Results 151 to 160 of about 4,639 (191)

Associations of Monocyte Glucocerebrosidase with Cognition and Cholinergic Innervation in GBA1 Parkinson's Disease. [PDF]

Mov Disord
Slingerland S, van der Zee S, van Ijzendoorn SCD, Slomp AC, Boertien JM, Meles SK, Kol A, Geerlings M, van Laar T.   +8 more
europepmc   +1 more source

Global research synergy: Advancing fundamental Parkinson's research through international collaboration. [PDF]

J Parkinsons Dis
Gutierrez-Arratia J, Saffie-Awad P, Schuh AF, Cornejo-Olivas M.   +3 more
europepmc   +1 more source

A human GBA-L444P transgene drives early and persistent dopamine neurotransmission deficits and alpha-synuclein pathology in a mouse model of early Parkinson’s disease

Connor-Robson N, Diviney T, Alegre-Abarrategui J, Roberts B, Brimblecombe KR, Bengoa-Vergniory N, Waters H, Cioroch M, Davies B, Bila KO, van der Lienden MJC, Aerts JMFG, Cragg S, Wade-Martins R.   +13 more
europepmc   +1 more source

GBA1-Associated Parkinson’s Disease Is a Distinct Entity

International Journal of Molecular Sciences
GBA1-associated Parkinson’s disease (GBA1-PD) is increasingly recognized as a distinct entity within the spectrum of parkinsonian disorders. This review explores the unique pathophysiological features, clinical progression, and genetic underpinnings that differentiate GBA1-PD from idiopathic Parkinson’s disease (iPD).
Per Svenningsson, Shoshana Revel-Vilk, Jan Lukas   +2 more
exaly   +4 more sources

Secretome Analyses Identify FKBP4 as a GBA1-Associated Protein in CSF and iPS Cells from Parkinson’s Disease Patients with GBA1 Mutations

International Journal of Molecular Sciences
Mutations in the GBA1 gene increase the risk of developing Parkinson’s disease (PD). However, most carriers of GBA1 mutations do not develop PD throughout their lives. The mechanisms of how GBA1 mutations contribute to PD pathogenesis remain unclear. Cerebrospinal fluid (CSF) is used for detecting pathological conditions of diseases, providing insights
Per Svenningsson, Rika Kojima, Xiaoqun Zhang   +2 more
exaly   +5 more sources

A Global Perspective of GBA1-Related Parkinson’s Disease: A Narrative Review

Genes
Parkinson’s disease (PD) is considered to be the second most prominent neurodegenerative disease and has a global prevalence. Glucocerebrosidase (GBA1) gene mutations represent a significant hereditary risk factor for the development of PD and have a profound impact on the motor and cognitive progression of the disease.
Christos Koros, Ioanna Pachi, Nikolaos Papagiannakis   +2 more
exaly   +5 more sources

Some of the next articles are maybe not open access.

Related searches:

Classification of GBA1 variants in Parkinson’s disease; the GBA1 -PD browser

Movement Disorders, 2022
ABSTRACT Background GBA1 variants are among the most common genetic risk factors for Parkinson’s Disease (PD). GBA1 variants can be classified into three categories based on their role in Gaucher’s Disease (GD) or PD ...
Sitki Cem Parlar, Francis P. Grenn, Jonggeol Jeffrey Kim, Cornelis Baluwendraat, Ziv Gan‐Or   +4 more
openaire   +2 more sources