Results 221 to 230 of about 1,154,991 (281)

ReninAngiotensinAldosterone System Gene Polymorphisms and Coronary Artery Disease: Detection of Gene-Gene and Gene-Environment Interactions

, 2012
En‐Zhi Jia, Zhenxia Xu, Chang–Yan Guo, Li Li, Yan Gu, Tiebing Zhu, Lian‐Sheng Wang, Kejiang Cao, Wen‐Zhu Ma, Zhijian Yang   +9 more
openalex   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Case‐only gene–environment interaction between ALAD tagSNPs and occupational lead exposure in prostate cancer

, 2014
Christine Neslund‐Dudas, Albert M. Levin, Andrew Rundle, Jennifer Beebe‐Dimmer, Cathryn H. Bock, Nora L. Nock, Michelle Jankowski, Indrani Datta, Richard Krajenta, Q. Ping Dou, Bharati Mitra, Deliang Tang, Benjamin A. Rybicki   +12 more
openalex   +1 more source

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

FEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold, Janik Riese, Lancelot Seillier, Mark Kühnel, Julia Pannhausen, Charlotte O. J. Fröhlich, Christian Martin, Peter Boor, Matthias Saar, Danny D. Jonigk, Nadine T. Gaisa, Michael Rose   +11 more
wiley   +1 more source

Efficient and accurate framework for genome-wide gene-environment interaction analysis in large-scale biobanks. [PDF]

Nat Commun
Ma Y, Zhao Y, Zhang JF, Bi W.
europepmc   +1 more source

Gene environment interactions in asthma

, 2007
Sally McLeish, Steve Turner
openalex   +1 more source

The role of lipid metabolism in neuronal senescence

FEBS Open Bio, EarlyView.
Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari, Eleftheria Panagiotidou, Nektarios Tavernarakis   +2 more
wiley   +1 more source

High-Fat Diet-Fed Kcnq1 Mutant Mice Have Reduced Pancreatic β-Cell Mass via Gene-Environment Interaction. [PDF]

Diabetes Metab J
Asahara SI, Inoue H, Ihara Y, Teruyama K, Imai A, Hara C, Hara M, Seike M, Yokoi A, Kido N, Suzuki H, Kanno A, Inaba Y, Watanabe H, Shioi G, Kimura-Koyanagi M, Matsumoto M, Inoue H, Nakayama KI, Ogawa W, Kasuga M, Kido Y.   +21 more
europepmc   +1 more source

Bayesian variable selection for hierarchical gene–environment and gene–gene interactions

, 2014
Changlu Liu, Jianzhong Ma, Christopher I. Amos   +2 more
openalex   +2 more sources

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

FEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li, Hiroko Ohmiya, Sou Sakamoto, Masato Yugami, Akiko Oki, Makoto Furusawa, Yan Ling   +6 more
wiley   +1 more source