Results 91 to 100 of about 1,574,651 (334)

Gene-Environment Interaction in a Conditional NMDAR-Knockout Model of Schizophrenia

Frontiers in Behavioral Neuroscience, 2019
Interactions between genetic and environmental risk factors take center stage in the pathology of schizophrenia. We assessed if the stressor of reduced environmental enrichment applied in adulthood provokes deficits in the positive, negative or cognitive
Alexei M. Bygrave, Simonas Masiulis, Dimitri M. Kullmann, David M. Bannerman, Dennis Kätzel, Dennis Kätzel, Dennis Kätzel   +6 more
doaj   +1 more source

Circulating histones as clinical biomarkers in critically ill conditions

FEBS Letters, EarlyView.
Circulating histones are emerging as promising biomarkers in critical illness due to their diagnostic, prognostic, and therapeutic potential. Detection methods such as ELISA and mass spectrometry provide reliable approaches for quantifying histone levels in plasma samples.
José Luis García‐Gimenez, Juan Carlos Ruiz‐Rodríguez, Ricard Ferrer, Raquel Durá, Antonio Artigas, Iván Bajaña, David Bolado López de Andujar, Irene Cánovas‐Cervera, Adrián Ceccato, Luis Chiscano‐Camón, Elena Climent‐Martinez, Georgia García Fernández, Gemma Goma, Verónica Monforte, Beatriz Quevedo‐Sánchez, Adolf Ruiz‐Sanmartín, Antonio Sierra‐Rivera, Nieves Carbonell Monleón   +17 more
wiley   +1 more source

Genome-Wide Gene-Environment Interaction Analysis Using Set-Based Association Tests

Frontiers in Genetics, 2019
The identification of gene-environment interactions (G × E) may eventually guide health-related choices and medical interventions for complex diseases. More powerful methods must be developed to identify G × E.
Wan-Yu Lin, Wan-Yu Lin, Ching-Chieh Huang, Yu-Li Liu, Shih-Jen Tsai, Shih-Jen Tsai, Po-Hsiu Kuo, Po-Hsiu Kuo   +7 more
doaj   +1 more source

The challenge of causal inference in gene-environment interaction research: leveraging research designs from the social sciences.

American Journal of Public Health, 2013
The integration of genetics and the social sciences will lead to a more complex understanding of the articulation between social and biological processes, although the empirical difficulties inherent in this integration are large.
Jason M. Fletcher, D. Conley
semanticscholar   +1 more source

Autism risk factors: genes, environment, and gene-environment interactions

Dialogues in Clinical Neuroscience, 2012
The aim of this review is to summarize the key findings from genetic and epidemiological research, which show that autism is a complex disorder resulting from the combination of genetic and environmental factors. Remarkable advances in the knowledge of genetic causes of autism have resulted from the great efforts made in the field of genetics.
Pauline Chaste, Marion Leboyer
openaire   +3 more sources

Single‐cell insights into the role of T cells in B‐cell malignancies

FEBS Letters, EarlyView.
Single‐cell technologies have transformed our understanding of T cell–tumor cell interactions in B‐cell malignancies, revealing new T‐cell subsets, functional states, and immune evasion mechanisms. This Review synthesizes these findings, highlighting the roles of T cells in pathogenesis, progression, and therapy response, and underscoring their ...
Laura Llaó‐Cid
wiley   +1 more source

Gene-environment interaction and Mendelian randomisation

Revue Neurologique, 2019
Genetic factors only account for up to a third of the cases of Parkinson's disease (PD), while the remaining cases are of unknown aetiology. Environmental exposures (such as pesticides or heavy metals) and the interaction with genetic susceptibility factors (summarized in the concept of impaired xenobiotic metabolism) are believed to play a major role ...
Pierre Kolber, Rejko Krüger, Rejko Krüger   +2 more
openaire   +4 more sources

Identification of functional and diverse circulating cancer‐associated fibroblasts in metastatic castration‐naïve prostate cancer patients

Molecular Oncology, EarlyView.
Cancer‐associated fibroblasts (CAFs) promote cancer growth, invasion (metastasis), and drug resistance. Here, we identified functional and diverse circulating CAFs (cCAFs) in patients with metastatic prostate cancer (mPCa). cCAFs were found in higher numbers and were functional and diverse in mPCa patients versus healthy individuals, suggesting their ...
Richell Booijink, Leon W. M. M. Terstappen, Eshwari Dathathri, Khrystany Isebia, Jaco Kraan, John Martens, Ruchi Bansal   +6 more
wiley   +1 more source

Surfaceome: a new era in the discovery of immune evasion mechanisms of circulating tumor cells

Molecular Oncology, EarlyView.
In the era of immunotherapies, many patients either do not respond or eventually develop resistance. We propose to pave the way for proteomic analysis of surface‐expressed proteins called surfaceome, of circulating tumor cells. This approach seeks to identify immune evasion mechanisms and discover potential therapeutic targets. Circulating tumor cells (
Doryan Masmoudi, Jérome Vialaret, Christophe Hirtz, Catherine Alix‐Panabières   +3 more
wiley   +1 more source

Modeling Gene-Environment Interaction for the Risk of Non-hodgkin Lymphoma

Frontiers in Oncology, 2019
Background: Non-hodgkin lymphoma (NHL) is one of the most common and deadly cancers. There is limited analysis of gene-environment interactions for the risk of NHL. This study intends to explore the interactions between genetic variants and environmental
Jiahui Zhang, Xibiao Ye, Cuie Wu, Hua Fu, Wei Xu, Wei Xu, Pingzhao Hu, Pingzhao Hu, Pingzhao Hu   +8 more
doaj   +1 more source