Results 61 to 70 of about 7,195 (251)

Absorption, distribution, metabolism and excretion of londamocitinib after single‐dose inhaled, intravenous and oral administration in healthy participants

British Journal of Clinical Pharmacology, EarlyView.
Aim Londamocitinib (AZD4604) is an inhaled, selective Janus kinase 1 (JAK1) inhibitor in development for asthma. This open‐label, two‐part, phase I clinical study (NCT06157255) used a radiolabelled microtracer approach to evaluate the absolute bioavailability and the absorption, distribution, metabolism and excretion (ADME) of inhaled londamocitinib ...
Camille Riff, Peter Bold, Maria Heijer, Ryan A. Bragg, Danielle Steele, Tina Jellesmark Jensen, Davinder P. S. Dosanjh, Sabrina I. Hanswijk‐Bartelds, Esther van Duijn, Elwin R. Verheij, Somasekhara Menakuru, Rod Hughes, Helena Dahlbäck   +12 more
wiley   +1 more source

Factors Influencing Green Construction Practices in Context of COVID-19 Pandemic: Empirical Evidence from China

Buildings
Green construction practices (GCPs) are essential for the construction industry to achieve carbon neutral and sustainable development. However, the promotion of GCPs faces multifaceted challenges, particularly within the context of recent global ...
Chaofan Wang, Xiaojun Xie, Xinyi Chen, Chuanmin Shuai, Jing Shuai, Vladimir Strezov   +5 more
doaj   +1 more source

Deletion of Gli3 in mice causes abnormal frontal bone morphology and premature synostosis of the interfrontal suture

Frontiers in Physiology, 2012
Greig cephalopolysyndactyly syndrome (GCPS) is an autosomal dominant disorder with polydactyly and syndactyly of the limbs and a broad spectrum of craniofacial abnormalities.
Lotta eVeistinen, Maarit eTakatalo, Dörthe A. Kesper, Andrea eVortkamp, David P Rice, David P Rice   +5 more
doaj   +1 more source

Phase 1, open‐label, randomized study of the elecoglipron pharmacokinetic profile in healthy participants under fed and fasted conditions

British Journal of Clinical Pharmacology, EarlyView.
Aims Elecoglipron (AZD5004/ECC5004) is an oral small‐molecule glucagon‐like peptide‐1 receptor agonist (GLP‐1 RA) in development for weight management in people living with obesity or overweight and type 2 diabetes. This study aimed to characterize the pharmacokinetics (PK) profiles of two formulations of elecoglipron under fed and fasted conditions ...
Jianfeng Xu, Amina Haggag, Laurie Butcher, Haihui Liu, Wen Chen, Xuefeng Sun, Aruni Jha, Hongtao Yu, Anis Khan, Victoria E. R. Parker, Christer Tannergren, Xiaoliang Pan, Jianfeng Xu, Jingye Zhou   +13 more
wiley   +1 more source

Nanogel, a versatile nanoscopic platform for the simultaneous delivery of acyclovir and lignocaine for the treatment of Herpes simplex virus infection: formulation and characterizations

Nano Express
This study was designed to develop a nanogel formulation incorporating acyclovir and lignocaine (ALN). Various formulations were developed in which ALN-V (formulation-V) was optimized.
Adnan Aslam, Barkat A Khan, M Khalid Khan, Muhammad Bilal K Niazi   +3 more
doaj   +1 more source

mGFP-labeled, postmitotic migrating GCPs in the EGL with trailing and leading processes at P8.

, 2014
Left: P3-injected P8 cerebellum, mGFP  =  cells after recombination, mTomato  =  cells without recombination. Frames A-C are shown enlarged, A′-C′  =  further enlargement to show mGFP-immunoreactive GCPs in the inner EGL, A″-C″  =  mTomato. Arrowheads in
Thomas Günther (247952), Joachim Herz (28421), Petra May (581258), Roland Schüle (169570), Laura Steller (581257), Theresa Pohlkamp (581256), Michael Frotscher (226745), Hans H. Bock (447018)   +7 more
core   +1 more source

Safety and pharmacokinetics of inhaled aloxistatin: A first‐in‐human phase 1 dose escalation trial

British Journal of Clinical Pharmacology, EarlyView.
Aims Aloxistatin (E64d) is a membrane‐permeable cysteine protease inhibitor prodrug that is converted by esterases to the active metabolite E64c (loxistatin). This first‐in‐human study evaluated the safety, tolerability and pharmacokinetics of single ascending doses of inhaled E64d in healthy volunteers.
Sebastian Fähndrich, Franziska Friedrich, Daniel Soriano, Jona Gjeloshi, Björn C. Frye, Xuan Phuoc Nguyen, Lydia Herbstritt, Caroline von Spee‐Mayer, Britta Lang, Fabrice Nollevaux, Andreas Hoheisel, Dorothee Winterberg, Armin Braun, Thomas Epting, Christine Contini, Karl Winkler, Thomas Reinheckel, Franziska C. Trudzinski, Gernot Rohde, Daiana Stolz, Robert Bals, Martin J. Hug, Sebastian Wirtz, Christoph Peters, Carolin Jenkner   +24 more
wiley   +1 more source

Forest Height Extraction Using GF-7 Very High-Resolution Stereoscopic Imagery and Google Earth Multi-Temporal Historical Imagery

Journal of Remote Sensing
With the advent of very high-resolution (VHR) imaging satellites, it is possible to measure the heights of forest stands or even individual trees more accurately.
Wenjian Ni, Zijia Li, Qiang Wang, Zhiyu Zhang, Qingwang Liu, Yong Pang, Yating He, Zengyuan Li, Guoqing Sun   +8 more
doaj   +1 more source

Ground-Control Networks for Image Based Surface Reconstruction: An Investigation of Optimum Survey Designs Using UAV Derived Imagery and Structure-from-Motion Photogrammetry

Remote Sensing, 2016
The use of small UAV (Unmanned Aerial Vehicle) and Structure-from-Motion (SfM) with Multi-View Stereopsis (MVS) for acquiring survey datasets is now commonplace, however, aspects of the SfM-MVS workflow require further validation.
Toby N. Tonkin, Nicholas G. Midgley
doaj   +1 more source

Beyond antimicrobials: Ecological nano‐strategies for rebalancing dysbiotic oral microbial homeostasis

BMEMat, EarlyView.
Oral microbial homeostasis, a dynamic host‐microbe balance, is vital in infectious diseases. Conventional antibiotics often disrupt this homeostasis, spurring interest in nanomaterials for oral microbial homeostasis rebalancing. This review outlines nanomaterial strategies across three ecological levels (population/community, ecosystem, and cross ...
Chen Hu, Aohan Luan, Yujun Yang, Linlin Wang, Huilin Wang, Ning Wang, Guixin He, Yajie Yang, Rabiya Noor, Jawad Hussain, Longquan Shao   +10 more
wiley   +1 more source