Results 51 to 60 of about 584,413 (194)
Complementarity of Long‐Reads and Optical Mapping in Parkinson's Disease for Structural Variants
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Long‐read sequencing and optical genome mapping technologies have the ability to detect large and complex structural variants. This has led to the discovery of novel pathogenic variants in neurodegenerative movement disorders. Thus, we aimed to systematically compare the SV detection capabilities of OGM and ONT in Parkinson's disease.
André Fienemann +17 more
wiley +1 more source
Multidimensional Profiling of MRI‐Negative Temporal Lobe Epilepsy Uncovers Distinct Phenotypes
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Although hippocampal sclerosis (TLE‐HS) represents the most frequent cause of temporal lobe epilepsy (TLE), up to 30% of patients show no lesion on visual MRI inspection (TLE‐MRIneg). These cases pose diagnostic and therapeutic challenges and are underrepresented in surgical series.
Alice Ballerini +28 more
wiley +1 more source
Grade Inflation and Human Capital Accumulation among Pakistani University Students
Journal of Accounting and Finance in Emerging Economies, 2020 The central objective of current study was exploring the level of school acquired human capital. To understand the human capital and grade inflation, 2 Focus Group Discussions (FGDs) were conducted.
Anwar Ul Haq +3 more
doaj
On some rotational flows of non-integer order rate type fluids with shear stress on the boundary
Ain Shams Engineering Journal, 2018 This article presents rotational flows of some rate type fluids with non-integer order derivatives. The fluid fills an infinite straight circular cylinder and its motion is generated by a time dependent torsion, applied to the surface of the cylinder. As
Azhar Ali Zafar +2 more
doaj +1 more source
Location‐Specific Hematoma Volume Predicts Early Neurological Deterioration in Supratentorial ICH
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Early neurological deterioration (END) adversely affects outcomes in patients with intracerebral hemorrhage (ICH). This study aimed to determine the location‐specific hematoma volumes for END in supratentorial ICH patients. Methods We retrospectively analyzed supratentorial ICH patients presenting from two prospective cohorts.
Zuoqiao Li +10 more
wiley +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Onasemnogene abeparvovec (OA) is an AAV9‐based gene therapy for spinal muscular atrophy type I (SMA I). Real‐world outcomes show increased response variability compared to clinical trials, and follow‐up data beyond 12–18 months are limited.
Marika Pane +43 more
wiley +1 more source
Cracking the Code: Genotype–Phenotype Correlation Models in Sarcoglycanopathies
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Sarcoglycanopathies are among the most severe limb‐girdle muscular dystrophies (LGMD), though milder presentations have been described. These diseases are primarily caused by missense variants, but the limited predictability of their effect on protein maturation, complex formation, and transport has hindered reliable genotype ...
Leonela Luce +72 more
wiley +1 more source
Discover SustainabilityCopper oxide nanoparticles (CuO NPs) are emerging as promising multifunctional agents for agriculture and environmental remediation. Here, we report the laboratory-scale synthesis of sodium dodecyl sulfate (SDS)-stabilized CuO NPs via a co-precipitation ...
Iqra Ramzan +10 more
doaj +1 more source
Multiple Sclerosis Relapse Activity After Ozanimod Discontinuation in DAYBREAK Trial Participants
Annals of Clinical and Translational Neurology, EarlyView.Multiple Sclerosis Relapse Activity After Ozanimod Discontinuation in DAYBREAK Trial Participants. ABSTRACT Objective Return of disease activity is expected when patients discontinue disease‐modifying therapy (DMT) for multiple sclerosis (MS). Some MS DMTs are associated with higher‐than‐expected disease activity (rebound) after discontinuation.
Ralf Gold +12 more
wiley +1 more source
CleanSeqU algorithm for decontamination of catheterized urine 16S rRNA sequencing data
Scientific ReportsContamination in low-biomass samples, such as urine, presents a major challenge for 16S rRNA gene sequencing, as extraneous DNA from reagents and the environment often obscures microbial signals.
Sung Min Yoon +2 more
doaj +1 more source