Results 71 to 80 of about 856,230 (338)

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

SDS Agarose Gels for Analysis of Proteins

BioTechniques, 1998
A new agarose-based protein electrophoresis gel system is described. The system consists of a highly resolving agarose, MetaPhor® XR (FMC BioProducts, Rockland, ME, USA) dissolved in urea and TBE buffer and a stacking gel composed of a high gel strength ...
Minjie Wu, Noriko Kusukawa
doaj   +1 more source

The effect of high temperature on chemical structure of red blood corpuscles membranes for employees in ovens of Ramadi glass factory – Iraq. [PDF]

مجلة جامعة الانبار للعلوم الصرفة, 2012
This study include investigation the effects of high temperature on the chemical structure of RBCs membranes in thirty workers of the state coperation of glass industries in Ramadi - Iraq , thirty technicians and administrators for interior control and ...
Safa Kamil Al-Amin, M M Atea, M.Q. Al-Ani, A.A. Thaker   +3 more
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Rapid pre-gel visualization of proteins with mass spectrometry compatibility [PDF]

, 2010
Despite all of the prophecies of doom, gel electrophoresis is still prevalent in modern proteomic workflows. However, the currently used protein staining methods represent a serious bottleneck for a quick subsequent protein analysis using mass ...
Marco A. Mata-Gomez, Matthew T. Yasui, Robert Winkler   +2 more
core   +1 more source

Heterogeneity of wheat endosperm proteolipids (CM proteins) [PDF]

, 1975
Proteins extracted with CHCl3-MeOH from wheat endosperm have been fractionated by Sephadex G-100 and the 15 000–20 000 MW range fraction, designated CM protein, has been examined by combined electrofocusing (pH range 5–8) and electrophoresis (pH 3.2) and
Aragoncillo, Bietz, C. Aragoncillo, Charbonnier, Drysdale, F. Garcia-Olmedo, Folch, Folch-Pi, Garcia, Garcia, Hall, Huebner, Johnson, Johnson, Jones, Kaltsikes, M.A. Rodriguez-Loperena, Meredith, Meredith, Pilar Carbonero, Redman, Rohrlich, Tennenbaum, Waines, Waines, Wrigley, Wrigley, Zill   +27 more
core   +2 more sources

Overexpression of CDT1 inhibits cell cycle progression at S phase by interacting with the mini‐chromosome maintenance complex and causes DNA damage

FEBS Open Bio, EarlyView.
CDT1 is an essential protein for DNA replication licensing that loads the MCM complex, the eukaryotic replicative DNA helicase, onto replication origins. Overexpression of CDT1 induces cell cycle arrest at the S phase. Here we showed CDT1 inhibits the progression of replication forks by interacting with the MCM complex, leading to the stalling and ...
Takashi Tsuyama, Nonoka Takayama, Rina Tanaka, Yuuki Arai, Yohko Yamaguchi, Yuko Nawata, Yutaro Azuma, Shusuke Tada   +7 more
wiley   +1 more source

CHARACTERISATION OF IBD VIRAL PROTEINS IN SDS POLYACRYLAMIDE GEL ELECTROPHORESIS [PDF]

Journal of Veterinary and Animal Sciences, 2004
The field isolates of IBD virus was characterised using protein profile study. Four structural polypeptides of IBD virus with molecular weights of 91 K (VP1), 39 K (VP,), 32 K (VP3), and 28 K (VP4) and the additional polypeptide 47 K (VPX) preceusor ...
M. Parthiban, V. Thiagarajan
doaj  

Mass Spectrometry-based Proteomics in Acute Respiratory Distress Syndrome: A Powerful Modality for Pulmonary Precision Medicine

Chinese Medical Journal, 2016
Objective: Acute respiratory distress syndrome (ARDS) is an acute and lethal clinical syndrome that is characterized by hypoxemic respiratory failure and diffuse alveolar inflammatory damage. This review aimed to search and discuss the mass spectrometry (
Xue-Feng Xu, Hua-Ping Dai, Yan-Ming Li, Fei Xiao, Chen Wang   +4 more
doaj   +1 more source

A Mammalian Homolog of Drosophila melanogaster Transcriptional Coactivator Intersex Is a Subunit of the Mammalian Mediator Complex [PDF]

, 2003
The multiprotein Mediator complex is a coactivator required for transcriptional activation of RNA polymerase II transcribed genes by DNA binding transcription factors.
Banks, Charles A. S., Brower, Christopher S., Conaway, Joan Weliky, Conaway, Ronald C., Parmely, Tari J., Sato, Shigeo, Sorokina, Irina, Tomomori-Sato, Chieri   +7 more
core   +1 more source