Results 161 to 170 of about 1,163,174 (254)

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source

GE-IA-NAM: gene-environment interaction analysis via imaging-assisted neural additive model. [PDF]

Bioinformatics
Li J, Xu Y, Ma S, Fang K.
europepmc   +1 more source

Re-analysis and meta-analysis of summary statistics from gene-environment interaction studies. [PDF]

Bioinformatics, 2023
Pham DT, Westerman KE, Pan C, Chen L, Srinivasan S, Isganaitis E, Vajravelu ME, Bacha F, Chernausek S, Gubitosi-Klug R, Divers J, Pihoker C, Marcovina SM, Manning AK, Chen H.   +14 more
europepmc   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Association between hot spring residency and dry eye disease: a crossover gene-environment interaction (GxE) study in Taiwan. [PDF]

Hum Genomics
Wu HY, Chang KJ, Chiu W, Wang CY, Lin YC, Hsu YT, Wen YC, Chiang PH, Chen YH, Dai HJ, Lu CH, Chen YC, Tsai HY, Chen YC, Hsu CH, Chiou SH, Yang YP, Hsieh AR, Hsu CC.   +18 more
europepmc   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

PIGEON: a statistical framework for estimating gene-environment interaction for polygenic traits. [PDF]

Nat Hum Behav
Miao J, Song G, Wu Y, Hu J, Wu Y, Basu S, Andrews JS, Schaumberg K, Fletcher JM, Schmitz LL, Lu Q.   +10 more
europepmc   +1 more source

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source

High-Dimensional Gene-Environment Interaction Analysis. [PDF]

Annu Rev Stat Appl
Wu M, Li Y, Ma S.
europepmc   +1 more source

Pathological imaging-assisted cancer gene-environment interaction analysis. [PDF]

Biometrics, 2023
Fang K, Li J, Zhang Q, Xu Y, Ma S.
europepmc   +1 more source