Results 21 to 30 of about 17,871 (218)

Production Logistics in Industry 3.X: Bibliometric Analysis, Frontier Case Study, and Future Directions

Systems, 2023
At present, the development of the global manufacturing industry is still in the transition stage from Industry 3.0 to Industry 4.0 (i.e., Industry 3.X), and the production logistics system is becoming more and more complex due to the individualization ...
Honglin Yi, Ting Qu, Kai Zhang, Mingxing Li, George Q. Huang, Zefeng Chen   +5 more
doaj   +1 more source

Unraveling neurotransmitter changes in de novo GBA-related and idiopathic Parkinson's disease

Neurobiology of Disease, 2023
Background: Presently, neurotransmitter deficits in GBA-related Parkinson's disease (GBA-PD) and relationships with cognitive impairment are poorly understood.
Jingru Ren, Lei Yan, Hao Zhou, Chenxi Pan, Chen Xue, Jun Wu, Weiguo Liu   +6 more
doaj   +1 more source

Targeted delivery of galbanic acid to colon cancer cells by PLGA nanoparticles incorporated into human mesenchymal stem cells [PDF]

Avicenna Journal of Phytomedicine, 2022
Objective: The aim of this study was to investigate the efficacy of mesenchyme stem cells (MSCs) derived from human adipose tissue (hMSCs) as carriers for delivery of galbanic acid (GBA), a potential anticancer agent, loaded into poly (lactic-co-glycolic
Mahboubeh Ebrahimian, Sanaz Shahgordi, Rezvan Yazdian-Robati, Leila Etemad, Maryam Hashemi, Zahra Salmasi   +5 more
doaj   +1 more source

Gene-wise association of variants in four lysosomal storage disorder genes in neuropathologically confirmed Lewy body disease. [PDF]

PLoS ONE, 2015
Variants in GBA are associated with Lewy Body (LB) pathology. We investigated whether variants in other lysosomal storage disorder (LSD) genes also contribute to disease pathogenesis.We performed a genetic analysis of four LSD genes including GBA, HEXA ...
Lorraine N Clark, Robin Chan, Rong Cheng, Xinmin Liu, Naeun Park, Nancy Parmalee, Sergey Kisselev, Etty Cortes, Paola A Torres, Gregory M Pastores, Jean P Vonsattel, Roy Alcalay, Karen Marder, Lawrence L Honig, Stanley Fahn, Richard Mayeux, Michael Shelanski, Gilbert Di Paolo, Joseph H Lee   +18 more
doaj   +1 more source

The Impact of Maternal Gut Microbiota during Pregnancy on Fetal Gut–Brain Axis Development and Life-Long Health Outcomes

Microorganisms, 2023
Gut microbiota plays a critical role in physiological regulation throughout life and is specifically modified to meet the demands of individual life stages and during pregnancy.
Elizabeth M. Sajdel-Sulkowska
doaj   +1 more source

Vapor‐Phase Grain‐Boundary Anchoring Enables Molecular Toughening and Record Bending Endurance in Pilot‐Scale Roll‐to‐Roll‐Printed Flexible Perovskite Modules

Angewandte Chemie, EarlyView.
A vapor‐phase molecular toughening strategy is developed for pilot‐scale roll‐to‐roll (R2R) ‐compatible fabrication of flexible perovskite solar modules. Thiol vapor selectively regulates crystallization and anchors at grain boundaries, reducing defects while enhancing mechanical resilience.
Lirong Dong, Viktor Rehm, Shudi Qiu, Zexian Han, Naveen Harindu Hemasiri, Michael Wurmshuber, Michael Wagner, Cindy‐Ly Tavera‐Méndez, Dorothea Wisser, Chaohui Li, Robin Basu, Leopold Lahn, Olga Kasian, Sarmad Feroze, Wolfgang Heiss, Andreas Distler, Hans‐Joachim Egelhaaf, Fu Yang, Christoph J. Brabec   +18 more
wiley   +2 more sources

Detection of Microbial Growth on Indoor Building Materials in Two Countries Using qPCR

Microorganisms
According to several reports, 10–50% of buildings in Europe and worldwide suffer from moisture problems, which can lead to microbial growth in building materials. Unrepaired moisture and microbial damage can lead to the degradation of building structures
Helena Rintala, Oliver Röhl, Pinja Tegelberg, Teija Meklin   +3 more
doaj   +1 more source

The link between the GBA gene and parkinsonism [PDF]

The Lancet Neurology, 2012
Mutations in the glucocerebrosidase (GBA) gene, which encodes the lysosomal enzyme that is deficient in Gaucher's disease, are important and common risk factors for Parkinson's disease and related disorders. This association was first recognised in the clinic, where parkinsonism was noted, albeit rarely, in patients with Gaucher's disease and more ...
Ellen, Sidransky, Grisel, Lopez
openaire   +2 more sources

Legal Approaches and Regulatory Methods for Fintech in the Guangdong – Hong Kong – Macao Greater Bay Area

Journal of Digital Technologies and Law
Objective: To look at the fintech regulatory policy and regulatory system in the Greater Bay Area through the lens of the Trilemma of Innovation doctrine in order to identify the applicability and extrapolation of existing legal models in the zone of ...
Y. Kuchina
doaj   +1 more source

Parkinson’s Clustering in Families of Non-Neuronopathic N370S Mutation Carriers Indicates the Presence of Genetic Modifiers

Journal of Parkinson’s Disease, 2021
Low penetrance of Parkinson’s disease (PD) associated with GBA pathogenic variants indicates the presence of modifiers genes. Clusters of PD cases in certain families with GBA variants would serve as a strong evidence for the clinical relevance of such ...
Tama Dinur, Michal Becker-Cohen, Shoshana Revel-Vilk, Ari Zimran, David Arkadir   +4 more
doaj   +1 more source