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Testing for Gene-Gene Interaction with AMMI Models
Statistical Applications in Genetics and Molecular Biology, 2010Studies have shown that many common diseases are influenced by multiple genes and their interactions. There is currently a strong interest in testing for association between combinations of these genes and disease, in particular because genes that affect the risk of disease only in the presence of another genetic variant may not be detected in marginal
Amina, Barhdadi, Marie-Pierre, Dubé
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Role of gene–gene/gene–environment interaction in the etiology of eastern Indian ADHD probands
Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2011Associations between attention deficit hyperactivity disorder (ADHD) and genetic polymorphisms in the dopamine receptors, transporter and metabolizing enzymes have been reported in different ethnic groups. Gene variants may affect disease outcome by acting synergistically or antagonistically and thus their combined effect becomes an important aspect to
Manali, Das +8 more
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Detecting Gene‐Gene Interaction in Linkage Analysis
Current Protocols in Human Genetics, 2005AbstractLinkage analysis has been very successful in identifying genes for many Mendelian diseases, but has not enjoyed the same level of success for complex diseases. A major reason is that complex diseases are multifactorial, involving multiple genes and environmental factors.
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Gene-Gene and Gene-Environment Interactions
2018Identifying gene-gene and gene-environment interactions may help us to better describe the genetic architecture for complex traits. While advances have been made in identifying genetic variants associated with complex traits through more dense panels of genetic variants and larger sample sizes, genome-wide interaction analyses are still limited in ...
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Gene-gene interactions in myocardial infarction
The Lancet, 2006www.thelancet.com Vol 367 May 27, 2006 1729 Shirish Sheth (Jan 21, p 185) rightly decries the appalling fact that, as a result of abortion, “about 100 million girls are missing from the world—they are dead”, and properly emphasises that, since 1986, all members of the Federation of Obstetric and Gynaecological Societies of India have been “asked to ...
Gilles Pernod +2 more
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Gene-gene interaction in asthma
American Journal of Human Genetics, 2002Asthma is a common respiratory disease that is characterized by variable airways obstruction caused by acute and chronic bronchial inflammation; associated phenotypes include bronchial hyperresponsiveness (BHR), elevated total serum immunoglobulin E (IgE) levels, and skin tests positive to common allergens.
Howard, TD +5 more
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Extracting Gene-Gene Interactions Through Curve Fitting
IEEE Transactions on NanoBioscience, 2012This paper presents a simple and novel curve fitting approach for generating simple gene regulatory subnetworks from time series gene expression data. Microarray experiments simultaneously generate massive data sets and help immensely in the large-scale study of gene expression patterns.
Ranajit, Das +2 more
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Modeling Gene–Gene Interactions in Schizophrenia
2016Abstract It has been suggested that a substantial portion of the heritable genetic component of schizophrenia risk reflects gene–gene interactions (“epistasis”) rather than simply the cumulative effect of multiple independent genes. However, clinical studies of epistatic interactions require considerable statistical power and place prohibitive ...
E. Von Cheong, Colm M.P. O’Tuathaigh
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On the choice of degrees of freedom for testing gene–gene interactions
Statistics in Medicine, 2014In gene–gene interaction analysis using single nucleotide polymorphism (SNP) data, empty cells arise in the genotype contingency table more frequently than in single SNP association studies. Empty cells lead to unidentifiable regression coefficients in regression model fitting.
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Inference of Gene–Gene Interaction and Its Function
The complex functions of cells are achieved through the interactions of diverse molecules and genes, and the analysis of gene interactions is essential to understanding the circuit of biological systems. Computational biology, machine learning, and artificial intelligence are becoming increasingly crucial for extracting insight into complex gene ...openaire +2 more sources