Results 251 to 260 of about 7,342,964 (293)
, 1938 Some of the next articles are maybe not open access.
Related searches:
Related searches:
Analysis of Gene‐Gene Interactions
Current Protocols in Human Genetics, 2017AbstractThe goal of this unit is to introduce epistasis, or gene‐gene interactions, as a significant contributor to the genetic architecture of complex traits, including disease susceptibility. This unit begins with an historical overview of the concept of epistasis and the challenges inherent in the identification of potential gene‐gene interactions ...
Brian S, Cole +4 more
openaire +2 more sources
Assessing Gene-Gene Interactions in Pharmacogenomics
Molecular Diagnosis & Therapy, 2012In pharmacogenomics studies, gene-gene interactions play an important role in characterizing a trait that involves complex pharmacokinetic and pharmacodynamic mechanisms, particularly when each involved feature only demonstrates a minor effect. In addition to the candidate gene approach, genome-wide association studies (GWAS) are widely utilized to ...
Hsien-Yuan, Lane +2 more
openaire +2 more sources
Analysis of Gene‐Gene Interactions
Current Protocols in Human Genetics, 2003AbstractThe goal of this unit is to introduce gene‐gene interactions (epistasis) as a significant complicating factor in the search for disease susceptibility genes. This unit begins with an overview of gene‐gene interactions and why they are likely to be common.
openaire +3 more sources
2012
Chapter 8 discusses gene-gene interactions. The focus is on two-locus interactions. Different genetic models are incorporated in the two-locus models. The expressions of odds ratios for the main genetic effects and the gene-gene interaction are given. A saturated logistic regression model is also studied.
Gang Zheng +3 more
openaire +1 more source
Chapter 8 discusses gene-gene interactions. The focus is on two-locus interactions. Different genetic models are incorporated in the two-locus models. The expressions of odds ratios for the main genetic effects and the gene-gene interaction are given. A saturated logistic regression model is also studied.
Gang Zheng +3 more
openaire +1 more source
Pharmacogenomics, 2010
In this study we explored possible epistasis between CYP2D6 (*3, *4, *5, *6 and *1xN), CYP3A5 (*3), CYP1A2 (*1C and *1F) and ABCB1 (G2677T) in schizophrenia and related disorders.A total of 344 patients diagnosed with schizophrenia and related disorders, and 484 healthy controls participated in the present study.
Patricia, Gassó +7 more
openaire +2 more sources
In this study we explored possible epistasis between CYP2D6 (*3, *4, *5, *6 and *1xN), CYP3A5 (*3), CYP1A2 (*1C and *1F) and ABCB1 (G2677T) in schizophrenia and related disorders.A total of 344 patients diagnosed with schizophrenia and related disorders, and 484 healthy controls participated in the present study.
Patricia, Gassó +7 more
openaire +2 more sources
Gene-Gene, Gene-Environment & Multiple Interactions in Colorectal Cancer
Journal of Environmental Science and Health, Part C, 2006This review comprehensively evaluates the influence of gene-gene, gene-environment and multiple interactions on the risk of colorectal cancer (CRC). Methods of studying these interactions and their limitations have been discussed herein. There is a need to develop biomarkers of exposure and of risk that are sensitive, specific, present in the pathway ...
openaire +2 more sources
Gene-Gene Interaction and Epistasis
2011This chapter defines the differing meanings of the words gene-gene interaction and “epistasis”. Epistasis can be loosely defined as the interaction between two or more genes. The differences between biological and statistical epistasis are examined and the decomposition of genetic variance in any system into single-locus and epistatic components of ...
openaire +4 more sources
Testing for Gene-Gene Interaction with AMMI Models
Statistical Applications in Genetics and Molecular Biology, 2010Studies have shown that many common diseases are influenced by multiple genes and their interactions. There is currently a strong interest in testing for association between combinations of these genes and disease, in particular because genes that affect the risk of disease only in the presence of another genetic variant may not be detected in marginal
Amina, Barhdadi, Marie-Pierre, Dubé
openaire +2 more sources