Results 291 to 300 of about 3,553,338 (335)

The key regulator circPDE3B promotes arsenic-induced bladder carcinogenesis by affecting STAT3 and NF-κB stability. [PDF]

Cell Biol Toxicol
Gao Y, Xu H, Zhao Q, Cai D, Zhou X, Chen X, Yuan S, Li D, Ning T, Dong X, Li M, Li G, Nan A.   +12 more
europepmc   +1 more source

Engineered Probiotics Mitigate Gut Barrier Dysfunction Induced by Nanoplastics

Advanced Science, EarlyView.
Intestinal barrier stability is vital for gut health. Plastic polyethylene terephthalate (PET) disrupts this barrier, causing inflammation and infections. This study encodes transforming growth factor‐β into EcN and modifies its surface with pH‐responsive polymer (EcNT@L), creating an oral drug delivery system to repair nano PET‐induced intestinal ...
Wenxin Chen, Qiyan Guo, Hong Li, Xue Chi, Xiang Ma, Yanqiong Tang, Quanfeng Liang, Zhu Liu, Yong Liu, Juanjuan Li   +9 more
wiley   +1 more source

Functional analyses of splice site variants in TCF12. [PDF]

Hum Genomics
Borst A, Schweitzer T, Horn D, Kunstmann E, König EM, Pluta N, Klopocki E.   +6 more
europepmc   +1 more source

Aqueous Two‐Phase Submicron Droplets Catalyze DNA Nanostructure Assembly for Confined Fluorescent Biosensing

Advanced Science, EarlyView.
Submicron droplets, formed by a polyethyleneglycol (PEG)/dextran aqueous two‐phase system·(ATPS), can act as catalytic centers that concentrate DNA and accelerate assembly kinetic in crowded environments. It highlights a cooperative mechanism wherein global crowding from PEG induces an excluded volume effect, while local crowding from dextran provides ...
Xiaoman Duan, Siyi Duan, Zhaoyu Han, Haoyue Lv, Haozhen Yu, Biwu Liu   +5 more
wiley   +1 more source

Magnetic‐Guided Delivery of Antisense Oligonucleotides for Targeted Transduction in Multiple Retinal Explant and Organoid Models

Advanced Science, EarlyView.
Magnetic field‐guided MNP@ATR‐ASO nanocomplexes facilitate the targeted delivery of ASOs to ganglion cells or photoreceptors within retinal explants, thereby enhancing the efficacy of ASOs in correcting pre‐mRNA splicing abnormalities. Furthermore, the nanocomplexes improve ASO penetration and delivery in human retinal and inner ear organoid models ...
Xiuhong Ye, Sihui Chen, Wei Xiong, Fan Wang, Hon Fai Chan, Haocheng Lai, Xiangyu Guo, Tingting Yang, Shuhao Shen, Hang Chen, Wenxuan Wang, Guei‐Sheung Liu, Yonglong Guo, Jiansu Chen   +13 more
wiley   +1 more source

Investigation of new autoantibodies in urothelial bladder cancer for biomarker discovery using immunoproteomics. [PDF]

Discov Oncol
Tabaei S, Zareinejad M, Haghshenas MR, Shakhssalim N, Gilany K, Stensballe A, Ghaderi A.   +6 more
europepmc   +1 more source

Targeting PFKFB4 Biomimetic Codelivery System Synergistically Enhances Ferroptosis to Suppress Small Cell Lung Cancer and Augments the Efficacy of Anti‐PD‐L1 Immunotherapy

Advanced Science, EarlyView.
In this study, a targeting PFKFB4 biomimetic codelivery system is developed to improve paclitaxel efficacy by inducing ferroptosis in SCLC. This system enhances immune cell infiltration and cytokine secretion, activating anti‐tumor immunity. Combined with anti‐PD‐L1, it boosts immune responses, offering a novel therapeutic strategy for overcoming ...
Xiang Liu, Jingjun He, Haoxuan Ying, Cuiying Chen, Chongyang Zheng, Peng Luo, Weiliang Zhu, Ting Wei, Bufu Tang, Jian Zhang   +9 more
wiley   +1 more source

PDGF-BB promotes oral submucosal fibrosis by driving phenotypic transformation and autophagy in oral mucosal fibroblasts through downregulation of circHIPK3. [PDF]

Sci Rep
Zhang H, Zhou Y, Jian N, Jiang C, Wang Q, Wang J.   +5 more
europepmc   +1 more source

PRMT1‐Mediated SWI/SNF Complex Recruitment via SMARCC1 Drives IGF2BP2 Transcription to Enhance Carboplatin Resistance in Head and Neck Squamous Cell Carcinoma

Advanced Science, EarlyView.
PRMT1 drives carboplatin resistance and tumor progression in head and neck squamous cell carcinoma (HNSCC) through a novel, methyltransferase‐independent mechanism. It recruits the SWI/SNF complex to activate IGF2BP2, promoting tumor growth and carboplatin resistance. PBX2 upregulates PRMT1, reinforcing this pathway. This study uncovers a non‐catalytic
Shixian Liu, Wentao Zhang, Weiwei Liu, Zhao Ding, Ruijing Zhang, Yuefeng Han, Zihao Niu, Mengdie Zhang, Hui Li, Dapeng Li, Zixi Wang, Jie Peng, Yu Wu, Yanxun Han, Zihui Xie, Jing Wu, Liang Qin, Zhongdong Hu, Xu Chen, Yunlong Hu, Yehai Liu, Shiyin Ma, Xiaojun Zha   +22 more
wiley   +1 more source

A Pentatricopeptide Repeat Protein Restores Fertility in Tadukan-Type Cytoplasmic Male Sterile Rice via the Cleavage of the Mitochondrial orf312 RNA. [PDF]

Physiol Plant
Takatsuka A, Iwai Y, Mireau H, Kazama T, Ichida H, Abe T, Igarashi K, Toriyama K.   +7 more
europepmc   +1 more source