Results 151 to 159 of about 2,830 (159)
Some of the next articles are maybe not open access.
Lessons and future directions for GBA1-targeting therapies
The Lancet Neurology, 2023openaire +2 more sources
Mechanisms of GBA1 related PD in hiPSC derived neurons
2018Parkinson's Disease (PD) is the second most common neurodegenerative disorder after Alzheimers Disease affecting approximately 5% of the population over 80 years of age. The exact mechanisms underlying the disease are not known but environmental as well as genetic factors have been described to contribute to the disease progression.
openaire +1 more source
Helicobacter pylori induces GBA1 demethylation to inhibit ferroptosis in gastric cancer
Molecular and Cellular BiochemistryThis research investigates potential therapeutic targets for gastric cancer, focusing on ferroptosis-related genes. Gastric cancer is known for its lower survival rates, necessitating new treatment strategies. This study employed Mendelian randomization to identify ferroptosis-related genes and methylation sites in gastric cancer, examining ...
Chenjie, Shen +6 more
openaire +2 more sources
Venglustat in GBA1-related Parkinson's disease
The Lancet NeurologyAri, Zimran +4 more
openaire +2 more sources
Venglustat in GBA1-related Parkinson's disease – Authors' reply
The Lancet NeurologyS Pablo Sardi +13 more
openaire +2 more sources
This thesis investigates the GBA1 gene, which encodes Glucocerebrosidase (GCase), a lysosomal enzyme critical for glucosylceramide and cholesterol metabolism. Over 300 pathogenic mutations have been identified, including L444P and N370S, which, in homozygous or compound heterozygous forms, cause Gaucher disease.
openaire +1 more source
openaire +1 more source
Epigenomic profile of GBA1 in Parkinson's disease
Parkinsonism & Related DisordersEloise Berson +16 more
openaire +1 more source
Glucocerebrosidase Enzyme Activity in GBA1 Mutation Parkinson Disease (P4.042)
Neurology, 2014Robert Ortega +12 more
openaire +1 more source