Results 101 to 110 of about 922,149 (303)

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Gene-Environment Interaction in a Conditional NMDAR-Knockout Model of Schizophrenia

Frontiers in Behavioral Neuroscience, 2019
Interactions between genetic and environmental risk factors take center stage in the pathology of schizophrenia. We assessed if the stressor of reduced environmental enrichment applied in adulthood provokes deficits in the positive, negative or cognitive
Alexei M. Bygrave, Simonas Masiulis, Dimitri M. Kullmann, David M. Bannerman, Dennis Kätzel, Dennis Kätzel, Dennis Kätzel   +6 more
doaj   +1 more source

MDR analysis of gene-environment interaction.

, 2013
MDR analysis of gene-environment interaction.
Jia Su (128774), Lindan Ji (451496), Lina Zhang (112887), Xiaobo Cai (451497), Lijuan Fei (451498), Lissy Lazar (443376), Yaping Zhang (296604), Jin Xu (31283), Lin Wang (11986)   +8 more
core   +1 more source

Prenatal stress-induced programming of genome-wide promoter DNA methylation in 5-HTT-deficient mice [PDF]

, 2014
The serotonin transporter gene (5-HTT/SLC6A4)-linked polymorphic region has been suggested to have a modulatory role in mediating effects of early-life stress exposure on psychopathology rendering carriers of the low-expression short (s)-variant more ...
Haaf, T., Lesch, K.P., Scholz, C. J., Strekalova, T., Eijssen, L.M.; id_orcid, Scholz, C.J., Steinbusch, H.W., Schraut, K. G., Weidner, M.T., Eijssen, L. M. T., Eijssen, L.M., Van den Hove, D. L., Steinbusch, H. W. M., Lesch, K. P., Schmitt, A.G., Van den Hove, D.L., Weidner, M. T., Reif, A., Ortega, G., El Hajj, N., Schmitt, A. G., Jakob, S.B., Jakob, S. B., Domschke, K., Schraut, K.G.   +24 more
core   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Gene-Environment Interaction Loci Associated with Refractive Error: SCAMPI Analysis

Ophthalmology Science
Purpose: To compare the performance of a novel method for identifying candidate gene-environment interaction loci, Scalable Cauchy Aggregate test using Multiple Phenotypes to test Interactions (SCAMPI) (doi:10.1101/2024.09.10.612314v1), to widely used ...
Xi He, MSc, MD, Louise Terry, PhD, Jeremy A. Guggenheim, PhD, Naomi Allen, Tariq Aslam, Denize Atan, Konstantinos Balaskas, Sarah Barman, Jenny Barrett, Paul Bishop, Graeme Black, Tasanee Braithwaite, Roxana Carare, Usha Chakravarthy, Michelle Chan, Sharon Chua, Annegret Dahlmann-Noor, Alexander Day, Parul Desai, Bal Dhillon, Andrew Dick, Alexander Doney, Cathy Egan, Sarah Ennis, Paul Foster, Marcus Fruttiger, John Gallacher, David (Ted) Garway-Heath, Jane Gibson, Jeremy Guggenheim, Chris Hammond, Alison Hardcastley, Simon Harding, Ruth Hogg, Pirro Hysi, Pearse Keane, Sir Peng Tee Khaw, Anthony Khawaja, Gerassimos Lascaratos, Thomas Littlejohns, Andrew Lotery, Robert Luben, Phil Luthert, Tom Macgillivray, Sarah Mackie, Savita Madhusudhan, Bernadette Mcguinness, Gareth Mckay, Martin Mckibbint, Tony Moore, James Morgan, Eoin O'Sullivan, Richard Oram, Chris Owen, Praveen Patel, Euan Paterson, Tunde Peto, Axel Petzold, Nikolas Pontikos, Jugnoo Rahi, Alicja Rudnicka, Naveed Sattar, Jay Self, Panagiotis Sergouniotis, Sobha Sivaprasad, David Steel, Irene Stratton, Nicholas Strouthidis, Cathie Sudlow, Zihan Sun, Robyn Tapp, Dhanes Thomas, Mervyn Thomas, Emanuele Trucco, Adnan Tufail, Ananth Viswanathan, Veronique Vitart, Mike Weedon, Katie Williams, Cathy Williams, Jayne Woodside, Max Yates, Yalin Zheng   +82 more
doaj   +1 more source

The BridgeDb framework: standardized access to gene, protein and metabolite identifier mapping services [PDF]

, 2010
BACKGROUND: Many complementary solutions are available for the identifier mapping problem. This creates an opportunity for bioinformatics tool developers.
Kelder, T.A.J., Alexander R Pico, van Iersel, Martijn P, Hanspers, K, van Iersel, M.P., Pico, A.R., Isaac Ho, Conklin, B.R., Conklin, BR, Pico, AR, Evelo, C.T.A., Kelder, T, Evelo, Chris T, Kelder, Thomas, Martijn P van Iersel, Evelo, CT, van Iersel, MP, Evelo, C.T.A.; id_orcid, Gao, J., Conklin, Bruce R, Ho, I, Thomas Kelder, Ho, I., Bruce R Conklin, Kristina Hanspers, Gao, J, Ho, Isaac, Chris T Evelo, Hanspers, Kristina, Jianjiong Gao, Pico, Alexander R, Gao, Jianjiong, Hanspers, K.   +32 more
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

A platform for the remote conduct of gene-environment interaction studies.

PLoS ONE, 2013
BackgroundGene-environment interaction studies offer the prospect of robust causal inference through both gene identification and instrumental variable approaches. As such they are a major and much needed development.
John Gallacher, Rory Collins, Paul Elliott, Stephen Palmer, Paul Burton, Clive Mitchell, Gareth John, Ronan Lyons   +7 more
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source