Results 41 to 50 of about 1,425,145 (305)

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

GC/GC-MS analysis and biological activities of Lantana Camara Linn.

Journal of Sustainable Environment
Medicinal plants have been a part of human history for thousands of years and are still used as healthcare throughout the world. The current research aims to explore the chemical constituents of the methanol soluble extract (LC-Me) and petroleum ether ...
Riffat Abdul Ghafoor, Anjum Ayub, Syed Nawazish Ali, Aneela Wahab, Sabira Begum, Bina Shaheen Siddiqui, Saima Tauseef, Muhammad Tariq Rajput   +7 more
doaj   +1 more source

30th Anniversary of comprehensive two‐dimensional gas chromatography: Latest advances

Analytical Science Advances, 2021
In this review, we report on the latest (2020‐Early 2021) instrumental advances and applications of comprehensive two‐dimensional gas chromatography (GC×GC), including its hyphenation with novel upstream or downstream processes (sample preparation ...
Delphine Zanella, Jean‐François Focant, Flavio A. Franchina   +2 more
doaj   +1 more source

Discovery of the most isolated globular cluster in the local universe

, 2012
We report the discovery of two new globular clusters in the remote halos of M81 and M82 in the M81 Group based on Hubble Space Telescope archive images. They are brighter than typical globular clusters (MV = -9.34 mag for GC-1 and M_V = -10.51 mag for GC-
Chiboucas, Chynoweth, Cockcroft, Conn, Durrell, Gerke, Huxor, Hwang, Mayya, Mouhcine, Méndez, Nantais, Nantais, Nantais, Park, Peng, Santiago-Cortés, Santiago-Cortés, Schlegel, Slater, Stonkutė, Williams, York   +22 more
core   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

A VST and VISTA study of globular clusters in NGC253 [PDF]

, 2017
Aims. We analyze the properties of the sources in the NGC253 to define an up to date catalog of GC candidates in the galaxy. Methods. Our analysis is based on the science verification data of two ESO survey telescopes, VST and VISTA.
Arnaboldi, Magda, Cantiello, Michele, Capaccioli, Massimo, Grado, Aniello, Greggio, Laura, Iodice, Enrica, Limatola, Luca, Rejkuba, Marina   +7 more
core   +2 more sources

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Cyclodextrin-based nanocarriers as promising scaffolds for overcoming challenges of doxorubicin delivery in cancer chemotherapy

Carbohydrate Polymer Technologies and Applications
Pharmacotherapy, a cornerstone in cancer treatment, faces significant challenges due to the inherent water-insolubility of many potent anticancer drugs. Cyclodextrins (CDs) have emerged as a promising solution in the field of drug delivery.
Sara Payamifar, Amin Foroozandeh, Mehrab Pourmadadi, Majid Abdouss, Mohammad Hasanzadeh   +4 more
doaj   +1 more source

The Open Cluster Chemical Analysis and Mapping Survey: Local Galactic Metallicity Gradient with APOGEE using SDSS DR10 [PDF]

, 2013
The Open Cluster Chemical Analysis and Mapping (OCCAM) Survey aims to produce a comprehensive, uniform, infrared-based dataset for hundreds of open clusters, and constrain key Galactic dynamical and chemical parameters from this sample.
Allende Prieto, Carlos, Beers, Timothy C., Bizyaev, Dmitry, Brewington, Howard, Chojnowksi, S. Drew, Cunha, Katia, Ebelke, Garrett, Elia Garcia, Frinchaboy, Peter M., Hearty, Frederick R., Holtzman, Jon, Jackson, Kelly M., Johnson, Jennifer A., Kinemuchi, Karen, Majewski, Steven R., Malanushenko, Elena, Malanushenko, Viktor, Marchante, Moses, Meszaros, Szabolcs, Meyer, Brianne, Muna, Demitri, Nidever, David L., O'Connell, Julia, Oravetz, Daniel, Pan, Kaike, Perez, Ana, Schiavon, Ricardo P., Schneider, Donald P., Shetrone, Matthew, Simmons, Audrey, Smith, Verne V., Snedden, Stephanie, Thompson, Benjamin, Wilson, John C., Zasowski, Gail   +34 more
core   +2 more sources

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source