Results 181 to 190 of about 7,342,964 (293)

Gene-Gene Interaction Between Factor-<i>XI</i> and <i>ABO</i> Genes in Cerebral Venous Thrombosis: The BEAST Study. [PDF]

Neurology
Ken-Dror G, Martinelli I, Grandone E, Hiltunen S, Lindgren E, Margaglione M, Le Cam Duchez V, Triquenot AB, Zedde M, Mancuso M, Ruigrok YM, Worrall BB, Majersik JJ, Putaala J, Haapaniemi E, Zuurbier S, Brouwer MC, Passamonti SM, Abbattista M, Bucciarelli P, Lemmens R, Pappalardo E, Costa P, Colombi M, De Sousa DA, Rodrigues SG, Canhao P, Tkach A, Santacroce R, Favuzzi G, Arauz A, Colaizzo D, Spengos K, Hodge A, Ditta R, Pezzini A, Coutinho JM, Thijs VN, Jood K, Pare G, Tatlisumak T, Ferro JM, Sharma P.   +42 more
europepmc   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

[Telegrams to Jack Ruby from Frank and Andy and Gene Olson, November 24, 1963 #1]

, 1963
Individual telegrams by Frank and Andy and Gene Olson to Jack Ruby, congratulating him for killing Lee Harvey ...
Olson, Gene
core  

Genome-wide epistasis analysis reveals gene-gene interaction network on an intermediate endophenotype P-tau/Aβ₄₂ ratio in ADNI cohort. [PDF]

Sci Rep
Zhang Q, Liu J, Liu H, Ao L, Xi Y, Chen D.   +5 more
europepmc   +1 more source

Important gene-gene interaction of TNF-α and VDR on osteoporosis in community-dwelling elders. [PDF]

PLoS One, 2019
Liao LN, Li CI, Wu FY, Yang CW, Lin CH, Liu CS, Lin WY, Li TC, Lin CC.   +8 more
europepmc   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Letter to George, from Gene, Burnett, Wisconsin, May 18, 1862

An item in the George Woodard and Gene Smith letters ...
Woodard, George T., -1864, Smith, Gene E.   +1 more
core  

[Telegrams to Jack Ruby from Frank and Andy and Gene Olson, November 24, 1963 #2]

, 1963
Individual telegrams by Frank and Andy and Gene Olson to Jack Ruby, congratulating him for killing Lee Harvey ...
Olson, Gene
core  

Evaluation of gene-gene interaction between the interleukin (IL)-2 and IL-2RA gene polymorphisms in schizophrenia patients in the Turkish Population. [PDF]

Neurosciences (Riyadh)
Ozdilli K, Mervan Aytac H, Ceren Tuncel F, Oyaci Y, Pehlivan M, Pehlivan S.   +5 more
europepmc   +1 more source