Results 91 to 100 of about 8,668,830 (261)
BMC Primary CareBackground The management in primary care (PC) of the patients with Heart Failure (HF) is different from the management hospital, in a special way compared to cardiology departments.
Sergio Cinza-Sanjurjo +9 more
doaj +1 more source
Journal of Integrative NeuroscienceBackground: Heat shock proteins (HSPs) play a critical role in the molecular mechanisms of ischemic stroke (IS). A possible role for HSP40 family proteins in atherosclerosis progression has already been revealed; however, to date ...
Ksenia A. Kobzeva +5 more
doaj +1 more source
Mechanisms of resistance to viruses
Plant Protection Science, 2002 Resistance associated with a hypersensitive response (HR) and subsequent development of necrotic lesions (cell death) at the sites of virus infection can restrict virus movement in plants. Genes for HR are dominant and act on a gene-for-gene basis.
J.P.T. Valkonen
doaj +1 more source
Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis
FEBS Letters, EarlyView.This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng +8 more
wiley +1 more source
Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy
FEBS Letters, EarlyView.The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley +1 more source
Transcriptome-wide gene-gene interaction associations elucidate pathways and functional enrichment of complex traits. [PDF]
PLoS Genet, 2023 Evans LM +7 more
europepmc +1 more source
Unlocking the potential of cell‐permeable nanobodies for intracellular applications
FEBS Letters, EarlyView.This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés +2 more
wiley +1 more source
Imputation of quantitative genetic interactions in epistatic MAPs by interaction propagation matrix completion [PDF]
, 2014 A popular large-scale gene interaction discovery platform is the Epistatic Miniarray Profile (E-MAP). E-MAPs benefit from quantitative output, which makes it possible to detect subtle interactions.
Zupan, Blaz, Zitnik, Marinka
core
On gene interaction in Indian dairy cattle
, 1988 Considering thirty two Holstein Friesian-Shaiwal grade (generation) means obtained from the adjusted data of seven Military Farms (pertaining to the period 1945-79) as dependent variable (y) and the coefficients of the parameters of components of mean in
Narain, P., Sharma, B. S.
core +1 more source
Cell Cycle Control Gene-Gene Interaction Model in Pregnancy Loss
Online Journal of Health & Allied Sciences, 2016 Early stages of individual development are defined by active cell division and differentiation processes. Intercellular signaling molecules as well as proliferation control and DNA stabilizing factors act as basic functional groups.
Mashkina EV +3 more
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