Results 111 to 120 of about 2,615,001 (338)
FEBS Letters, EarlyView.This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley +1 more source
Analyzing a co-occurrence gene-interaction network to identify disease-gene association
BMC Bioinformatics, 2019 Background Understanding the genetic networks and their role in chronic diseases (e.g., cancer) is one of the important objectives of biological researchers.
Amira Al-Aamri +4 more
doaj +1 more source
A Dynamic P53-MDM2 Model with Time Delay
, 2005 Specific activator and repressor transcription factors which bind to specific regulator DNA sequences, play an important role in gene activity control.
Adimy +10 more
core +1 more source
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
Investigating the Role of Gene-Gene Interactions in TB Susceptibility
PLOS ONE, 2015 Tuberculosis (TB) is the second leading cause of mortality from infectious disease worldwide. One of the factors involved in developing disease is the genetics of the host, yet the field of TB susceptibility genetics has not yielded the answers that were expected.
Daya, Michelle +4 more
openaire +5 more sources
roben: Robust Bayesian Variable Selection for Gene-Environment Interactions [PDF]
, 2020 Jie Ren, Fei Zhou, Xiaoxi Li, Cen Wu
openalex +1 more source
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
Gene2vec: distributed representation of genes based on co-expression
BMC Genomics, 2019 Background Existing functional description of genes are categorical, discrete, and mostly through manual process. In this work, we explore the idea of gene embedding, distributed representation of genes, in the spirit of word embedding.
Jingcheng Du +5 more
doaj +1 more source
The cultural epigenetics of psychopathology: The missing heritability of complex diseases found? [PDF]
, 2009 We extend a cognitive paradigm for gene expression based on the asymptotic limit theorems of information theory to the epigenetic epidemiology of mental disorders.
Wallace, Rodrick
core +1 more source