Results 101 to 110 of about 7,758,263 (304)

Feedback regulation of Ran gene expression by Ran protein

, 2011
National Natural Science Foundation of China [30830084]; Hi-Tech Research and Development Program of China (863 program of China) [2010AA09Z403]; Ministry of Agriculture, China [201103034]; Chinese Universities Scientific FundRan, an abundant GTPase that
Wang, Jiajia, Zhang, Xiaobo, Zhao, Zhe, 赵哲   +3 more
core  

Investigating the Role of Gene-Gene Interactions in TB Susceptibility

PLOS ONE, 2015
Tuberculosis (TB) is the second leading cause of mortality from infectious disease worldwide. One of the factors involved in developing disease is the genetics of the host, yet the field of TB susceptibility genetics has not yielded the answers that were expected.
Daya, Michelle, Van der Merwe, Lize, Van Helden, Paul D., Moller, Marlo, Hoal, Eileen G.   +4 more
openaire   +5 more sources

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Gene2vec: distributed representation of genes based on co-expression

BMC Genomics, 2019
Background Existing functional description of genes are categorical, discrete, and mostly through manual process. In this work, we explore the idea of gene embedding, distributed representation of genes, in the spirit of word embedding.
Jingcheng Du, Peilin Jia, Yulin Dai, Cui Tao, Zhongming Zhao, Degui Zhi   +5 more
doaj   +1 more source

New strategies for identifying gene-gene interactions in hypertension

Annals of Medicine, 2002
Essential hypertension is a common disease that has a complex multifactorial etiology. For this reason, it is not surprising that studies of the effects of single genes on hypertension have often failed to replicate the original findings. We propose, as a working hypothesis, that the failure to replicate some single locus results is because the impact ...
Jason H, Moore, Scott M, Williams
openaire   +2 more sources

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Polymorphism in Genes Encoding HSP40 Family Proteins is Associated with Ischemic Stroke Risk and Brain Infarct Size: A Pilot Study

Journal of Integrative Neuroscience
Background: Heat shock proteins (HSPs) play a critical role in the molecular mechanisms of ischemic stroke (IS). A possible role for HSP40 family proteins in atherosclerosis progression has already been revealed; however, to date ...
Ksenia A. Kobzeva, Denis E. Gurtovoy, Alexey V. Polonikov, Vladimir M. Pokrovsky, Evgeny A. Patrakhanov, Olga Y. Bushueva   +5 more
doaj   +1 more source

A gene-centered C. elegans protein-DNA interaction network

, 2006
SummaryTranscription regulatory networks consist of physical and functional interactions between transcription factors (TFs) and their target genes. The systematic mapping of TF-target gene interactions has been pioneered in unicellular systems, using ...
Walhout, Albertha J.M., Mango, Susan E., Deplancke, Bart, Mukhopadhyay, Arnab, Reece-Hoyes, John S., Martinez, Natalia J., Doucette-Stamm, Lynn, Hope, Ian A., Grove, Christian A., Sequerra, Reynaldo, Ao, Wanyuan, Walhout, Albertha J. M., Elewa, Ahmed M., Tissenbaum, Heidi A., Hope, I. A., Martinez, Natalia Julia, Sequerra, R., Mango, S. E., Ao, W., Walhout, A. J., Walhout, Albertha J M, Grove, C. A., Deplancke, B., Tissenbaum, H. A., Doucette-Stamm, L., Elewa, A. M., Martinez, N. J., Mukhopadhyay, A., Reece-Hoyes, J. S.   +28 more
core   +1 more source