Results 21 to 30 of about 8,668,830 (261)

Robust Gene-Gene Interaction Analysis in Genome Wide Association Studies. [PDF]

PLoS ONE, 2015
Genome-wide association studies (GWAS) have successfully discovered hundreds of associations between genetic variants and complex traits. Most GWAS have focused on the identification of single variants.
Yongkang Kim, Taesung Park
doaj   +1 more source

Simulating gene-gene and gene-environment interactions in complex diseases: Gene-Environment iNteraction Simulator 2

BMC Bioinformatics, 2012
Background The analysis of complex diseases is an important problem in human genetics. Because multifactoriality is expected to play a pivotal role, many studies are currently focused on collecting information on the genetic and environmental factors ...
Pinelli Michele, Scala Giovanni, Amato Roberto, Cocozza Sergio, Miele Gennaro   +4 more
doaj   +1 more source

Association of the CCR5 gene with juvenile idiopathic arthritis [PDF]

, 2010
The CC chemokine receptor 5 (CCR5) has been shown to be important in the recruitment of T-helper cells to the synovium, where they accumulate, drive the inflammatory process and the consequent synovitis and joint destruction.
Martin, P., BSPAR Study Group, Barton, A., UKRAG Consortium, Worthington, J., Gardner-Medwin, J. [CAPS and BSPAR Study Groups], Thomson, W., W Thomson, Flynn, E., A Hinks, E Flynn, J Packham, Packham, J., Hinks, A., S Eyre, J Worthington, Eyre, S.; id_orcid, Eyre, S., Barton, A.; id_orcid, P Martin, Childhood Arthritis Prospective Study (CAPS), Martin, P.; id_orcid, A Barton   +22 more
core   +1 more source

The lipoprotein lipase S447X polymorphism and plasma lipids

Journal of Lipid Research, 2004
We studied 4,058 subjects from a representative sample of the Singapore population 1) to determine the association between the S447X polymorphism at the LPL locus and serum lipid concentration in Chinese, Malays, and Asian Indians living in Singapore and
J. Lee, C.S. Tan, K.S. Chia, C.E. Tan, S.K. Chew, J.M. Ordovas, E.S. Tai   +6 more
doaj   +1 more source

A genetic ensemble approach for gene-gene interaction identification

BMC Bioinformatics, 2010
Background It has now become clear that gene-gene interactions and gene-environment interactions are ubiquitous and fundamental mechanisms for the development of complex diseases.
Ho Joshua WK, Yang Pengyi, Zomaya Albert Y, Zhou Bing B   +3 more
doaj   +1 more source

Gene-gene interaction indifferent GC tissue samples.

, 2018
(a). Edges represents jointly contribute gene-gene interaction, illustrates TP73 gene-gene network upper show the first 25 genes that interact with TP73 gene. (b) down figure show four genes that interact with TP73.
Sana Akhtar Alvi (5745980), Esam Ibraheem Azhar (5745989), Ali Sawan (5745986), Muhammad Imran Naseer (338314), Hussein Sheikh Ali Mohamoud (5745977), Asif Ahmed Jiman-Fatani (5745983), Fehmida Bibi (3555899), Isse Ali (5745974), Muhammad Yasir (3555896)   +8 more
core   +1 more source

Edge-weighting of gene expression graphs [PDF]

, 2009
In recent years, considerable research efforts have been directed to micro-array technologies and their role in providing simultaneous information on expression profiles for thousands of genes.
Kerr, Gráinne, Crane, Martin, DIMITRI PERRIN, HEATHER J. RUSKIN, Ruskin, Heather J., Perrin, Dimitri, MARTIN CRANE, GRAINNE KERR, Ruskin, Heather J   +8 more
core   +3 more sources

Identification of drug and protein-protein interaction network among stress and depression: A bioinformatics approach

Informatics in Medicine Unlocked, 2023
The fields of data mining, computational biology, and statistics have been combined to form the massive research area of bioinformatics. In the areas of genetics, education, and healthcare, bioinformatics integrates the tools available in different ...
Md. Abul Basar, Md. Faruk Hosen, Bikash Kumar Paul, Md. Rakibul Hasan, S.M. Shamim, Touhid Bhuyian   +5 more
doaj   +1 more source

Effect of DFPP on Ferroptosis in Peripheral Blood CD14+ Monocytes of Hyperlipidemic Patients Involving the ACSL4/LPCAT3/ALOX5 Pathway

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Hyperlipidemia is a major risk factor for atherosclerotic cardiovascular disease (ASCVD). Although statins are the cornerstone of lipid‐lowering therapy, their use may be limited in some patients by adverse effects. This study evaluated the possible impact of non‐drug treatment using double‐filtration plasmapheresis (DFPP) on CD14+
Yun Cheng, Lan Li, Qingmei Yang, Meipeng Wu   +3 more
wiley   +1 more source

Gene-gene interaction: COLEC11 and MASP2 genotypes frequencies in patients with chronic CD and healthy controls.

, 2019
Gene-gene interaction: COLEC11 and MASP2 genotypes frequencies in patients with chronic CD and healthy controls.
Iara J. Messias-Reason (535489), Thaisa Lucas Sandri (4030688), Meral Esen (211790), Kárita Cláudia Freitas Lidani (6597503), Elias Einig (6597506), Fabiana Antunes Andrade (3797332), Benjamin Mordmüller (211841), Angelica Beate Winter Boldt (439804)   +7 more
core   +1 more source