Results 61 to 70 of about 365,939 (331)

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Spinodal phase separation in semi-interpenetrating polymer networks - polystyrene-cross-polymethacrylate [PDF]

, 1995
Morphology control in semi-interpenetrating polymer networks has been achieved by means of a two-step process, separating morphology formation and polymerization/crosslinking.
Beyer, Jenö, Graaf, Leontine A. de, Möller, Martin   +2 more
core   +1 more source

Percolation with Multiple Giant Clusters

, 2005
We study the evolution of percolation with freezing. Specifically, we consider cluster formation via two competing processes: irreversible aggregation and freezing.
Ben-Naim E, Ben-Naim E Krapivsky P L, Ben-Naim E Krapivsky P L, Broadbent S R, Cocco S, Drake R L, E Ben-Naim, Flory P J, Grimmett G, Hendricks E M, Janson S, Janson S, Krapivsky P L, P L Krapivsky, Sahimi M, Seinfeld J H, Singh P, Stauffer D, Wilf H S   +18 more
core   +1 more source

Phase separation processes in polymer solutions in relation to membrane formation [PDF]

, 1996
This review covers new experimental and theoretical physical research related to the formation of polymeric membranes by phase separation of a polymer solution, and to the morphology of these membranes.
Berg, J.W.A. van den, Dijkstra, P.J., Feijen, J., Witte, P. van de   +3 more
core   +2 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Multistep kinetic self-assembly of DNA-coated colloids

, 2013
Self-assembly is traditionally described as the process through which an initially disordered system relaxes towards an equilibrium ordered phase only driven by local interactions between its building blocks.
Di Michele, Lorenzo, Eiser, Erika, Foffi, Giuseppe, Kotar, Jurij, Nathan, Simon H., Varrato, Francesco   +5 more
core   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Pluronic F-68 and F-127 Based Nanomedicines for Advancing Combination Cancer Therapy

Pharmaceutics, 2023
Pluronics are amphiphilic triblock copolymers composed of two hydrophilic poly (ethylene oxide) (PEO) chains linked via a central hydrophobic polypropylene oxide (PPO).
Nisar Ul Khaliq, Juyeon Lee, Sangwoo Kim, Daekyung Sung, Hyungjun Kim   +4 more
doaj   +1 more source

Reentrant phase diagram and pH effects in cross-linked gelatin gels

, 2008
Experimental results have shown that the kinetics of bond formation in chemical crosslinking of gelatin solutions is strongly affected not only by gelatin and reactant concentrations but also by the solution pH.
D. Hellio Serughetti, de Gennes P. G., Doi M., E. Del Gado, Flory P. J., L. de Arcangelis, M. Djabourov, Stauffer D., T. Abete   +8 more
core   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source