Results 111 to 120 of about 11,702,336 (253)

Effects of Co-Exposure to Benzene, Toluene, and Xylene, Polymorphisms of microRNA Genes, and Their Interactions on Genetic Damage in Chinese Petrochemical Workers

Toxics
Benzene, toluene, and xylene (BTX) co-exist in human environments, yet their individual and combined effects on genetic damage at low exposure levels are not fully understood.
Shuangqi Li, Xiaojing Liao, Rui Ma, Na Deng, Haimei Wu, Zhaorui Zhang, Liping Chen, Qing Wang, Qilong Liao, Qianxi Li, Xinyi Ouyang, Yongmei Xiao, Qifei Deng   +12 more
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Effects of the family environment: Gene-environment interaction and passive gene-environment correlation

, 2008
The classical twin study provides a useful resource for testing hypotheses about how the family environment influences children’s development, including how genes can influence sensitivity to environmental effects. However, existing statistical models do
Thomas S. Price, Price, Thomas S., Thomas S. Price, Jaffee, Sara, Sara R. Jaffee   +4 more
core   +1 more source

Molecular Pathways Linking High-Fat Diet and PM_2.5 Exposure to Metabolically Abnormal Obesity: A Systematic Review and Meta-Analysis

Biomolecules
Obesity, influenced by environmental pollutants, can lead to complex metabolic disruptions. This systematic review and meta-analysis examined the molecular mechanisms underlying metabolically abnormal obesity caused by exposure to a high-fat diet (HFD ...
Sagrario Lobato, Víctor Manuel Salomón-Soto, Claudia Magaly Espinosa-Méndez, María Nancy Herrera-Moreno, Beatriz García-Solano, Ernestina Pérez-González, Facundo Comba-Marcó-del-Pont, Mireya Montesano-Villamil, Marco Antonio Mora-Ramírez, Claudia Mancilla-Simbro, Ramiro Álvarez-Valenzuela   +10 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Robust Tests for Additive Gene-Environment Interaction in Case-Control Studies Using Gene-Environment Independence [PDF]

, 2018
There have been recent proposals advocating the use of additive gene-environment interaction instead of the widely used multiplicative scale, as a more relevant public health measure.
Lee, AW, Schildkraut, JM, Kjaer, SK, Doherty, J, Tyrer, JP, Terry, KL, Leigh Pearce, C, Modugno, F, Ness, RB, Webb, PM, Cramer, DW, Ziogas, A, Lee, S, Fridley, B, Wu, AH, Kiemeney, L, Mukherjee, B, Massuger, L, Chang-Claude, J, Anton-Culver, H, Jensen, A, Moysich, KB, Ramus, SJ, Bandera, EV, Berchuck, A, Liu, G, Goode, EL, Anne Rossing, M, Gayther, SA, Pharoah, PD, Risch, H, Gentry-Maharaj, A, Menon, U   +32 more
core   +1 more source

Estimation of the Gene-Environment Interaction in Breast Cancer Patients

مجله اپیدمیولوژی ایران, 2006
Background and objectives: There is growing interest in assessing gene-environment interaction in the course of case-control studies. Difficulties related to the sampling of controls have led to the development of a range of non-traditional methods that
P Yavari, MA Pourhosseingholi
doaj  

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Interaction between Risk Single-Nucleotide Polymorphisms of Developmental Dyslexia and Parental Education on Reading Ability: Evidence for Differential Susceptibility Theory

Behavioral Sciences
While genetic and environmental factors have been shown as predictors of children’s reading ability, the interaction effects of identified genetic risk susceptibility and the specified environment for reading ability have rarely been investigated.
Qing Yang, Chen Cheng, Zhengjun Wang, Ximiao Zhang, Jingjing Zhao   +4 more
doaj   +1 more source