Results 41 to 50 of about 609,142 (192)
Evolution‐guided yeast complementation reveals functional differences in human PSPH variants
FEBS Open Bio, EarlyView.Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez +6 more
wiley +1 more source
FEBS Open Bio, EarlyView.The brown marmorated stink bug, Halyomorpha halys, mainly secretes 4‐oxo‐(E)‐2‐hexenal, (E)‐2‐decenal, dodecane and tridecane, a mixture representative of that released by many heteropterans. We demonstrated that H. halys can synthesise these secretory components de novo using dietary glucose.
Haruna Fujimori, Koji Noge
wiley +1 more source
Dual native G‐quadruplex folding is associated with chromatin looping at the MYC locus
FEBS Open Bio, EarlyView.BG4‐detectable G‐quadruplex (G4) in HaCaT and NHEK keratinocytes identified folded and unfolded G4s enriched at promoters/TSSs and active enhancers, whereas unfolded G4s also overlapped weak/poised enhancers. At MYC–PVT1, 3C‐qPCR detected enhancer–promoter looping only when G4s were simultaneously folded at both regulatory elements under native ...
Dieila Giomo de Lima +7 more
wiley +1 more source
Cell surface CD11c as a neutrophil aging marker molecule
FEBS Open Bio, EarlyView.Cell surface CD11chi neutrophils were more aged and had better phagocytic function than CD11c−/lo neutrophils. Transcriptomic analysis of CD11chi neutrophils and CD11c−/lo neutrophils in pediatric population showed that the most difference was seen in infants.
Sophia Koutsogiannaki +5 more
wiley +1 more source
BMC Endocrine DisordersBackground Parathyroid hormone (PTH) plays a pivotal role in calcium–phosphate metabolism and bone health; however, interpretation of PTH concentrations remains challenging because of biological variability and substantial analytical heterogeneity among ...
Rihwa Choi, Sung-Eun Cho, Sang Gon Lee
doaj +1 more source
English-Hindustani Dictionary of Dr. Gilchrist
مجلہ تحقیق, 2020 Language is an expression of socio-political activity of any strata.Knowledge of the local language is an essential ingredient of aneffective participation in the political activity. Therefore, theshifting of the East India Company’s interests from
Zaheer Hasan Watto, Shabnam Ishaq
doaj +1 more source
Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level
Aging and Cancer, EarlyView.This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley +1 more source
BMC Endocrine DisordersBackground Monitoring test utilization is a key component of improving the quality of clinical laboratory testing. In diabetes management, glycated hemoglobin (hemoglobin A1c, HbA1c) reflects long-term glycemic control in addition to blood glucose levels;
Rihwa Choi, Mi-Jung Park, Sang Gon Lee
doaj +1 more source
Five‐Year Disease Progression in Synuclein Seeding Positive Sporadic Parkinson's Disease
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To provide a comprehensive description of disease progression in synuclein seeding assay (SAA) positive sporadic Parkinson Disease participants, using Neuronal Synuclein Disease integrated biological and functional impairment staging framework.
Paulina Gonzalez‐Latapi +19 more
wiley +1 more source
International Journal of Distance Education and E-Learning, 2018 Present research focused to know the role of public sector universities in promoting higher education through distance education in Punjab, Pakistan was conducted to evaluate the support services like reading material, teaching faculty, study Centre ...
Ms. Nadia, Naeem Mohsin
doaj +1 more source