Results 51 to 60 of about 25,057 (208)

Biochemical Characteristics of iPSC-Derived Dopaminergic Neurons from N370S GBA Variant Carriers with and without Parkinson’s Disease

, 2023
GBA variants increase the risk of Parkinson’s disease (PD) by 10 times. The GBA gene encodes the lysosomal enzyme glucocerebrosidase (GCase). The p.N370S substitution causes a violation of the enzyme conformation, which affects its stability in the
Tuyana B. Malankhanova, Galina V. Baydakova, Elena V. Grigor’eva, Alena E. Kopytova, Ekaterina Y. Zakharova, Anastasia A. Malakhova, Diana A. Sorogina, Suren M. Zakian, Sophia V. Pavlova, Elena S. Yarkova, Sergey P. Medvedev, Sofia N. Pchelina   +11 more
core   +1 more source

microRNA‐7‐5p and α‐Synuclein SAA Predict Parkinson's Disease Phenoconversion

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Corroborate blood neuron‐derived extracellular vesicle (NDEV) alpha‐synuclein (αSyn), the CSF αSyn seed amplification assay (αSyn‐SAA), and blood microRNA‐7‐5p (miR‐7‐5p) as markers for Parkinson's disease (PD) phenoconversion and determine if combining these markers would help select subjects who would be more likely to phenoconvert.
Shayan Zadegan, Praveen Velammal, Kanmani Muthiah, Madhu Jatty, Christopher Adams   +4 more
wiley   +1 more source

Genre Based Approach (GBA) in Teacher's Module at Senior High School Phase E [PDF]

, 2023
This research is written to describe the application of Genre Based Approach (GBA) in teaching English as the implementation Merdeka Curriculum at Senior High School.
Puspita, Dela, Afriyanti, Rika
core   +2 more sources

The Impact of Maternal Gut Microbiota during Pregnancy on Fetal Gut–Brain Axis Development and Life-Long Health Outcomes

Microorganisms, 2023
Gut microbiota plays a critical role in physiological regulation throughout life and is specifically modified to meet the demands of individual life stages and during pregnancy.
Elizabeth M. Sajdel-Sulkowska
doaj   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Study on Pre-Clinical In-Vitro Test Methods of Unicondylar Knee Prosthesis

Zhongguo yiliao qixie zazhi
Compared with total knee arthroplasty, unicondylar knee replacement has the advantage of preserving the knee tissue structure and motor function to the greatest extent.
Shu YANG, Dan HAN, Wen CUI, Zhenxian CHEN, Jinju DING, Jintao GAO, Bin LIU   +6 more
doaj   +1 more source

Magnetoelectric Nanoparticles Enable Modulation of Cortical Networks by Low‐Intensity Static Magnetic Fields In Vitro

Advanced Science, EarlyView.
Neuromodulation strategies are increasingly needed to stimulate, restore, or replace altered neuronal activity in disease. Cobalt ferrite‐barium titanate (CFO–BTO) magnetoelectric nanoparticles convert low‐intensity static magnetic fields into local electrical modulation of cortical networks.
Nathalia Cancino‐Fuentes, Alejandro Suarez‐Perez, Elric Zhang, Hao Ye, Marta Bonato, Joana Covelo, Vitaly Pustovalov, Anton Guimera‐Brunet, Xavi Illa, Valentin Gantenbein, Cagatay M. Oral, Marta Parazzini, Salvador Pané, Maria V. Sanchez‐Vives   +13 more
wiley   +1 more source

Grand-averaged amplitude and latency of GBA.

, 2013
All values are mean and standard deviation (in parenthesis) of GBA.Abbreviations used: GBA, gamma-band activity; a.u., arbitrary unit; RLS, restless leg syndrome; ROI, region of interest.
Kyung Hwan Kim (313939), Ki-Young Jung (313938), Jeong Woo Choi (313935), Deokwon Ko (313936), Gwan-Taek Lee (313937)   +4 more
core   +1 more source

The middle-income trap and the middle-technology trap in Latin America–practice comparison based on East Asian perspective

Asian Review of Political Economy
Most Latin American countries entered the ranks of middle-income levels almost simultaneously with Japan and South Korea. However, while Japan and South Korea embarked on the path of economic development through technological innovation and industrial ...
Qiuju Wu, Weichuang Fang
doaj   +1 more source

Research Progress of Terahertz Technology in Microbiology

Biosensors
Microorganisms are ubiquitous in nature, and microbial activities are closely intertwined with the entire life cycle system and human life. Developing novel technologies for the detection, characterization and manipulation of microorganisms promotes ...
Ding Cao, Ruibing Dong, Guangyou Fang, Xuequan Chen   +3 more
doaj   +1 more source