Results 21 to 30 of about 7,356,147 (250)

A network view of human immune system and virus-human interaction

Frontiers in Immunology, 2022
The immune system is highly networked and complex, which is continuously changing as encountering old and new pathogens. However, reductionism-based researches do not give a systematic understanding of the molecular mechanism of the immune response and ...
Kang Tang, Kang Tang, Jing Tang, Jing Tang, Jinfeng Zeng, Jinfeng Zeng, Wei Shen, Wei Shen, Min Zou, Min Zou, Chi Zhang, Chi Zhang, Qianru Sun, Qianru Sun, Xiaoyan Ye, Chunwei Li, Caijun Sun, Caijun Sun, Siyang Liu, Siyang Liu, Guozhi Jiang, Guozhi Jiang, Xiangjun Du, Xiangjun Du, Xiangjun Du   +24 more
doaj   +1 more source

Gene Network Biological Validity Based on Gene-Gene Interaction Relevance

The Scientific World Journal, 2014
In recent years, gene networks have become one of the most useful tools for modeling biological processes. Many inference gene network algorithms have been developed as techniques for extracting knowledge from gene expression data.
Francisco Gómez-Vela, Norberto Díaz-Díaz   +1 more
doaj   +1 more source

Information-theoretic gene-gene and gene-environment interaction analysis of quantitative traits

BMC Genomics, 2009
Background The purpose of this research was to develop a novel information theoretic method and an efficient algorithm for analyzing the gene-gene (GGI) and gene-environmental interactions (GEI) associated with quantitative traits (QT).
Liu Song, Sucheston Lara, Chanda Pritam, Zhang Aidong, Ramanathan Murali   +4 more
doaj   +1 more source

Robust Gene-Gene Interaction Analysis in Genome Wide Association Studies. [PDF]

PLoS ONE, 2015
Genome-wide association studies (GWAS) have successfully discovered hundreds of associations between genetic variants and complex traits. Most GWAS have focused on the identification of single variants.
Yongkang Kim, Taesung Park
doaj   +1 more source

Gene Therapy for Fibrodysplasia Ossificans Progressiva: Feasibility and Obstacles [PDF]

, 2022
Fibrodysplasia ossificans progressiva (FOP) is a rare and devastating genetic disease, in which soft connective tissue is converted into heterotopic bone through an endochondral ossification process.
Shim, Jae-Hyuck, Delai, Patricia L R, Madhuri, Vrisha, De Cunto, Carmen L, de Ruiter, Ruben D, Schoenmaker, Ton, Zasloff, Michael, Friedman, Clive S, Gao, Guangping, Cho, Tae-Joon, Morhart, Rolf, Grunwald, Zvi, di Rocco, Maja, Haga, Nobuhiko, de Vries, Teun J, Hsiao, Edward C, Pals, Gerard, Netelenbos, Coen, Diecidue, Robert J, Kaplan, Frederick, Smilde, Bernard J, Scott, Christiaan, Eekhoff, Elisabeth M W, Pignolo, Robert J, Micha, Dimitra   +24 more
core   +1 more source

Simulating gene-gene and gene-environment interactions in complex diseases: Gene-Environment iNteraction Simulator 2

BMC Bioinformatics, 2012
Background The analysis of complex diseases is an important problem in human genetics. Because multifactoriality is expected to play a pivotal role, many studies are currently focused on collecting information on the genetic and environmental factors ...
Pinelli Michele, Scala Giovanni, Amato Roberto, Cocozza Sergio, Miele Gennaro   +4 more
doaj   +1 more source

The lipoprotein lipase S447X polymorphism and plasma lipids

Journal of Lipid Research, 2004
We studied 4,058 subjects from a representative sample of the Singapore population 1) to determine the association between the S447X polymorphism at the LPL locus and serum lipid concentration in Chinese, Malays, and Asian Indians living in Singapore and
J. Lee, C.S. Tan, K.S. Chia, C.E. Tan, S.K. Chew, J.M. Ordovas, E.S. Tai   +6 more
doaj   +1 more source

A genetic ensemble approach for gene-gene interaction identification

BMC Bioinformatics, 2010
Background It has now become clear that gene-gene interactions and gene-environment interactions are ubiquitous and fundamental mechanisms for the development of complex diseases.
Ho Joshua WK, Yang Pengyi, Zomaya Albert Y, Zhou Bing B   +3 more
doaj   +1 more source

Edge-weighting of gene expression graphs [PDF]

, 2009
In recent years, considerable research efforts have been directed to micro-array technologies and their role in providing simultaneous information on expression profiles for thousands of genes.
Kerr, Gráinne, Crane, Martin, DIMITRI PERRIN, HEATHER J. RUSKIN, Ruskin, Heather J., Perrin, Dimitri, MARTIN CRANE, GRAINNE KERR, Ruskin, Heather J   +8 more
core   +3 more sources

Identification of drug and protein-protein interaction network among stress and depression: A bioinformatics approach

Informatics in Medicine Unlocked, 2023
The fields of data mining, computational biology, and statistics have been combined to form the massive research area of bioinformatics. In the areas of genetics, education, and healthcare, bioinformatics integrates the tools available in different ...
Md. Abul Basar, Md. Faruk Hosen, Bikash Kumar Paul, Md. Rakibul Hasan, S.M. Shamim, Touhid Bhuyian   +5 more
doaj   +1 more source