Results 131 to 140 of about 3,043 (176)

Parkinson's disease and Gaucher disease : focus on the GBA1 link

Parkinson’s disease (PD) is the 2nd most common neurodegenerative disorder in the world, characterized by both motor as well as many non-motor features. There are many symptomatic treatments available, that may shift significantly during the course of the disease.
openaire   +1 more source

RETRACTED: A systematic genomic screen of 755 early-onset Parkinson’s patients from the 100,000 Genomes Project increases diagnostic yield and directs clinical pathways

Newbury DF, Sabu N, Hussein ESH, Taylor JC.   +3 more
europepmc   +1 more source

Dairy-rich diet triggers hepatic α-synuclein pathology via the liver-brain axis in GBA1-related Parkinson's disease. [PDF]

NPJ Parkinsons Dis
Chen Y, Ma M, Zhang R, Guo C, Ding X, Wang J, Qin C, Feng R, Meng H, Wu H, Que W, Wang X, Tang B.   +12 more
europepmc   +1 more source

The c-Abl-RIPK3 Axis Drives Mitochondrial Dysfunction and Impaired Mitophagy in Gaucher Disease Models. [PDF]

Antioxidants (Basel)
Lamaizon CM, Tironi-Hernández R, Arévalo NB, Ahumada SD, Gutiérrez DA, Brito-Fernández L, Del Campo A, Zanlungo S, Álvarez AR.   +8 more
europepmc   +1 more source

LRRK2 kinase mediates increased GCase activity in microglia in response to IFNγ-induced proinflammatory stimulation. [PDF]

NPJ Parkinsons Dis
MacDougall EJ, Chen CX, Deneault E, You Z, Kalaydjian D, Abdian N, Durcan TM, Senkevich K, Gan-Or Z, Fon EA.   +9 more
europepmc   +1 more source

Interferon gamma stimulates coordinated changes in LRRK2, GCase, and cathepsin activities in idiopathic and genetic Parkinson's disease monocytes. [PDF]

NPJ Parkinsons Dis
Hughes LP, Wallings RL, Agin-Liebes J, Alcalay RN, Garrido A, Tansey MG, Dzamko N.   +6 more
europepmc   +1 more source

A guide to selecting high-performing antibodies for GCase (UniProt ID: P04062) for use in western blot, immunoprecipitation, and immunofluorescence. [PDF]

F1000Res
Worrall D, Alende C, Fothouhi M, Moleón VR, Bolívar SG, Ayoubi R, Francis V, Laflamme C, McPherson PS.   +8 more
europepmc   +1 more source

A novel peptide-based strategy to enhance GBA1 expression for treating Parkinson's disease. [PDF]

NPJ Parkinsons Dis
Kim H, Na J, Ryu HG, Lee E, Park H, Park H, Nam Y, Jeong GH, Pyo IH, Choi JH, Nah J, Jang SM, Song JH, Cho SJ, Kim S.   +14 more
europepmc   +1 more source

Diagnosis and follow-up of the first case of Gaucher disease under enzyme replacement therapy in Senegal. [PDF]

Ghana Med J
Keita M, Faye BF, Senghor AB, Diallo AB, Bousso ES, Touré SA, Seck M, Diop S.   +7 more
europepmc   +1 more source