Results 31 to 40 of about 17,871 (218)

Post-translational proteomics platform identifies neurite outgrowth impairments in Parkinson’s disease GBA-N370S dopamine neurons

Cell Reports, 2023
Summary: Variants at the GBA locus, encoding glucocerebrosidase, are the strongest common genetic risk factor for Parkinson’s disease (PD). To understand GBA-related disease mechanisms, we use a multi-part-enrichment proteomics and post-translational ...
Helle Bogetofte, Brent J. Ryan, Pia Jensen, Sissel I. Schmidt, Dana L.E. Vergoossen, Mike B. Barnkob, Lisa N. Kiani, Uroosa Chughtai, Rachel Heon-Roberts, Maria Claudia Caiazza, William McGuinness, Ricardo Márquez-Gómez, Jane Vowles, Fiona S. Bunn, Janine Brandes, Peter Kilfeather, Jack P. Connor, Hugo J.R. Fernandes, Tara M. Caffrey, Morten Meyer, Sally A. Cowley, Martin R. Larsen, Richard Wade-Martins   +22 more
doaj   +1 more source

Deep Ultraviolet Dual Comb from a Thin-Disk Laser

Ultrafast Science
Dual-comb spectroscopy provides a marked advantage over single-comb techniques for molecular fingerprinting, particularly in terms of scanning speed. The single-cavity dual-comb system is a simpler approach to dual-comb operation.
Quanming Li, Hanze Bai, Xiaodan Teng, Hongshan Chen, Haijing Mai, Zhitao Zhang, Jinwei Zhang, Hongwen Xuan   +7 more
doaj   +1 more source

Influence of femoral tunnel exit on the 3D graft bending angle in anterior cruciate ligament reconstruction

Journal of Experimental Orthopaedics, 2021
Purpose To quantify the influence of the femoral tunnel exit (FTE) on the graft bending angle (GBA) and GBA‐excursion throughout a full range of motion (ROM) in single‐bundle anterior cruciate ligament (ACL) reconstruction. Methods Three‐dimensional (3D)
Sandro Hodel, Sylvano Mania, Lazaros Vlachopoulos, Philipp Fürnstahl, Sandro F. Fucentese   +4 more
doaj   +1 more source

Cloud-Edge-Terminal-Based Synchronized Decision-Making and Control System for Municipal Solid Waste Collection and Transportation

Mathematics, 2022
Due to dynamics caused by factors such as random collection and transportation requirements, vehicle failures, and traffic jams, it is difficult to implement regular waste collection and transportation schemes effectively.
Ming Wan, Ting Qu, Manna Huang, Xiaohua Qiu, George Q. Huang, Jinfu Zhu, Junrong Chen   +6 more
doaj   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Intelligent Systems for Inorganic Nanomaterial Synthesis

Nanomaterials
Inorganic nanomaterials are pivotal foundational materials driving traditional industries’ transformation and emerging sectors’ evolution. However, their industrial application is hindered by the limitations of conventional synthesis methods, including ...
Chang’en Han, Xinghua Dong, Wang Zhang, Xiaoxia Huang, Linji Gong, Chunjian Su   +5 more
doaj   +1 more source

Expanding the Utility of Exome Sequencing in Preventive and Population Genetics

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Carrier screening is a long‐standing genetic testing process offered to at‐risk couples, with or without a family history, who might have pregnancies affected by an autosomal recessive (AR) or X‐linked (XL) disorder. A total of 276 unrelated individuals, initially referred for rare disorder screening by clinicians, were enrolled in this study ...
Charilaos Kostoulas, Athanasia Sesse, Ioanna Bouba, Robert Najdecki, Spyridon Konitsiotis, Sofia Markoula, Ioannis Georgiou   +6 more
wiley   +1 more source

The middle-income trap and the middle-technology trap in Latin America–practice comparison based on East Asian perspective

Asian Review of Political Economy
Most Latin American countries entered the ranks of middle-income levels almost simultaneously with Japan and South Korea. However, while Japan and South Korea embarked on the path of economic development through technological innovation and industrial ...
Qiuju Wu, Weichuang Fang
doaj   +1 more source

Study on Pre-Clinical In-Vitro Test Methods of Unicondylar Knee Prosthesis

Zhongguo yiliao qixie zazhi
Compared with total knee arthroplasty, unicondylar knee replacement has the advantage of preserving the knee tissue structure and motor function to the greatest extent.
Shu YANG, Dan HAN, Wen CUI, Zhenxian CHEN, Jinju DING, Jintao GAO, Bin LIU   +6 more
doaj   +1 more source

Exosome‐mediated gut–brain axis signaling in neurodegenerative diseases: Mechanisms, experimental evidence, and therapeutic perspectives—A narrative review

Animal Models and Experimental Medicine, EarlyView.
The gut–brain axis is a bidirectional communication network between the intestines and brain, mediated by gut microbiota and exosomes, that regulates neuroinflammation, protein aggregation, and neuronal health processes central to neurodegenerative diseases.
Waheeb Sami Aggad, Rakesh Ghosh, Hailah M. Almohaimeed, Zuhair M. Mohammedsaleh, Fayez M. Saleh, Amany I. Almars, S. Renuka Jyothi, Rajashree Panigrahi, Ajoy Kumer, Bikram Dhara   +9 more
wiley   +1 more source