Results 111 to 120 of about 15,130,803 (334)

Robust Tests for Additive Gene-Environment Interaction in Case-Control Studies Using Gene-Environment Independence [PDF]

, 2017
There have been recent proposals advocating the use of additive gene-environment interaction instead of the widely used multiplicative scale, as a more relevant public health measure.
Consortium, for the Ovarian Cancer Association, Kiemeney, Lambertus, Joellen M Schildkraut, Susanne K Kjaer, Jonathan P Tyrer, Rossing, Mary Anne, Ness, Roberta B, Argyrios Ziogas, Anton-Culver, Hoda, Elisa V Bandera, Simon A Gayther, Mukherjee, Bhramar, Celeste Leigh Pearce, Schildkraut, Joellen M, Kirsten B Moysich, Pearce, Celeste Leigh, Cramer, Daniel W, Seunggeun Lee, Alice W Lee, Francesmary Modugno, Lee, Alice W, Bandera, Elisa V, Moysich, Kirsten B, Gentry-Maharaj, Aleksandra, Gang Liu, Tyrer, Jonathan P, Pharoah, Paul D, Brooke L Fridley, Usha Menon, Fridley, Brooke L, null null, Modugno, Francesmary, Ramus, Susan J, Lambertus Kiemeney, Roberta B Ness, Wu, Anna H, Jenny Chang-Claude, Leon Massuger, Menon, Usha, Jensen, Allan, Lee, Seunggeun, Liu, Gang, Paul D Pharoah, Harvey Risch, Daniel W Cramer, Kjaer, Susanne K, Kathryn L Terry, Risch, Harvey, Anna H Wu, Chang-Claude, Jenny, Penelope M Webb, Jennifer A Doherty, Ziogas, Argyrios, Bhramar Mukherjee, Mary Anne Rossing, Webb, Penelope M, Aleksandra Gentry-Maharaj, Susan J Ramus, Hoda Anton-Culver, Massuger, Leon, Allan Jensen, Terry, Kathryn L, Gayther, Simon A, Goode, Ellen L, Ellen L Goode, Andrew Berchuck, Berchuck, Andrew, Doherty, Jennifer A, Wu, A.H., Pearce, C.L., Lee, Alice W., Massuger, L.F., Risch, H., Kiemeney, L.A., Bandera, E.V.   +74 more
core   +2 more sources

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Incorporating gene-environment interaction in testing for association with rare genetic variants

Human Heredity, 2014
Objectives: The incorporation of gene-environment interactions could improve the ability to detect genetic associations with complex traits. For common genetic variants, single-marker interaction tests and joint tests of genetic main effects and gene ...
Han Chen, J. Meigs, J. Dupuis
semanticscholar   +1 more source

Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis

FEBS Letters, EarlyView.
This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng, Shen‐Shin Chang, Feng‐Wei Chen, Ying‐Chieh Su, Thanh Phuong Nguyen, Yu‐Wei Hsiao, Jhih‐Ying Chi, Hsin‐Yin Liang, Ju‐Ming Wang   +8 more
wiley   +1 more source

Gene-Environment interaction of genetic variants with alcohol and smoking in CP.

, 2016
Gene-Environment interaction of genetic variants with alcohol and smoking in CP.
Kshaunish Das (2183604), Priyanka Banerjee (485749), Pramod K. Garg (2183622), Syed Jafar Mehdi (2183618), Ankita Agrawal (2183614), Anil K. Giri (2183608), Surinder Rana (2183626), Shallu Midha (2183606), Ritika Lakhotia (2183620), Samir Mohindra (2183602), Deepak K. Bhasin (2183610), Rajan Dhingra (2183616), Ismeet Kaur (2183612), Saurabh Ghosh (1234137), Dwaipayan Bharadwaj (126561), Ramesh Kumar G. (2183624)   +15 more
core   +1 more source

Gene-environment interactions within a precision environmental health framework

Cell Genomics
Summary Understanding the complex interplay of genetic and environmental factors in disease etiology and the role of gene-environment interactions (GEIs) across human development stages is important.
A. Motsinger-Reif, David M. Reif, F. Akhtari, J. House, C. Ryan Campbell, Kyle P. Messier, D. Fargo, Tiffany A. Bowen, Srikanth S. Nadadur, Charles P. Schmitt, Kristianna G. Pettibone, D. Balshaw, Cindy P. Lawler, Shelia A. Newton, G. Collman, A. Miller, B. Merrick, Yuxia Cui, Benedict Anchang, Q. Harmon, Kimberly A. McAllister, R. Woychik   +21 more
semanticscholar   +1 more source

Is the Gene-Environment Interaction Paradigm Relevant to Genome-Wide Studies? The Case of Education and Body Mass Index

Demography, 2014
This study uses data from the Framingham Heart Study to examine the relevance of the gene-environment interaction paradigm for genome-wide association studies (GWAS).
Jason D. Boardman, Benjamin Domingue, Casey L. Blalock, Brett C. Haberstick, K. Harris, M. McQueen   +5 more
semanticscholar   +1 more source

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

Gene-Gene Interaction between APOA5 and USF1: Two Candidate Genes for the Metabolic Syndrome [PDF]

, 2009
Objective: The metabolic syndrome, a major cluster of risk factors for cardiovascular diseases, shows increasing prevalence worldwide. Several studies have established associations of both apolipoprotein A5 (APOA5) gene variants and upstream stimulatory ...
Wichmann, Heinz-Erich, Holzapfel, C., Singmann, Paula, Grallert, Harald, Singmann, P., Wichmann, H.-E., Holzapfel, Christina, Illig, T., Klingenspor, Martin, Klingenspor, M., Grallert, H., Herder, C., Illig, Thomas, Rathmann, Wolfgang, Baumert, Jens, Meisinger, Christa, Rathmann, W., Baumert, J.J., Klopp, Norman, Klopp, N., Herder, Christian, Meisinger, C., Singmann, Paula;Baumert, Jens;Herder, Christian;Meisinger, Christa;Holzapfel, Christina;Klopp, Norman;Wichmann, H.-Erich;Klingenspor, Martin;Rathmann, Wolfgang;Illig, Thomas;Grallert, Harald, Singmann, P., Baumert, J., Herder, C., Meisinger, C., Holzapfel, C., Klopp, N., Wichmann, H.-E., Klingenspor, M., Rathmann, W., Illig, T., Grallert, H.   +23 more
core   +1 more source

Characteristics of the phenotypes in prevalent and incident cases of heart failure in primary care: IBERICAN study

BMC Primary Care
Background The management in primary care (PC) of the patients with Heart Failure (HF) is different from the management hospital, in a special way compared to cardiology departments.
Sergio Cinza-Sanjurjo, Miguel Ángel Prieto-Díaz, Vicente Pallarés-Carratalá, Rafael M. Micó-Pérez, Sonsoles Velilla-Zancada, Alfonso Barquilla-García, Leovigildo Ginel-Mendoza, Antonio Segura-Fragoso, Vicente Martín-Sánchez, José Polo-García   +9 more
doaj   +1 more source