Results 41 to 50 of about 33,428 (267)

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Case report: Lyme disease presenting as Guillain-Barré syndrome in Jeddah, Saudi Arabia

Journal of Family Medicine and Primary Care
Lyme disease (LD) is the most common vector-borne disease in the United States; however, it is very rare in Saudi Arabia. If left untreated, the disease can lead to neuroborreliosis, which can rarely present as Guillain-Barré-like syndrome.
Heba Abbas Ezmeirlly
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Diagnostic Challenges and Genotypic Characteristics of CAMP-negative Phenotype GBS Isolates

Journal of Pure and Applied Microbiology
Streptococcus agalactiae (group B Streptococcus, GBS) is a pathogen associated with severe diseases in newborn and immunocompromised patients. One of the commonly used approaches for GBS identification is the CAMP test. It represents enhance of hemolysis
Vasil S. Boyanov, Alexandra S. Alexandrova, Raina T. Gergova   +2 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Developing syndrome of inappropriate antidiuretic hormone secretion in Guillain-Barre syndrome

Open Health
Guillain-Barre Syndrome (GBS) is associated with weakness of limbs along with pain and numbness of the affected limbs. There may develop other features in GBS patients as well, especially in those who are ventilated, such as paralysis of respiratory and ...
Tajwar Sakib
doaj   +1 more source

Exploring the Role of Nuclear Factor Kappa B in the Immunobiology of Inflammatory Neuropathies

Annals of Indian Academy of Neurology
Background and Objectives: Guillain-Barré syndrome (GBS) and chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) are inflammatory conditions, representing prototype examples of immune-mediated disorders of the peripheral nervous system ...
Madhu Nagappa, Sandipan Mondal, B Pradeepkumar, Thrinath Mullapudi, Srinath Rajeevan, Pokala Akhil, Lakshminarayanapuram Gopal Viswanathan, Monojit Debnath   +7 more
doaj   +1 more source

On discrete GB-splines

ANZIAM Journal, 2000
Summary: Explicit formulae and recurrence relations are obtained for discrete generalized B-splines (discrete GB-splines for short). Properties of discrete GB-splines and their series are studied. It is shown that the series of discrete GB-splines is a variation diminishing function and the systems of discrete GB-splines are weak Chebyshev systems.
openaire   +3 more sources