Results 41 to 50 of about 439,764 (310)

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Application of direct bioautography and SPME-GC-MS for the study of antibacterial chamomile ingredients [PDF]

, 2012
The isolation and characterization of antibacterial chamomile components were performed by the use of direct bioautography and solid phase microextraction (SPME)-GC-MS.
Adams R.P., Afek U., Aggag M.E., Al-Ismail K.M., Arias Abrodo P., Arthur C.L., Berry M., Bisset N.G., Botz L., Choma I.M., Cinco M., Daniel M., Dóra Kertesy, Eloff J.N., Ernő Tyihák, Iordache A., Lis-Balchin M., Lord H., McKay D.L., Mincsovics E., Mincsovics E., Mincsovics E., Móricz M., Móricz M., Móricz M., Ojala T., Péter Ott, Repcák M., Riu-Aumatell M., Soliman K.M., Srivastava J.K., Szabolcs Szarka, Szőke, Szőke, Szőke, Tyihák E., Tyihák E., Weins C., Ágnes Móricz, Éva Héthelyi, Éva Szőke   +40 more
core   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

In-Depth Investigation of the Chemical Profile of Pelargonium odoratissimum (L.) L’Hér. Hydrolate by SPME-GC/MS, GC/MS, LVI-GC/MS and PTR-Tof-MS Techniques

Chemosensors
Hydrolates are aromatic aqueous solutions saturated with volatile water-soluble compounds of essential oil. Despite their potential, hydrolates remain less explored than essential oils. In this work, the hydrolate of Pelargonium odoratissimum (L.) L’Hér.
Cosimo Taiti, Vittorio Vinciguerra, Monica Mollica Graziano, Elisa Masi, Stefania Garzoli   +4 more
doaj   +1 more source

Determination of Endosulfan Concentrations in Biological Samples by GC-MS/MS [PDF]

Fayixue Zazhi, 2018
Objective To establish an analytical method of the endosulfan concentrations （α-endosulfan and β-endosulfan） in biological samples by GC-MS/MS. To observe the distribution of endosulfan in aquatic animals and provide experimental evidence for forensic ...
ZHANG Fan, QIAO Jun-yuan, YU Ming-jun，et al .
doaj   +1 more source

Characterization of the Volatile Compounds of Zhenba Bacon at Different Process Stages Using GC–MS and GC–IMS

Foods, 2021
Zhenba bacon (ZB), a type of Chinese traditional bacon with a long history, has attracted considerable attention in the Southwest of China for its unique flavor.
Linjie Xi, Jing Zhang, Ruixiao Wu, Tian Wang, Wu Ding   +4 more
doaj   +1 more source

Assessment of Polycyclic Aromatic Hydrocarbon Contamination of Breeding Pools Utilized by the Puerto Rican Crested Toad, Peltophryne lemur. [PDF]

, 2012
Habitat preservation and management may play an important role in the conservation of the Puerto Rican crested toad, Peltophryne lemur, due to this species' small geographic range and declining native wild population. Bioavailable water concentrations of
De Voe, Ryan, Gjeltema, Jenessa, Shea, Damian, Stoskopf, Michael   +3 more
core   +3 more sources

Hands‐on protocol for preparing water‐soluble fractions from agri‐food samples for NMR‐based metabolomics analysis

FEBS Open Bio, EarlyView.
This research protocol outlines a workflow for nuclear magnetic resonance (NMR)‐based metabolomics in the agri‐food sector. Using two case studies—strawberry leaves (solid matrix) and wine (liquid matrix)—it details the procedures for sample preparation, data acquisition, and processing.
Andrea Fernández‐Veloso, Jaime Hiniesta‐Valero, Alejandra Guerra‐Castellano, Miguel A. De la Rosa, Irene Díaz‐Moreno   +4 more
wiley   +1 more source

An application of data mining to fruit and vegetable sample identification using Gas Chromatography-Mass Spectrometry [PDF]

, 2012
One of the uses of Gas Chromatography-Mass Spectrometry (GC-MS) is in the detection of pesticide residues in fruit and vegetables. In a high throughput laboratory there is the potential for sample swaps or mislabelling, as once a sample has been pre ...
Fletcher, Dale, Holmes, Geoffrey, Reutemann, Peter   +2 more
core