Results 201 to 210 of about 3,285,010 (339)

Optimization of Crude Polysaccharide Extraction and Purification from the Black Outer Layer of the <i>Inonotus obliquus</i> Sterile Conk and Evaluation of the Purified Polysaccharide's In Vitro Antioxidant Activity, Inhibitory Effects on Tumor Cell Viability, and Immunomodulatory Activity. [PDF]

Foods
Ding M, Su Y, Zhang R, Liu H, Liu Y, Wang Q.   +5 more
europepmc   +1 more source

Bipolar Palladium Membrane Enabling Crossover‐Free Selective Proton Transport

Advanced Science, EarlyView.
This study introduces a crossover‐free bipolar palladium membrane that transports protons selectively via reversible Pd/PdHx absorption–desorption and lattice hydrogen diffusion, overcoming the conductivity–selectivity trade‐off of polymer membranes. It enables water‐fed Li‐mediated ammonia synthesis, achieving 51% Faradaic efficiency and stable 12 h ...
Jiyeon Baek, Yeongbae Jeon, Seunga Lee, Ahee Choi, Joonmok Shim, Kyungho Lee, Ho Woun Jung, Sun Hyung Kim, Churl Hee Cho, Hyung Chul Yoon, Yun Jeong Hwang, Jae Hyung Kim   +11 more
wiley   +1 more source

Iso- and Benzisothiazolinone Inhibitors of Monoacylglycerol Lipase: Exploring On-Target Activity Through Scaffold Decoration and In Situ Warhead Generation. [PDF]

ChemMedChem
Rocca E, Bedini A, Scalvini L, Galvani F, Castelli R, Sarcone L, Recchia A, Fanini F, Tran A, Rivara S, Spadoni G, Piomelli D, Mor M.   +12 more
europepmc   +1 more source

Psychological Stress Associated Bile Acid Reprogramming Promotes Hepatocellular Carcinoma Progression

Advanced Science, EarlyView.
Depression is increasingly recognized as a risk factor for chronic diseases, yet its biological impact on cancer remains unclear. Using data from more than 490 000 participants across three international cohorts, we show that depression significantly increases the risk of liver cancer.
Ruijiang Zeng, Mengmeng Wang, Kang Wang, Zhuo Xing, Yulong Hong, Tongtong Li, Geng Zong, Chong Yang, Dan Zhang, Zhangling Chen, Xin Jin   +10 more
wiley   +1 more source

Preparation of Monolithic Silica Nanocomposite Plates Embedding Fluorescent Graphene Quantum Dots via an Aqueous Sol-Gel Process. [PDF]

ACS Omega
Saito S, Iso Y, Isobe T.
europepmc   +1 more source

Oral Prebiotic Polysaccharide Hydrogels Sustaining Colon Antibody Release Alleviate Inflammatory Bowel Disease

Advanced Science, EarlyView.
An orally administered prebiotic polysaccharide hydrogel (predaGel) based on inulin and alginate‐dopamine is stable in the stomach, adheres to the intestine, and degrades slowly in the colon. It enables site‐specific delivery of anti‐TNF‐α and anti‐IL‐12/23 antibodies, scavenges reactive oxygen species, and remodels gut microbiota, offering effective ...
Xinyi Dong, Huan He, Li Cao, Fenghua Meng, Zhiyuan Zhong   +4 more
wiley   +1 more source

Activity of Secondary Metabolites from Marine-Derived <i>Trichoderma longibrachiatum</i> ST-27 Against <i>Vibrio harveyi</i>. [PDF]

Int J Mol Sci
Chen Y, Chen G, Hsieh CY, Wu Z, Tang X, Tsai PW, Chen YH.   +6 more
europepmc   +1 more source

Introducing Borsantrazole: A Trifunctional Boron‐Based Pyrazole That Extends the Lifespan of Amyotrophic Lateral Sclerosis Mice

Advanced Science, EarlyView.
Herein we report a boron‐based pyrazole, (Borsantrazole ‐ a small molecule that selectively targets oxidative stress) that significantly increases survival, reduces weight loss, delays disease onset, and affects global protein changes in the SOD1‐G37R mouse model of ALS.
Nitesh Sanghai, Rhonda Kelley, Ying Lao, M. Immanuel Reyes Madlangsakay, Prasanta Paul, M. Alejandra Llanes‐Cuesta, Jun‐Feng Wang, René P. Zahedi, Jiming Kong, Geoffrey K. Tranmer   +9 more
wiley   +1 more source

PFKFB4 Deubiquitination by USP10 Enhances Fumarate Metabolism to Orchestrate the KDM1A/Rad51 Axis and Confer Radioresistance in Lung Cancer

Advanced Science, EarlyView.
USP10 binds to and stabilizes PFKFB4, enhancing glycolytic ATP production, which activates the urea cycle and elevates fumarate. This inhibits histone demethylase KDM1A, leading to increased H3K4me1 enrichment at the Rad51 promoter and direct activation of Rad51 transcription, which confers lung cancer radioresistance. The PFKFB4 inhibitor 5MPN targets
Yunshang Chen, Zilong Wu, Yongqiang Yang, Ruoxin Fang, Huichan Xue, Rui Zhou, Gang Wu, Xiaohua Jie   +7 more
wiley   +1 more source

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