Results 131 to 140 of about 922,149 (303)

Association study on two vitamin D receptor gene polymorphisms and vitamin D metabolites in multiple sclerosis

, 2009
BACKGROUND: An association of two single-nucleotide polymorphisms (SNPs) of the vitamin D receptor (VDR) gene, Apal (rs7975232) and Taql (rs731236), with multiple sclerosis (MS) has been reported in a Caucasian population.
Damoiseaux, J.G.M.C., Menheere, P., Smolders, J., Tervaert, J.W., Hupperts, R.   +4 more
core   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Estimation of the Gene-Environment Interaction in Breast Cancer Patients

مجله اپیدمیولوژی ایران, 2006
Background and objectives: There is growing interest in assessing gene-environment interaction in the course of case-control studies. Difficulties related to the sampling of controls have led to the development of a range of non-traditional methods that
P Yavari, MA Pourhosseingholi
doaj  

A Nonlinear Model for Gene-Based Gene-Environment Interaction

, 2016
A vast amount of literature has confirmed the role of gene-environment (G×E) interaction in the etiology of complex human diseases. Traditional methods are predominantly focused on the analysis of interaction between a single nucleotide polymorphism (SNP)
Jian Sa, Yuehua Cui, Tao He, Xu Liu, Guifen Liu   +4 more
core   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Mamm Genome [PDF]

Identifying gene-environment interactions is a central challenge in the quest to understand susceptibility to complex, multi-factorial diseases. Developing an understanding of how inter-individual variability in inherited genetic variation alters the ...

core  

Robust Tests for Additive Gene-Environment Interaction in Case-Control Studies Using Gene-Environment Independence [PDF]

, 2018
There have been recent proposals advocating the use of additive gene-environment interaction instead of the widely used multiplicative scale, as a more relevant public health measure.
Lee, AW, Schildkraut, JM, Kjaer, SK, Doherty, J, Tyrer, JP, Terry, KL, Leigh Pearce, C, Modugno, F, Ness, RB, Webb, PM, Cramer, DW, Ziogas, A, Lee, S, Fridley, B, Wu, AH, Kiemeney, L, Mukherjee, B, Massuger, L, Chang-Claude, J, Anton-Culver, H, Jensen, A, Moysich, KB, Ramus, SJ, Bandera, EV, Berchuck, A, Liu, G, Goode, EL, Anne Rossing, M, Gayther, SA, Pharoah, PD, Risch, H, Gentry-Maharaj, A, Menon, U   +32 more
core  

Gene expression profiling in primary mouse hepatocytes discriminates true from false-positive genotoxic compounds.

, 2010
Well-established in vitro methods for testing the genotoxic potency of chemicals-such as the Ames/Salmonella test, the mouse lymphoma assay, the micronucleus test and the chromosomal aberration test-show a high false-positive rate for predicting in vivo ...
Mathijs, K., Lizarraga Lopez, D., Brauers, K.J., van Delft, J.H.M., Jennen, D.G.J., Kleinjans, J.C.S.   +5 more
core   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source