Results 121 to 130 of about 15,130,803 (334)
Comparing the paths of Hedgehog release in artificial and natural settings
FEBS Letters, EarlyView.Hh morphogens require solubilization factors to overcome their tight association with the plasma membrane and signal to distant cells, but the precise functions of these factors are controversial. Here, we use published in vivo observations as the most relevant evidence to test their suggested functions and discuss contradictions and gaps between in ...
Janna Puschmann, Kay Grobe
wiley +1 more source
A Nonlinear Model for Gene-Based Gene-Environment Interaction
, 2016 A vast amount of literature has confirmed the role of gene-environment (G×E) interaction in the etiology of complex human diseases. Traditional methods are predominantly focused on the analysis of interaction between a single nucleotide polymorphism (SNP)
Jian Sa +4 more
core +1 more source
Gene-environment interaction involving recently identified colorectal cancer susceptibility loci
Cancer Epidemiology, Biomarkers and Prevention, 2014 Background: Genome-wide association studies have identified several single nucleotide polymorphisms (SNPs) that are associated with risk of colorectal cancer.
Elizabeth D. Kantor +45 more
semanticscholar +1 more source
How structural disorder and polyelectrolyte properties of prothymosin α enable its large interactome
FEBS Letters, EarlyView.In this review, complexes of the fully disordered and highly negatively charged prothymosin α are collected, described, and discussed. Linked to its poly‐electrostatic character, prothymosin α engages a large interactome through multiple different binding modes ranging from fully disordered complexes to short linear motif (SLiM)‐driven interactions ...
Ketty C. Tamburrini +3 more
wiley +1 more source
Gene-Environment Interaction: Definitions and Study Designs [PDF]
, 2008 Dr. Ruth Ottman first discussed different models of gene-environment interactions and then delved into designs of studies attempting to elucidate such interactions.
Ruth Ottman
core +1 more source
Gene-environment interactions in Autism Spectrum Disorder (ASD)
, 2022 Autism Spectrum Disorder (ASD) is a heterogeneous neurodevelopmental disorder characterized by deficits in social communication and interaction and repetitive and restricted behaviors.
Santos, João Xavier
core +1 more source
FEBS Letters, EarlyView.Which brain hemisphere controls writing? This review synthesizes all five functional transcranial Doppler studies of writing (handwriting and typing) published to date in adults and children. Right‐handers show left‐hemispheric dominance for the linguistic component of writing (written word generation), whereas findings for left‐handers remain ...
Marietta Papadatou‐Pastou
wiley +1 more source
Gene - environment interaction in programming hippocampal plasticity: focus on adult neurogenesis
Frontiers in Molecular Neuroscience, 2015 Interactions between genes and environment are a critical feature of development and both contribute to shape individuality. They are at the chore of vulnerability / resiliency for mental illnesses.
Muriel eKoehl, Muriel eKoehl
doaj +1 more source
Mitochondrial translation and coordinated cytosolic translation in metabolic homeostasis and disease
FEBS Letters, EarlyView.Mitochondrial function depends on coordinated protein production from the nuclear and mitochondrial genomes. This review highlights how cytosolic and mitochondrial translation, mRNA localization, protein import, and respiratory complex assembly are integrated to maintain mitochondrial proteostasis and function.
Boseon Kim +4 more
wiley +1 more source
Genome-Wide Gene-Environment Interaction Analysis Using Set-Based Association Tests
Frontiers in Genetics, 2019 The identification of gene-environment interactions (G × E) may eventually guide health-related choices and medical interventions for complex diseases. More powerful methods must be developed to identify G × E.
Wan-Yu Lin +7 more
doaj +1 more source