Results 141 to 150 of about 1,093,414 (290)

Single‐cell transcriptomics redefines focal neuroendocrine differentiation as a distinct prostate cancer pathology

Molecular Oncology, EarlyView.
Single‐cell transcriptomics of prostate cancer patient‐derived xenografts reveals distinct features of neuroendocrine (NE) subtypes. Tumours with focal NE differentiation (NED) share transcriptional programmes with adenocarcinoma, differing from large and small cell neuroendocrine prostate cancer (NEPC). Our work defines the molecular landscape of NEPC,
Rosalia Quezada Urban, Shivakumar Keerthikumar, Ashlee Clark, Hong Wang, Belinda Phipson, Andrew Bakshi, Andrew Ryan, Heather Thorne, Renea A. Taylor, Mitchell G. Lawrence, Gail P. Risbridger, Roxanne Toivanen, David L. Goode   +12 more
wiley   +1 more source

HLA and Cardiovascular Disease : Additional Comments : SYMPOSIUM ON GENE-ENVIRONMENT INTERACTION IN CARDIOVASCULAR DISEASES

, 1978
Setsuya Naito, Kikuo Arakawa, Hisashi Kanaya, Hisataka Doi, Yasushi Sasaki, Teruo Sakai, H Akaiwa, Akira Takeshita, Shoichiro Saito, Kiyokazu Toyoda   +9 more
openalex   +2 more sources

Agricultural management and plant selection interactively affect rhizosphere microbial community structure and nitrogen cycling. [PDF]

, 2019
BACKGROUND:Rhizosphere microbial communities are key regulators of plant performance, yet few studies have assessed the impact of different management approaches on the rhizosphere microbiomes of major crops.
Brisson, Vanessa L, Gaudin, Amélie CM, Kent, Angela D, Schmidt, Jennifer E   +3 more
core   +1 more source

Decrypting cancer's spatial code: from single cells to tissue niches

Molecular Oncology, EarlyView.
Spatial transcriptomics maps gene activity across tissues, offering powerful insights into how cancer cells are organised, switch states and interact with their surroundings. This review outlines emerging computational, artificial intelligence (AI) and geospatial approaches to define cell states, uncover tumour niches and integrate spatial data with ...
Cenk Celik, Shi Pan, Eloise Withnell, Hou Wang Lam, Maria Secrier   +4 more
wiley   +1 more source

The Role of Air Pollution Exposure and GSTM1-/GSTT1-Null Genotypes in Gestational Diabetes Mellitus Development: A Case–Control Study on Gene–Environment Interactions

Antioxidants
As gestational diabetes mellitus (GDM) rises as a major public health concern, various factors have been identified as potential contributors, with air pollution drawing increasing attention.
Ana Susa, Dragana Davidovic, Nadja Nikolic, Tamara Sljivancanin Jakovljevic, Vera Kujundzic, Sladjana Mihajlovic, Ljiljana Bogdanovic   +6 more
doaj   +1 more source

Commentary: Facing the Challenge of Gene-Environment Interaction: The Two-by-Four Table and Beyond [PDF]

, 2001
Lorenzo D. Botto, Muin J. Khoury
openalex   +1 more source

Developmental Systems Theory as a Process Theory [PDF]

, 2018
Griffiths and Russell D. Gray (1994, 1997, 2001) have argued that the fundamental unit of analysis in developmental systems theory should be a process – the life cycle – and not a set of developmental resources and interactions between those resources ...
Griffiths, Paul Edmund, Stotz, Karola
core  

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source

Gene-environment interaction and personality/behaviour

Annals of General Psychiatry, 2006
Göktürk Camilla, Wargelius Hanna, Olerud Ingrid, Sjöberg Rickard, Nilsson Kent, Lindström Leif, Hallman Jarmila, Oreland Lars, Öhrvik John, Leppert Jerzy   +9 more
doaj   +1 more source

PCOS and the Genome: Is the Genetic Puzzle Still Worth Solving?

Biomedicines
Background: Polycystic ovary syndrome (PCOS) is a complex and multifactorial disorder affecting reproductive, endocrine, and metabolic functions in women of reproductive age.
Mario Palumbo, Luigi Della Corte, Dario Colacurci, Mario Ascione, Giuseppe D’Angelo, Giorgio Maria Baldini, Pierluigi Giampaolino, Giuseppe Bifulco   +7 more
doaj   +1 more source