Results 121 to 130 of about 2,108,289 (404)
Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma
Molecular Oncology, EarlyView.GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski +19 more
wiley +1 more source
GelsDespite the numerous ongoing research studies in the area of conducting polymer-based electrode materials for supercapacitors, the implementation has been inadequate for commercialization. Further understanding is required for the design and synthesis of
Mohammad Mizanur Rahman Khan +1 more
doaj +1 more source
Equilibrium gels of limited valence colloids
, 2017 Gels are low-packing arrested states of matter which are able to support stress. On cooling, limited valence colloidal particles form open networks stabilized by the progressive increase of the interparticle bond lifetime.
Sciortino, Francesco +1 more
core +1 more source
The pharmaceutical sciences have experienced tremendous growth and innovation over the past few decades, driven by the relentless pursuit of new therapies and the optimization of drug delivery systems. As we delve deeper into the complexities of disease mechanisms and patient needs, the field of pharmaceutical formulation and drug discovery has become ...
Pandey, Sumit, Vaishya, Prabhanshu
openaire +2 more sources
A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner
Molecular Oncology, EarlyView.We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley +1 more source
GelsGelatin is a promising biopolymer for edible coatings thanks to its low cost and gelling properties. However, its weak mechanical properties limit its use.
Danya E. Estrella-Osuna +9 more
doaj +1 more source
Psychopathy and emotional processing [PDF]
In deze studie is onderzocht of een verstoorde emotieverwerking een discriminerende factor is tussen psychopathie, gemeten met Hare’s (Hare, 1991) Psychopathy Checklist, en een antisociale persoonlijkheidsstoornis (ASPS), geclassificeerd volgens de ...
Slaats-Gels, M.E.
core
Weak and Strong Gels and the Emergence of the Amorphous Solid State
Gels, 2018 Gels are amorphous solids whose macroscopic viscoelastic response derives from constraints in the material that serve to localize the constituent molecules or particles about their average positions in space.
J. Douglas
semanticscholar +1 more source
Molecular Oncology, EarlyView.TRIM24 and TRIM28 are androgen receptor (AR) coregulators which exhibit increased expression with cancer progression. Both TRIM24 and TRIM28 combine to influence the response of castrate‐resistant prostate cancer (CRPC) cells to AR inhibitors by mediating AR signalling, regulation of MYC and upregulating VEGF to promote angiogenesis. Castrate‐resistant
Damien A. Leach +8 more
wiley +1 more source