Palmese, Christina A. Palmese, Sonya Elango, Sonya Elango, Matthew Swan, Matthew Swan, Vicki Shanker, Vicki Shanker, Imali Perera, Cuiling Wang, Molly E. Zimmerman, Rachel Saunders-Pullman, Rachel Saunders-Pullman   +21 more
doaj   +1 more source