Results 81 to 90 of about 8,668,830 (261)

RNA‐related functions of BRCA2 in transcription, replication, and genome stability

FEBS Letters, EarlyView.
Beyond its role in homologous recombination, BRCA2 regulates R‐loop homeostasis, DNA–RNA hybrid resolution, RNA polymerase II dynamics, and transcriptional activation. Disruption of any of these functions can contribute to genome instability, inflammatory signaling, and tumorigenesis. BRCA2 is a central tumor suppressor protein best known for its roles
Lucia Alvaro‐Aranda, Sreerama Chaitanya Sridhara, Aura Carreira   +2 more
wiley   +1 more source

Feedback regulation of Ran gene expression by Ran protein

, 2011
National Natural Science Foundation of China [30830084]; Hi-Tech Research and Development Program of China (863 program of China) [2010AA09Z403]; Ministry of Agriculture, China [201103034]; Chinese Universities Scientific FundRan, an abundant GTPase that
Wang, Jiajia, Zhang, Xiaobo, Zhao, Zhe, 赵哲   +3 more
core  

Stria Gravidarum Is Genetic But Not Related With Collagen Gene Polymorphism [PDF]

, 2013
BACKGROUND: Striae Gravidarum (SG) is a common problem that complicates the pregnancies. We aimed to evaluate the possible etiologic factors of SG and the possible importance of collagen polymorphism on SG.
Gungor, Cakir A. N., Gencer, M., Uysal, A., Isik, S., Oguz, S., Uludag, A., Sılan, Fatma   +6 more
core   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Gene2vec: distributed representation of genes based on co-expression

BMC Genomics, 2019
Background Existing functional description of genes are categorical, discrete, and mostly through manual process. In this work, we explore the idea of gene embedding, distributed representation of genes, in the spirit of word embedding.
Jingcheng Du, Peilin Jia, Yulin Dai, Cui Tao, Zhongming Zhao, Degui Zhi   +5 more
doaj   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

TLR Signaling Pathway Gene Polymorphisms, Gene–Gene and Gene–Environment Interactions in Allergic Rhinitis

Journal of Inflammation Research, 2022
Ruo-Xi Chen,1,* Meng-Di Dai,1,* Qing-Zhao Zhang,1 Mei-Ping Lu,1 Mei-Lin Wang,2,3 Min Yin,1,4 Xin-Jie Zhu,1 Zhong-Fei Wu,1 Zheng-Dong Zhang,2,3 Lei Cheng1,4 1Department of Otorhinolaryngology & Clinical Allergy Center, The First Affiliated ...
Chen RX, Dai MD, Zhang QZ, Lu MP, Wang ML, Yin M, Zhu XJ, Wu ZF, Zhang ZD, Cheng L   +9 more
doaj  

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

A gene-centered C. elegans protein-DNA interaction network

, 2006
SummaryTranscription regulatory networks consist of physical and functional interactions between transcription factors (TFs) and their target genes. The systematic mapping of TF-target gene interactions has been pioneered in unicellular systems, using ...
Walhout, Albertha J.M., Mango, Susan E., Deplancke, Bart, Mukhopadhyay, Arnab, Reece-Hoyes, John S., Martinez, Natalia J., Doucette-Stamm, Lynn, Hope, Ian A., Grove, Christian A., Sequerra, Reynaldo, Ao, Wanyuan, Walhout, Albertha J. M., Elewa, Ahmed M., Tissenbaum, Heidi A., Hope, I. A., Martinez, Natalia Julia, Sequerra, R., Mango, S. E., Ao, W., Walhout, A. J., Walhout, Albertha J M, Grove, C. A., Deplancke, B., Tissenbaum, H. A., Doucette-Stamm, L., Elewa, A. M., Martinez, N. J., Mukhopadhyay, A., Reece-Hoyes, J. S.   +28 more
core   +1 more source