Results 121 to 130 of about 11,702,420 (293)

Gene–environment interactions [PDF]

Genetics in Medicine, 2015
openaire   +2 more sources

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Study on the Interaction Between C3 Gene Polymorphism and Environment in Patients with Type 2 Diabetes Combined with Coronary Artery Disease

Diabetes, Metabolic Syndrome and Obesity
Haitang Qiu,1,* Shajidan Abudureyimu,1,* Mengjia Liu,1 Fen Liu,2 Ying Gao1 1Department of Comprehensive Internal Medicine, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, People’s Republic of China; 2State Key ...
Qiu H, Abudureyimu S, Liu M, Liu F, Gao Y   +4 more
doaj  

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Effects of the family environment: Gene-environment interaction and passive gene-environment correlation

, 2008
The classical twin study provides a useful resource for testing hypotheses about how the family environment influences children’s development, including how genes can influence sensitivity to environmental effects. However, existing statistical models do
Thomas S. Price, Price, Thomas S., Thomas S. Price, Jaffee, Sara, Sara R. Jaffee   +4 more
core   +1 more source

Polymorphism in Genes Encoding HSP40 Family Proteins is Associated with Ischemic Stroke Risk and Brain Infarct Size: A Pilot Study

Journal of Integrative Neuroscience
Background: Heat shock proteins (HSPs) play a critical role in the molecular mechanisms of ischemic stroke (IS). A possible role for HSP40 family proteins in atherosclerosis progression has already been revealed; however, to date ...
Ksenia A. Kobzeva, Denis E. Gurtovoy, Alexey V. Polonikov, Vladimir M. Pokrovsky, Evgeny A. Patrakhanov, Olga Y. Bushueva   +5 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Robust Tests for Additive Gene-Environment Interaction in Case-Control Studies Using Gene-Environment Independence [PDF]

, 2018
There have been recent proposals advocating the use of additive gene-environment interaction instead of the widely used multiplicative scale, as a more relevant public health measure.
Lee, AW, Schildkraut, JM, Kjaer, SK, Doherty, J, Tyrer, JP, Terry, KL, Leigh Pearce, C, Modugno, F, Ness, RB, Webb, PM, Cramer, DW, Ziogas, A, Lee, S, Fridley, B, Wu, AH, Kiemeney, L, Mukherjee, B, Massuger, L, Chang-Claude, J, Anton-Culver, H, Jensen, A, Moysich, KB, Ramus, SJ, Bandera, EV, Berchuck, A, Liu, G, Goode, EL, Anne Rossing, M, Gayther, SA, Pharoah, PD, Risch, H, Gentry-Maharaj, A, Menon, U   +32 more
core   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Estimation of the Gene-Environment Interaction in Breast Cancer Patients

مجله اپیدمیولوژی ایران, 2006
Background and objectives: There is growing interest in assessing gene-environment interaction in the course of case-control studies. Difficulties related to the sampling of controls have led to the development of a range of non-traditional methods that
P Yavari, MA Pourhosseingholi
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