Results 111 to 120 of about 922,149 (303)

Gene-gene and gene-environment interactions in meta-analysis of genetic association studies.

, 2015
Extensive genetic studies have identified a large number of causal genetic variations in many human phenotypes; however, these could not completely explain heritability in complex diseases.
Sui-Lung Su, Lin, John, Hsin-Yi Yang, Chi-Ming Chu, Sui-Lung Su (306303), Chu, Chi-Ming, Chin Lin (28524), Su, Sui-Lung, John Lin (273102), Yang, Hsin-Yi, Chin Lin, John Lin, Chi-Ming Chu (306302), Lin, Chin, Hsin-Yi Yang (398581)   +14 more
core   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Modeling Gene-Environment Interaction for the Risk of Non-hodgkin Lymphoma

Frontiers in Oncology, 2019
Background: Non-hodgkin lymphoma (NHL) is one of the most common and deadly cancers. There is limited analysis of gene-environment interactions for the risk of NHL. This study intends to explore the interactions between genetic variants and environmental
Jiahui Zhang, Xibiao Ye, Cuie Wu, Hua Fu, Wei Xu, Wei Xu, Pingzhao Hu, Pingzhao Hu, Pingzhao Hu   +8 more
doaj   +1 more source

A framework to identify physiological responses in microarray based gene expression studies: selection and interpretation of biologically relevant genes

, 2008
In whole genome microarray studies major gene expression changes are easily identified, but it is a challenge to capture small, but biologically important, changes.
Boer, J.M., Mariman, E.C.M., Feskens, E.J.M., Bovee-Oudenhoven, I.M.J., Bovee Oudenhoven, I.M., Boer, J.M.A., Keijer, J., Heidema, A.G., Rodenburg, W., Rodenburg, G.C.H., Mariman, E.C.   +10 more
core   +1 more source

Radical mechanisms in nitrosamine- and nitrosamide-induced whole-genome gene expression modulations in Caco-2 cells. [PDF]

, 2010
N-nitroso compounds (NOC) may be implicated in human colon carcinogenesis, but the toxicological mechanisms involved have not been elucidated. Since it was previously demonstrated that nitrosamines and nitrosamides, representing two classes of NOC ...
Briedé, J.J., Khampang, R., de Kok, T.M.C.M., Hebels, D.G.A.J., Hebels, D.G.A.J.; id_orcid, Kleinjans, J.C.S.   +5 more
core   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

GIS mapping and gene-environment interaction

, 2014
Gene-environment interaction and GIS mapping were two major methods for spatial data analysis in public health sector. In the past, researchers often used the gene-environment interaction method to study the relationship between the environmental ...
Zhu, Jialing
core  

Effects of the family environment: Gene-environment interaction and passive gene-environment correlation

, 2008
The classical twin study provides a useful resource for testing hypotheses about how the family environment influences children’s development, including how genes can influence sensitivity to environmental effects. However, existing statistical models do
Thomas S. Price, Price, Thomas S., Thomas S. Price, Jaffee, Sara, Sara R. Jaffee   +4 more
core   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source