Results 41 to 50 of about 4,133 (246)
Neural Development, 2019 Background The cerebellum is a foliated posterior brain structure involved in coordination of motor movements and cognition. The cerebellum undergoes rapid growth postnataly due to Sonic Hedgehog (SHH) signaling-dependent proliferation of ATOH1+ granule ...
Alexandre Wojcinski +4 more
doaj +1 more source
Arthritis &Rheumatology, EarlyView.Objective Regeneration and expansion of Treg by low‐dose interleukin‐2 (IL‐2) therapy is considered a potential treatment strategy for a wide range of autoimmune diseases. To provide a pathophysiologically‐based rationale for low‐dose IL‐2 therapy, we investigated whether reversible defects in the Treg–IL‐2 axis emerge in inflammatory myopathies ...
Justus Ohmes +10 more
wiley +1 more source
British Journal of Clinical Pharmacology, EarlyView.Abstract Aims Canagliflozin was recently approved in type 2 diabetes mellitus (T2DM) patients ≥10 and <18 years old as a single agent dosed once daily (QD) or in a fixed‐dose combination with metformin dosed twice daily (BID). We characterize canagliflozin pharmacokinetics in paediatric patients with T2DM, compare estimated individual and simulated ...
Nele Goeyvaerts +6 more
wiley +1 more source
British Journal of Clinical Pharmacology, EarlyView.Aim The shortage of trained clinical assessors in African National Regulatory Authorities (NRAs) poses a challenge to effective regulatory decision‐making. Developed in line with the World Health Organization's (WHO) Global Competency Framework (WHO‐GCF), a university‐certified short course, Dossier assessment for clinical assessors in Africa, was ...
Stephanie Leigh +19 more
wiley +1 more source
Plant Methods, 2018 Background Guard cell protoplasts (GCPs) isolated from various plants have proven to be especially useful for studies of signal transduction pathways and plant development.
Xuehui Yao +5 more
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MULTI-SCALE MATCHING FOR THE AUTOMATIC LOCATION OF CONTROL POINTS IN LARGE SCALE AERIAL IMAGES USING TERRESTRIAL SCENES [PDF]
The International Archives of the Photogrammetry, Remote Sensing and Spatial Information Sciences, 2014 A technique to automatically locate Ground Control Points (GCPs) in large aerial images is presented considering the availability of low accuracy direct georeferencing data. The approach is based on image chips of GCPs extracted from vertical terrestrial
A. Berveglieri, A. M. G. Tommaselli
doaj +1 more source
Regulatory harmonization: Evolution, globalization and future directions
British Journal of Clinical Pharmacology, EarlyView.Regulatory harmonization has become an increasingly important and accepted approach to streamline regulatory review processes and expedite access to safe, effective and high‐quality medicines globally. This review explores the evolution and current status of regulatory harmonization, convergence and reliance initiatives.
Orin Chisholm +2 more
wiley +1 more source
Business Strategy and the Environment, EarlyView.ABSTRACT This study examines the influence of circular economy practices, as a manifestation of corporate social responsibility, on green value co‐creation and its subsequent effects on green collaborative practices and sustainable supply chain integration between providers and customers.
Adriana Santos +2 more
wiley +1 more source
Geocarto InternationalGridded climate products (GCPs) play a vital role in hydro-climatic modeling by overcoming the limitations of gauge data. This study compares the performance of the recently launched NASA POWER and ERA5-Land, with CHIRPS and APHRODITE, in simulating ...
Hongrong Du +3 more
doaj +1 more source
Accuracy Analysis of a Dam Model from Drone Surveys
Sensors, 2017 This paper investigates the accuracy of models obtained by drone surveys. To this end, this work analyzes how the placement of ground control points (GCPs) used to georeference the dense point cloud of a dam affects the resulting three-dimensional (3D ...
Elena Ridolfi +3 more
doaj +1 more source