Results 171 to 180 of about 1,095,697 (331)

The tumor–microbe connection

Molecular Oncology, EarlyView.
Tumor‐associated bacteria (TAB) dynamically influence cancer biology by modulating tumor progression, metastatic spread, and therapeutic efficacy. Their presence redefines the tumor microenvironment (TME) as a microbial–host interface, yet mechanistic insights remain limited. Understanding TAB colonization routes, functional impacts, and crosstalk with
Gerlanda Vella, Maria Rescigno
wiley   +1 more source

Gene–environment interaction and aetiology of cancer: what does it mean and how can we measure it? [PDF]

, 2002
Paul Brennan
openalex   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Research Seeks Links Between Cancer, Gene-Environment Interactions

, 2000
Norma J. Nelson
openalex   +1 more source

Variance Components Models for Gene–Environment Interaction in Quantitative Trait Locus Linkage Analysis [PDF]

, 2002
Shaun Purcell, Pak C. Sham
openalex   +1 more source

Gene/environment interactions [PDF]

American Journal of Hypertension, 1997
openaire   +2 more sources

Understanding and measuring mechanical signals in the tumor stroma

FEBS Open Bio, EarlyView.
This review discusses cancer‐associated fibroblast subtypes and their functions, particularly in relation to extracellular matrix production, as well as the development of 3D models to study tumor stroma mechanics in vitro. Several quantitative techniques to measure tissue mechanical properties are also described, to emphasize the diagnostic and ...
Fàtima de la Jara Ortiz, Chiara Cimmino, Maurizio Ventre, Alessandra Cambi   +3 more
wiley   +1 more source

Environmental and genetic risk factors and gene-environment interactions in the pathogenesis of chronic obstructive lung disease.

, 2000
Robert Walter, David Gottlieb, George O'connor   +2 more
openalex   +1 more source

Airborne Occupational Exposure and ABO Phenotype: An Example of Gene-Environment Interaction in Ischaemic Heart Disease? [PDF]

, 2002
K. W. Lee, G. Y. H. Lip
openalex   +1 more source

Bioengineering facets of the tumor microenvironment in 3D tumor models: insights into cellular, biophysical and biochemical interactions

FEBS Open Bio, EarlyView.
The tumor microenvironment is a dynamic, multifaceted complex system of interdependent cellular, biochemical, and biophysical components. Three‐dimensional in vitro models of the tumor microenvironment enable a better understanding of these interactions and their impact on cancer progression and therapeutic resistance.
Salma T. Rafik, Deniz Bakkalci, Alexander J. MacRobert, Umber Cheema   +3 more
wiley   +1 more source