Results 21 to 30 of about 609,142 (192)
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
Simultaneous RP-HPLC determination of sparfloxacin and dexamethasone in pharmaceutical formulations
Brazilian Journal of Pharmaceutical Sciences, 2013 The present study describes the development and subsequent validation of simple and accurate stability indicating RP-HPLC method for the determination of sparfloxacin and dexamethasone in pharmaceutical formulations in the presence of their stress ...
Syed Naeem Razzaq +4 more
doaj +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Taylor–Couette flow of a fractional second grade fluid in an annulus due to a time-dependent couple
Nonlinear Analysis, 2011 Exact solutions for the velocity field and the associated shear stress, corresponding to the flow of a fractional second grade fluid between two infinite coaxial cylinders, are determined by means of Laplace and finite Hankel transforms.
M. Imran +3 more
doaj
Contributory Factors of Traffic Accidents in Lahore Using Generalized Linear Models (GLM)
NUST Journal of Engineering Sciences, 2019 The geometric design of roads is the branch of highway engineering concerned with the positioning of the physical elements of the roadway according to standards and limitations with objectives to optimize efficiency and safety while minimizing cost and ...
Hajra Slam, Yasar Mahmood
doaj +1 more source
Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source
Thematic and Comparative Analysis of Rubaiyats of Muhammad Ismail Roshan
مجلہ تحقیق, 2020 Muhammad Ismail Roshan was a Sufi and Prominent Persian Poetof 19th century. He was born in Sindh. He was a man of generosityand piety. He took active part in politics as well as in religiousservices and was an active member of Khilafah movement.
Aqsa Sajid, Rizwana Khaliq
doaj +1 more source
Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source