Results 91 to 100 of about 15,130,803 (334)

Gene-gene and gene-environment interactions in meta-analysis of genetic association studies. [PDF]

, 2015
Extensive genetic studies have identified a large number of causal genetic variations in many human phenotypes; however, these could not completely explain heritability in complex diseases.
Sui-Lung Su, Lin, John, Hsin-Yi Yang, Chi-Ming Chu, Sui-Lung Su (306303), Chu, Chi-Ming, Chin Lin (28524), Su, Sui-Lung, John Lin (273102), Yang, Hsin-Yi, Chin Lin, John Lin, Chi-Ming Chu (306302), Lin, Chin, Hsin-Yi Yang (398581), Lin Chin, Chu Chi-Ming, Su Sui-Lung, Yang Hsin-Yi, Lin John   +19 more
core   +1 more source

Epigenetic metaphors: an interdisciplinary translation of encoding and decoding

New Genetics and Society, 2019
Looking at the new and often disputed science of epigenetics, we examined the challenges faced by scientists when they communicate scientific research to the public. We focused on the use of metaphors to illustrate notions of epigenetics and genetics. We
Aviad Raz, Gaëlle Pontarotti, Jonathan B. Weitzman   +2 more
doaj   +1 more source

Gene-environment interaction and maternal arsenic methylation efficiency during pregnancy

Environment International, 2019
Background: Single nucleotide polymorphisms (SNPs) may influence arsenic methylation efficiency, affecting arsenic metabolism. Whether gene-environment interactions affect arsenic metabolism during pregnancy remains unclear, which may have implications ...
Shangzhi Gao, Md. Golam Mostofa, Quazi Quamruzzaman, Mahmudur Rahman, Mohammad Rahman, Li Su, Yu-mei Hsueh, Marc Weisskopf, Brent Coull, David C. Christiani   +9 more
doaj   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Gene-Environment Interaction in Psychological Traits and Disorders

, 2011
There has been an explosion of interest in studying gene-environment interactions (GxE) as they relate to the development of psychopathology. In this article, I review different methodologies to study gene-environment interaction, providing an overview ...
Danielle M. Dick
core   +1 more source

Combined effects of maternal periconceptional environmental exposures and infant cardiac transcription factor polymorphisms on congenital heart disease risk

Annals of Medicine
Background Congenital heart disease (CHD) is a leading cause of neonatal morbidity and mortality, with a complex aetiology involving genetic and environmental factors. Cardiac transcription factors, such as NKX2.5, GATA4 and TBX5, are essential for heart
Jianhui Wei, Peng Huang, Letao Chen, Tubao Yang, Tingting Wang, Ziye Li, Lizhang Chen, Jiabi Qin   +7 more
doaj   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

A case-only approach for assessing gene-sex interaction in human longevity [PDF]

As one aspect of the complex feature of longevity, gene-sex interaction plays an important role in influencing human life span. With advances in molecular genetics, more studies aimed at assessing gene-sex interaction are expected.
Karen Andersen-Ranberg, Bernard Jeune, Anatoli I. Yashin, Moniek De Maat, James W. Vaupel, Qihua Tan, Else M. Bladbjerg, Kaare Christensen   +7 more
core  

Effects of the family environment: Gene-environment interaction and passive gene-environment correlation

, 2008
The classical twin study provides a useful resource for testing hypotheses about how the family environment influences children’s development, including how genes can influence sensitivity to environmental effects. However, existing statistical models do
Thomas S. Price, Price, Thomas S., Thomas S. Price, Jaffee, Sara, Sara R. Jaffee   +4 more
core   +1 more source