Results 221 to 230 of about 440,371 (252)

GC-MS-based metabolome classification of sturgeon caviar and fish roe samples reveals unique caviar signatures, interspecies and gender variabilities. [PDF]

Sci Rep
Ibrahim N, Khattab AR, Mohammad AS, Al-Hammady MA, Ayoub IM, Farag MA.   +5 more
europepmc   +1 more source

Single‐Cell Atlas of Subchondral Bone Marrow Lesions Reveals Proteostasis Dysfunction as a Druggable Mechanism for Early Osteoarthritis

Advanced Science, EarlyView.
This study reveals that abnormal mechanical stress downregulates the expression of HSP70 and impairs proteasome function in osteoarthritic bone cells, leading to misfolded collagen I accumulation and ER stress. When intracellular proteostasis capacity is exceeded, USP19 mediates the secretion of misfolded proteins into the extracellular space ...
Hailun Xu, Ting He, Yu Qian, Jia Li, Bowei Ni, Xiaojie Xu, Huanbo Wang, Peng Wang, Guoqing Cao, Siqi Ying, Guangyu Ding, Rong Wang, Zenghui Gu, Wei Li, Zhentao Man, Houfeng Zheng, Zhaohua Zhu, Zhen Li, Qingjun Meng, Chao Zheng, Liu Yang   +20 more
wiley   +1 more source

GC-MS based bioactive profiling of Phyllanthus niruri and its antibacterial potential through experimental and computational studies. [PDF]

PLoS One
Labu ZK, Karim S, Afroz M, Batul UK, Akther L, Rahman MT, Arifuzzaman S.   +6 more
europepmc   +1 more source

Conversion of Transplanted Mature Hepatocytes into Afp+ Reprogrammed Cells for Liver Regeneration After Injury

Advanced Science, EarlyView.
Donor‐derived tdTomato+ mature hepatocytes were FACS‐isolated and transplanted into Fah−/− host mice. During regeneration, these cells convert into proliferative, unipotent Afp+ rHeps. Their plasticity is governed by a PPARγ/AFP‐dependent metabolic switch, segregating into pro‐proliferative Afplow and pro‐survival Afphigh subpopulations.
Ting Fang, Chao Yang, Hua Qiu, Yuan Du, Xicheng Wang, Yuting Li, Mingyang Xu, Changcheng Liu, Xiuhua Li, Na Guo, Jun Shi, Wencheng Zhang, Zhiying He   +12 more
wiley   +1 more source

Metabolomic profiling of sweat VOCs for occupational stress surveillance in firefighters: a GC-MS pilot study. [PDF]

J Occup Med Toxicol
Somphot T, Sirithaweesuk T, Dubas L, Tungkijanansin N, Tunvirachaisakul C, Maes M, Sirinara P, Kulsing C.   +7 more
europepmc   +1 more source

Overcoming the Trade‐Off Between Magnetic Coupling and Electrical Insulation in Soft Magnetic Materials via Nanochain Engineering

Advanced Science, EarlyView.
This study employs a nanochain engineering approach combined with an in situ oxidation strategy to fabricate self‐insulating iron‐based magnetic nanochains, addressing the challenge of balancing magnetic coupling and electrical insulation in soft magnetic materials.
Dingrong Zuo, Lichen Liu, Haibo Ke, Rongsheng Bai, Huaping Ding, Jing Zhou, Zhenxiang Cheng, Peng Yu, Weihua Wang   +8 more
wiley   +1 more source

BAGI-assessed green GC-MS method for rapid analysis of paracetamol/metoclopramide in pharmaceuticals and plasma. [PDF]

Sci Rep
Al-Khateeb LA, Gamal M, Elsayed MA, Löbenberg R, Hegazy AM.   +4 more
europepmc   +1 more source

Respiratory‐Limbic Coupling via a Thalamic Circuit Alleviates Anxiety

Advanced Science, EarlyView.
This study delineates a conserved preBötCGlu→PVT→CeA circuit that gates anxiety and respiration. Activation of this circuit is anxiolytic and respiratory‐stabilizing, while its inhibition has the opposite effect. Mechanistically, PVT exerts its anxiolytic action via a disinhibitory microcircuit: its inputs preferentially target CeL GABAergic neurons ...
Shangyu Bi, Xiaoyi Wang, Huichun Luo, Ziteng Yue, Tianjiao Deng, Yuhang Liu, Xinxin Chen, Jianxu Zhao, Luo Shi, Ning Ma, Lingyan Mao, Jing Ding, Jiwen Xu, Ti‐Fei Yuan, Sheng Wang, Fang Yuan   +15 more
wiley   +1 more source

Organic geochemical evidence for life in Archean rocks identified by pyrolysis-GC-MS and supervised machine learning. [PDF]

Proc Natl Acad Sci U S A
Wong ML, Prabhu A, Alexander CO, Cleaves HJ, Cody GD, Hystad G, Bermanec M, Bleeker W, Boyce CK, Corpolongo A, Czaja AD, Das S, Gaines RR, Gregory DD, Jaszczak JA, Javaux EJ, Jodder J, Knoll AH, Van Kranendonk M, Maloney KM, Noffke N, Rainbird R, Slaughter E, Stüeken EE, Summons RE, Westall F, Wiemann J, Xiao S, Hazen RM.   +28 more
europepmc   +1 more source