Results 11 to 20 of about 8,668,830 (261)

Update on Viral Gene Therapy Clinical Trials for Retinal Diseases [PDF]

, 2022
In 2001, the first large animal was successfully treated with a gene therapy that restored its vision. Lancelot, the Briard dog that was treated, suffered from a human childhood blindness called Leber's congenital amaurosis type 2.
Cheng, Shun-Yun, Punzo, Claudio
core   +1 more source

How ambient temperature affects the heading date of foxtail millet (Setaria italica)

Frontiers in Plant Science, 2023
Foxtail millet (Setaria italica), a short-day plant, is one of the important crops for food security encountering climate change, particularly in regions where it is a staple food.
Ya-Chen Huang, Yu-tang Wang, Yee-ching Choong, Hsin-ya Huang, Yu-ru Chen, Tzung-Fu Hsieh, Tzung-Fu Hsieh, Yann-rong Lin, Yann-rong Lin   +8 more
doaj   +1 more source

Structural Differences between Pri-miRNA Paralogs Promote Alternative Drosha Cleavage and Expand Target Repertoires

Cell Reports, 2019
Summary: MicroRNA (miRNA) processing begins with Drosha cleavage, the fidelity of which is critical for downstream processing and mature miRNA target specificity.
Xavier Bofill-De Ros, Wojciech K. Kasprzak, Yuba Bhandari, Lixin Fan, Quinn Cavanaugh, Minjie Jiang, Lisheng Dai, Acong Yang, Tie-Juan Shao, Bruce A. Shapiro, Yun-Xing Wang, Shuo Gu   +11 more
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An association study in the Taiwan Biobank elicits the GABAA receptor genes GABRB3, GABRA5, and GABRG3 as candidate loci for sleep duration in the Taiwanese population

BMC Medical Genomics, 2021
Background Gamma-aminobutyric acid type A (GABAA) receptors mainly mediate the effects of gamma-aminobutyric acid, which is the primary inhibitory neurotransmitter in the central nervous system.
Sheue-Jane Hou, Shih-Jen Tsai, Po-Hsiu Kuo, Wan-Yu Lin, Yu-Li Liu, Albert C. Yang, Eugene Lin, Tsuo-Hung Lan   +7 more
doaj   +1 more source

Exhaustive Genome-Wide Search for SNP-SNP Interactions Across 10 Human Diseases

G3: Genes, Genomes, Genetics, 2016
The identification of statistical SNP-SNP interactions may help explain the genetic etiology of many human diseases, but exhaustive genome-wide searches for these interactions have been difficult, due to a lack of power in most datasets.
William Murk, Andrew T. DeWan
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Gene-Gene Interaction between APOA5 and USF1: Two Candidate Genes for the Metabolic Syndrome [PDF]

, 2009
Objective: The metabolic syndrome, a major cluster of risk factors for cardiovascular diseases, shows increasing prevalence worldwide. Several studies have established associations of both apolipoprotein A5 (APOA5) gene variants and upstream stimulatory ...
Wichmann, Heinz-Erich, Holzapfel, C., Singmann, Paula, Grallert, Harald, Singmann, P., Wichmann, H.-E., Holzapfel, Christina, Illig, T., Klingenspor, Martin, Klingenspor, M., Grallert, H., Herder, C., Illig, Thomas, Rathmann, Wolfgang, Baumert, Jens, Meisinger, Christa, Rathmann, W., Baumert, J.J., Klopp, Norman, Klopp, N., Herder, Christian, Meisinger, C., Singmann, Paula;Baumert, Jens;Herder, Christian;Meisinger, Christa;Holzapfel, Christina;Klopp, Norman;Wichmann, H.-Erich;Klingenspor, Martin;Rathmann, Wolfgang;Illig, Thomas;Grallert, Harald, Singmann, P., Baumert, J., Herder, C., Meisinger, C., Holzapfel, C., Klopp, N., Wichmann, H.-E., Klingenspor, M., Rathmann, W., Illig, T., Grallert, H.   +23 more
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Gene-Based Methods to Detect Gene-Gene Interaction in R: The GeneGeneInteR Package

Journal of Statistical Software, 2020
GeneGeneInteR is an R package dedicated to the detection of an association between a case-control phenotype and the interaction between two sets of biallelic markers (single nucleotide polymorphisms or SNPs) in case-control genome-wide associations ...
Mathieu Emily, Nicolas Sounac, Florian Kroell, Magalie Houée-Bigot   +3 more
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Gene Network Biological Validity Based on Gene-Gene Interaction Relevance

The Scientific World Journal, 2014
In recent years, gene networks have become one of the most useful tools for modeling biological processes. Many inference gene network algorithms have been developed as techniques for extracting knowledge from gene expression data.
Francisco Gómez-Vela, Norberto Díaz-Díaz   +1 more
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A network view of human immune system and virus-human interaction

Frontiers in Immunology, 2022
The immune system is highly networked and complex, which is continuously changing as encountering old and new pathogens. However, reductionism-based researches do not give a systematic understanding of the molecular mechanism of the immune response and ...
Kang Tang, Kang Tang, Jing Tang, Jing Tang, Jinfeng Zeng, Jinfeng Zeng, Wei Shen, Wei Shen, Min Zou, Min Zou, Chi Zhang, Chi Zhang, Qianru Sun, Qianru Sun, Xiaoyan Ye, Chunwei Li, Caijun Sun, Caijun Sun, Siyang Liu, Siyang Liu, Guozhi Jiang, Guozhi Jiang, Xiangjun Du, Xiangjun Du, Xiangjun Du   +24 more
doaj   +1 more source

Information-theoretic gene-gene and gene-environment interaction analysis of quantitative traits

BMC Genomics, 2009
Background The purpose of this research was to develop a novel information theoretic method and an efficient algorithm for analyzing the gene-gene (GGI) and gene-environmental interactions (GEI) associated with quantitative traits (QT).
Liu Song, Sucheston Lara, Chanda Pritam, Zhang Aidong, Ramanathan Murali   +4 more
doaj   +1 more source