Results 51 to 60 of about 17,871 (218)

Patients’ experiences of Parkinson’s disease: a qualitative study in glucocerebrosidase and idiopathic Parkinson’s disease

Journal of Patient-Reported Outcomes, 2020
Background Approximately 7–10% of Parkinson’s disease (PD) patients carry a GBA (Glucocerebrosidase) mutation (GBA-PD patients), which may influence the disease’s clinical course.
N. Bonner, S. Bozzi, L. Morgan, B. Mason, M. J. Peterschmitt, T. Z. Fischer, R. Arbuckle, M. Reaney   +7 more
doaj   +1 more source

Gambogic acid inhibits LPS-induced macrophage pro-inflammatory cytokine production mainly through suppression of the p38 pathway [PDF]

Iranian Journal of Basic Medical Sciences, 2018
Objective(s): In traditional Chinese medicine, gamboge can detoxify bodies, kill parasites, and act as a hemostatic agent. Recent studies have demonstrated that gambogic acid (GBA) suppressed inflammation in arthritis, and also presented antitumor effect.
Ma Jianjun, Kangmao Huang, Yan Ma, Shuai Chen, Chao Liu, Zhi Shan, Xiangqian Fang   +6 more
doaj   +1 more source

First National Expanded Genomic Newborn Screening Program in Qatar; A Pilot Study, Doha‐Heidelberg Collaboration

American Journal of Medical Genetics Part A, EarlyView.
Reem Alsulaiman, Sarah Okashah, Radja Messai Badji, Fatemeh Abbaszadeh, Yaser Alsarraj, Rehab Ali Abdulrahman, Noora Shahbeck, Thalib Moideen, Reema El Hassan, Fatima Al‐Hamaydeh, Einas Alkuwari, Said Ismail, Hilal Al‐ Rifai, Ghassan Abdoh, Christian P. Schaaf, Georg Hoffmann, Saad Al‐Kaabi, Wadha Al‐Muftah, Tawfeg Ben‐Omran   +18 more
wiley   +1 more source

Polycarbazole–NiOOH Interfacial Engineering of BiVO4 Photoanodes for Efficient and Stable Solar Water Splitting

ENERGY &ENVIRONMENTAL MATERIALS, EarlyView.
A π‐conjugated carbazole (p‐CBZ) layer is electro‐polymerized on BiVO4 to form a p–n heterojunction that enhances charge separation and suppresses surface recombination, while a NiOOH co‐catalyst accelerates oxygen evolution kinetics. The synergistic BVO/p‐CBZ/NiOOH photoanode delivers a high photocurrent density and long‐term stability for efficient ...
Lakshman Sundar Arumugam, Ana Gutierrez‐Blanco, Agustin O. Alvarez, Alejandro Saura Aviles, Mahesh Eledath‐Changarath, Rafael Abargues, Juan Francisco Sánchez‐Royo, Helena Rabelo, Maria Chiara Spadaro, Jordi Arbiol, Javier E. Durantini, Sixto Giménez   +11 more
wiley   +1 more source

Influence of Graft Bending Angle on Graft Maturation, the Femoral Tunnel, and Functional Outcomes by 12 Months After Anterior Cruciate Ligament Reconstruction

Orthopaedic Journal of Sports Medicine, 2019
Background: The graft bending angle (GBA), the angle between the femoral bone tunnel and the line connecting the femoral and tibial tunnel apertures, has been proven to influence stress within the graft and could be an important factor in graft healing ...
Hong Li MD, Shaohua Liu MD, Yaying Sun MD, Hongyun Li MD, Shiyi Chen MD, PhD, Jiwu Chen PhD   +5 more
doaj   +1 more source

Genetic epilepsies with myoclonic seizures: Mechanisms and syndromes

Epilepsia Open, EarlyView.
Abstract Genetic epilepsy with myoclonic seizures encompasses a heterogeneous spectrum of conditions, ranging from benign and self‐limiting forms to severe, progressive disorders. While their causes are diverse, a significant proportion stems from genetic abnormalities.
Antonietta Coppola, Marica Rubino, Antonella Riva, Pasquale Striano   +3 more
wiley   +1 more source

Distinctive cognitive phenotypes in Parkinson’s disease patients with GBA mutations and without dementia: a multicentre cross-sectional retrospective study

Clinical Parkinsonism & Related Disorders
Background: Cognitive impairment is a major non-motor complication of Parkinson’s disease (PD). GBA mutations are associated with an increased risk, with PD-GBA+ patients typically showing earlier disease onset and faster cognitive decline.
Chiara Longo, Marco Liccari, Ruggero Bacchin, Costanza Papagno, Donatella Ottaviani, Raffaella Di Giacopo, Mauro Catalan, Alina Menichelli, Massimo Marano, Alessio Di Fonzo, Giovanni Duro, Carmela Zizzo, Paolo Manganotti, Bruno Giometto, Maria Chiara Malaguti   +14 more
doaj   +1 more source

Cross-talks among GBA mutations, glucocerebrosidase, and α-synuclein in GBA-associated Parkinson’s disease and their targeted therapeutic approaches: a comprehensive review

Translational Neurodegeneration, 2021
Current therapies for Parkinson’s disease (PD) are palliative, of which the levodopa/carbidopa therapy remains the primary choice but is unable to modulate the progression of neurodegeneration.
Tapan Behl, Gagandeep Kaur, Ovidiu Fratila, Camelia Buhas, Claudia Teodora Judea-Pusta, Nicoleta Negrut, Cristiana Bustea, Simona Bungau   +7 more
doaj   +1 more source

Classification of GBA Variants and Their Effects in Synucleinopathies

Movement Disorders, 2019
This is the peer reviewed version of the following article: [Gan‐Or, Z., Alcalay, R.N., Makarious, M.B., Scholz, S.W., and Blauwendraat, C. (2019). Classification of GBA Variants and Their Effects in Synucleinopathies. Movement Disorders 34, 1581–1582.], which has been published in final form at https://doi.org/10.1002/mds.27803.
Gan‐Or, Ziv, Alcalay, Roy N., Makarious, Mary B., Scholz, Sonja W., Blauwendraat, Cornelis   +4 more
openaire   +3 more sources

Evaluation of the Efficacy of Photobiomodulation Therapy, Therapeutic Ultrasound, and Boric Acid in the Prevention of Intra‐Abdominal Adhesions in an Experimental Rat Model: A Macroscopic, Histopathological, and Gene Expression Analysis

Lasers in Surgery and Medicine, EarlyView.
ABSTRACT Objectives This study aimed to evaluate the efficacy of photobiomodulation therapy (PBMT), therapeutic ultrasound (TUS), boric acid (BA), and their combinations in preventing experimentally induced intra‐abdominal adhesions in rats. Materials and Methods Ninety‐six male Wistar rats (14 weeks old) were randomly assigned to eight groups (Control,
Sıtkıcan Okur, Büşra Baykal, Latif Emrah Yanmaz, Ayşe Gölgeli Bedir, Damla Tuğçe Okur, Mümin Gökhan Şenocak, Ferda Turgut, Serkan Yildirim, İsmail Bolat, Betül Apaydin Yildirim, Özlem Özdemir Tozlu   +10 more
wiley   +1 more source