Results 121 to 130 of about 1,154,991 (281)

Gene-Environment interactions and the case of BMI and obesity: how much do they matter? [PDF]

, 2022
Yiyue Huangfu, Alberto Palloni, Hiram Beltrán‐Sánchez, Mary McEniry   +3 more
openalex   +1 more source

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

Molecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy, Samuel Hartzler, Paula A. Vargas Carranza, Shyaman Jayasundara, Madison E. Yates, Nimod D. Janson, Bozhi Liu, Annaleigh Benton, Majid Kazemian, Jason A. Hanna   +9 more
wiley   +1 more source

Izmir Mental Health Cohort for Gene-Environment Interaction in Psychosis (TürkSch): Assessment of the Extended and Transdiagnostic Psychosis Phenotype and Analysis of Attrition in a 6-Year Follow-Up of a Community-Based Sample [PDF]

, 2019
Umut Kırlı, Tolga Binbay, Hayriye Elbi, Marjan Drukker, Bülent Kayahan, Ferda Özkınay, Hüseyin Önay, Köksal Alptekın, Jim van Os   +8 more
openalex   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Supplemental Figure 1 from Assessment of Multifactor Gene–Environment Interactions and Ovarian Cancer Risk: Candidate Genes, Obesity, and Hormone-Related Risk Factors

, 2023
Joseph Usset, Rama Raghavan, Jonathan P. Tyrer, Valerie McGuire, Weiva Sieh, Penelope M. Webb, Jenny Chang‐Claude, Anja Rudolph, Hoda Anton‐Culver, Andrew Berchuck, Louise A. Brinton, Julie M. Cunningham, Anna DeFazio, Jennifer A. Doherty, Robert P. Edwards, Simon A. Gayther, Aleksandra Gentry‐Maharaj, Marc T. Goodman, Estrid Høgdall, Allan Jensen, Sharon E. Johnatty, Lambertus A. Kiemeney, Susanne K. Kjær, Melissa C. Larson, Galina Lurie, Leon F.A.G. Massuger, Usha Menon, Francesmary Modugno, Kirsten B. Moysich, Roberta B. Ness, Malcolm C. Pike, Susan J. Ramus, Mary Anne Rossing, Joseph H. Rothstein, Honglin Song, Pamela J. Thompson, David J. Van Den Berg, Robert A. Vierkant, Shan Wang‐Gohrke, Nicolas Wentzensen, Alice S. Whittemore, Lynne R. Wilkens, Anna H. Wu, Hannah Yang, Celeste Leigh Pearce, Joellen M. Schildkraut, Paul D.P. Pharoah, Ellen L. Goode, Brooke L. Fridley   +48 more
openalex   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Early exposure to environmental toxin contributes to neuronal vulnerability and axonal pathology in a model of familial ALS [PDF]

, 2011
Adult onset amyotrophic lateral sclerosis (ALS) arises due to progressive and irreversible functional deficits to the central nervous system, specifically the loss of motor neurons.
Christopher A. Shaw, Grace Lee
core   +1 more source

Supplementary Figure 1 from A Genome-Wide Gene-Based Gene–Environment Interaction Study of Breast Cancer in More than 90,000 Women

, 2023
Xiaoliang Wang, Hongjie Chen, Pooja Middha, Yu‐Ru Su, Manjeet K. Bolla, Joe Dennis, Alison M. Dunning, Michael Lush, Qin Wang, Kyriaki Michailidou, Paul D.P. Pharoah, John L. Hopper, Melissa C. Southey, Stella Koutros, Laura E. Beane Freeman, Jennifer Stone, Gad Rennert, Rana Shibli, Rachel A. Murphy, Kristan J. Aronson, Pascal Guénel, Thérèse Truong, Lauren R. Teras, James M. Hodge, Federico Canzian, Rudolf Kaaks, Hermann Brenner, Volker Arndt, Reiner Hoppe, Wing‐Yee Lo, Sabine Behrens, Arto Mannermaa, Veli‐Matti Kosma, Audrey Jung, Heiko Becher, Graham G. Giles, Christopher A. Haiman, Gertraud Maskarinec, Christopher G. Scott, Stacey J. Winham, Jacques Simard, Mark S. Goldberg, Wei Zheng, Jirong Long, Melissa A. Troester, Michael I. Love, Cheng Peng, Rulla M. Tamimi, A. Heather Eliassen, Montserrat García‐Closas, Jonine D. Figueroa, Thomas U. Ahearn, Rose Yang, D. Gareth Evans, Anthony Howell, Per Hall, Kamila Czene, Alicja Wolk, Dale P. Sandler, Jack A. Taylor, Anthony J. Swerdlow, Nick Orr, James V. Lacey, Sophia Wang, Håkan Olsson, Douglas F. Easton, Roger L. Milne, Li Hsu, Peter Kraft, Jenny Chang‐Claude, Sara Lindström   +70 more
openalex   +1 more source

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source